Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors

Mollace, Vincenzo; Muscoli, Carolina; Masini, Emanuela; Cuzzocrea, Salvatore; Salvemini, Daniela

doi:10.1124/pr.57.2.1

Cited by 326 publications

(342 citation statements)

References 443 publications

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“…36 It also increases PGE2 biosynthesis through a cGMP-independent pathway in the stomach after damage. 37 Our result was consistent with that obtained by Boveris et al and Morsy et al 38,39 In addition, a study by Donmez et al revealed that both losartan and enalapril produced a significant increase in NO and glutathione levels after 9 weeks of treatment. 40 Losartan, as one of the selective ARBs, was proved effective in enhancement the generation of antioxidant activity.…”

Section: Discussionsupporting

confidence: 83%

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Ahmed

Abdelrahim

Abdel-Latif

2016

Int J Basic Clin Pharmacol

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Section: Discussionsupporting

confidence: 83%

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Ahmed

Abdelrahim

Abdel-Latif

2016

Int J Basic Clin Pharmacol

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“…Compelling data have been generated supporting the concept that NO signalling is tightly coupled to the COX2-prostaglandin pathway and vice versa [83,84]. In the central nervous system, nNOS-derived NO stimulates COX2 activity in vivo and in vitro.…”

Section: (A) Mechanisms Linking No With Cox2 Expressionmentioning

confidence: 93%

Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced byl-DOPA?

Bortolanza

Padovan-Neto

Cavalcanti-Kiwiatkoski

et al. 2015

Phil. Trans. R. Soc. B

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Inflammatory mechanisms are proposed to play a role in l -DOPA-induced dyskinesia. Cyclooxygenase-2 (COX2) contributes to inflammation pathways in the periphery and is constitutively expressed in the central nervous system. Considering that inhibition of nitric oxide (NO) formation attenuates l -DOPA-induced dyskinesia, this study aimed at investigating if a NO synthase (NOS) inhibitor would change COX2 brain expression in animals with l -DOPA-induced dyskinesia. To this aim, male Wistar rats received unilateral 6-hydroxydopamine microinjection into the medial forebrain bundle were treated daily with l -DOPA (21 days) combined with 7-nitroindazole or vehicle. All hemi-Parkinsonian rats receiving l -DOPA showed dyskinesia. They also presented increased neuronal COX2 immunoreactivity in the dopamine-depleted dorsal striatum that was directly correlated with dyskinesia severity. Striatal COX2 co-localized with choline-acetyltransferase, calbindin and DARPP-32 (dopamine-cAMP-regulated phosphoprotein-32), neuronal markers of GABAergic neurons. NOS inhibition prevented l -DOPA-induced dyskinesia and COX2 increased expression in the dorsal striatum. These results suggest that increased COX2 expression after l -DOPA long-term treatment in Parkinsonian-like rats could contribute to the development of dyskinesia.

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“…It was reported that NO concentration was increased 30 minutes after the initiation of xylazine-ketamine anaesthesia but it did not differ 60 minutes after the induction of anaesthesia (Alva et al 2006). It has been shown elsewhere that COX activation modulates L-arginine-NO pathway and COX inhibition decreases NOS activity in human platelets (Chen et al 1997) thus, COX enzymes are clearly important receptor targets for the action of NO (Mollace et al 2005). The present study revealed that NO concentration decreased during 0.5 and 1 h in group FM compared to that found in group C. Therefore, it is suggested that rapid COX inhibition by FM may result from decreasing NO concentrations.…”

Section: Discussionmentioning

confidence: 99%

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Yilmaz¹,

Korkmaz²,

Jaroszewski³

et al. 2014

Polish Journal of Veterinary Sciences

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The aim of this study was to compare the effect of flunixin meglumine (FM) and meloxicam (M) on postoperative and oxidative stress in ovariohysterectomized bitches. Twenty four bitches were divided into three groups (n=8 in each) and treated during premedication as follows: FM (2.2 mg/kg, iv, Fluvil, Vilsan, Turkey), M (0.2 mg/kg, sc, Maxicam, Sanovel, Turkey) or 0.9% saline (1 ml, iv, IE, Turkey) -control (C) group. The concentrations of serum cortisol, nitric oxide (NO), malondialdehyde (MDA), antioxidant potential (AOP) and glutation (GSH) were measured in blood samples collected during incision (0 h), closure of incision line (0.5 h) and 1, 2.5, 12 and 24 hours after incision. It was observed that cortisol level was higher at 0.5, 1 and 2.5 h in group C (p < 0.05), 0.5 h in group FM (p < 0.001), and 1 and 2.5 h in group M (p < 0.01), as compared to that determine at 0 h. Group C showed higher cortisol level during 0.5 h (p < 0.05) than that found in the other groups. Group FM displayed lower levels during 1 h (p < 0.01) and 2.5 h (p < 0.05) as compared to those observed in other groups. Concentrations of MDA, AOP and GSH between all the groups did not show any significant differences. MDA level was higher at 0.5 and 1 h in group M (p < 0.05) than that found in group C and it was the lowest at 2.5 h in group C (p < 0.05). AOP was higher at 2.5 h in group FM and M (p < 0.05) than that observed in group C, and at 12 and 24 h in group M than that found in group C and FM. GSH did not show any significant differences between the groups. NO level in group FM after 12 h was higher (p < 0.05) than that at 0.5, 1 and 24 h. Moreover, NO level was lower at 0.5 (p < 0.01), 1 (p < 0.05) and 24 h (p < 0.05) in group FM than that observed in group C and M. In conclusion, flunixin meglumine decreases cortisol and NO levels more efficiently than meloxicam. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine in bitches.

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Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors

Cited by 326 publications

References 443 publications

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced byl-DOPA?

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

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