Modulatory Effect of a Unani Formulation (Jawarish amla sada) on Cyclophosphamide-induced Toxicity in Tumour Bearing Mice

Ahmad, Firoz

doi:10.9734/bjmmr/2012/1228

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…The result of the pilot study on the dose of cyclophosphamide appropriate for the study is at variance with the 50 mg/Kg cyclophosphamide used in the study by Ahmad, Rashid, Bhatia et al (2012). All animals survived the experimental period.…”

Section: Discussionmentioning

confidence: 91%

Histopathological effects of Averon®, an indigenous herbal formulation, on Cyclophosphamide - induced immunosuppressed male rats

et al. 2015

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Introduction: The study investigated the effect of an acclaimed immunoboosting herbal formulation, Averon  , which contains Aloe spp on some basal physiological and pathophysiological profiles in immunomodulated male rats. Materials and Methods: Six groups of male rats were used for the study: control group received water and pelletized food ad libitum, Negative control Cyclophosphamide-treated group (30mg/kg i.p), two groups pre-treated with Cyclophosphamide (30mg/kg i.p) and followed by oral 200mg/kg and 400 mg/kg Averon  respectively, two groups orally pre-treated with 200mg/kg and 400 mg/kg Averon  respectively and followed by Cyclophosphamide (30mg/kg i.p) on the last three days. The experimental design was characterized by observations for behavioral changes in the rats, changes in body weight, food consumption, water intake and gross histopathological changes after sacrifice. Results: The results revealed the adverse effects in the cyclophosphamide pre-treated groups in the behavioral pattern, significant decrease in body weights at several p-values, significant decrease in food intake (p< 0.05), significant drop in water consumption and toxicological effects on the studied organs. The reverse was true for the Averon  -pretreated groups: significant increase in body weights, food intake and water consumption. The adverse effect of cyclophosphamide was most pronounced on the lungs with little or no amelioration of the adverse effects on the pulmonary milieu. However, there was remarkable recovery on the livers, kidneys and the hearts on treatment with Averon  , particularly at the higher doses. Conclusion: Averon  showed tissue ameliorating potential except on the lungs, hence the need for therapeutic monitoring when administered to immunosuppressed subjects.

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Section: Discussionmentioning

confidence: 91%

Histopathological effects of Averon®, an indigenous herbal formulation, on Cyclophosphamide - induced immunosuppressed male rats

et al. 2015

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“…Recently, immunomodulatory and anti-mycobacterial activities of JAS available in the market have been reported. [3,4] Literature survey revealed that the formulation composition of the marketed formulation varies significantly in terms of the number as well as the percent component of ingredients. In order to have uniform quality as well as batch to batch consistency, there is an urgent need to have some reference standards for quality control and standardization of this formulation.…”

Section: The Formulation Includes Six Medicinal Herbs Namelymentioning

confidence: 99%

Quality evaluation and standardization of a traditional Unani formulation Jawarish-e-Amla Sada

Shailajan¹,

Matani²,

Swar³

et al. 2015

Int J Green Pharm

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Background: Jawarish-e-Amla Sada (JAS) is a traditional Unani formulation commonly used for the clinical treatment of Zof-e-Meda (weakness of the stomach), Zof-e-Kabid (weakness of the liver), Zof-e-Qalb (weakness of the heart), Khafqan (palpitation), Nafkh-e-Shikam (flatulence in the stomach) and Is-Hal-e-Safrawi (biliary diarrhoea). It is a semisolid polyherbal preparation of six medicinal plants. Aims and Objectives: In the present research work an attempt has been made to establish the physicochemical, phytochemical and safety profile of JAS which may be useful for its quality control and standardization. Materials and Methods: Standardized operating procedure for the preparation of JAS was developed in accordance with National Formulary of Unani Medicine. The formulation was also subjected to preliminary phytochemical and physicochemical evaluation. Chemical characterization of the formulation was carried out on the basis of gallic acid content using a validated high-performance thin layer chromatographic method. Safety of the formulation was affirmed by conducting acute oral toxicity in mice. Results: Preliminary phytochemical, physicochemical and chromatographic profile of the formulation was established. The formulation was found safe up to an oral dose of 2 g/kg body weight in mice. Conclusion: Findings of the present work can be used as a reference standard by quality control/assurance laboratory of a pharmaceutical firm in order to have a proper quality check over its preparation and processing.

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“…It is easily available and cheap. Retrolective survey of ancient literature and scientific studies revealed that amla ( Emblica officinalis ) is an antipyretic, hepato-protective, appetizer, anti-tussive, nervine tonic, antihemorrhagic, anti-inflammatory drug7 which strengthens the vital organs and stomach and enhances vision. It is also a good blood purifier which inhibits production of morbid balgham and sauda.…”

Section: Selection Criteria For Adjuvant Drugmentioning

confidence: 99%

“…Jawarish amla as an adjuvant therapy may increase the efficiency of DOTS therapy, reduce the number of drug resistance cases and side effects as well as reverse the consequences and rejuvenate body power. A recent study of Jawarish amla “showed potential to provide protection against toxic effects of cyclophosphamide in tumour bearing mice.”7 Thus a study using Jawarish amla, an Unani adjuvant compound formulation, has been undertaken to evaluate its efficacy in combating the side effects of ATT drugs, reversing the adverse consequences of DOTS therapy, boosting general immunity and facilitating a complete recovery from TB.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Trial of Jawarish Amla as Adjuvant to Anti-Tubercular Treatment Drugs for Control of Adverse Reactions in DOTS Regime in Pulmonary TB Patients

Sherwani¹,

Zulkifle²,

Rehmatulla³

2013

J Islam Med Assoc

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Background and objectivesOne of the greatest challenges of health care systems at the dawn of the 21st century is tuberculosis (TB). Drug resistant strains of TB are becoming a global public health risk. These strains commonly appear due to faulty therapies. Patients frequently stop treatment due to the toxicity of anti-tubercular treatment (ATT) drugs. Amla (Emblica officinalis) is a well-known Unani single drug. Jawarish amla is a Unani compound formulation which is commonly used to administer amla. This study tested the efficacy of Jawarish amla as an adjuvant to ATT drugs in reducing their side effects.Methodology:Half of forty eligible pulmonary tuberculosis patients were randomly assigned to Test (Group B) and the other half to Control (Group A). Six grams of Jawarish amla twice daily was administered to the test group, and the same dosage of placebo was administered to control group along with directly observed treatment, short course chemotherapy (DOTS) for 60 days. Fisher exact test and paired t-test were applied for efficacy evaluation. Grading of symptoms was done to assess the toxicity of ATT and outcome of the adjuvant.Results and discussion:Significant improvements were observed in almost all subjective and objective parameters. The exceptions were serum creatine and serum uric acid, which showed non-significant slight elevations within normal limits.Conclusion:Jawarish amla was ascertained to be safe and effective adjuvant of DOTS in combating the adverse effects of ATT drugs.

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Modulatory Effect of a Unani Formulation (Jawarish amla sada) on Cyclophosphamide-induced Toxicity in Tumour Bearing Mice

Cited by 5 publications

References 40 publications

Histopathological effects of Averon®, an indigenous herbal formulation, on Cyclophosphamide - induced immunosuppressed male rats

Histopathological effects of Averon®, an indigenous herbal formulation, on Cyclophosphamide - induced immunosuppressed male rats

Quality evaluation and standardization of a traditional Unani formulation Jawarish-e-Amla Sada

A Pilot Trial of Jawarish Amla as Adjuvant to Anti-Tubercular Treatment Drugs for Control of Adverse Reactions in DOTS Regime in Pulmonary TB Patients

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