Moesin Is a Biomarker for the Assessment of Genotoxic Carcinogens in Mouse Lymphoma

Lee, Yoen Jung; Choi, In Kwon; Sheen, Yhun Yhong; Park, Sue Nie; Kwon, Ho Jeong

doi:10.1007/s10059-012-2271-8

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…The AMPs (0–40 μg/ml) were added to each well and the cells were incubated for up to 72 h. After 72 h, the cells were stained with Trypan blue and counted using a hemocytometer as described previously (Jung et al, 2003a; Lee et al, 2012a). …”

Section: Methodsmentioning

confidence: 99%

“…HUVECs were seeded at a density of 1.5 × 10 4 cells/well in gelatin-coated 24-well culture plates (SPL Life Sciences, Korea). The AMPs (0–40 μg/ml) were added to each well and the cells were incubated for up to 72 h. After 72 h, the cells were stained with Trypan blue and counted using a hemocytometer as described previously ( Jung et al, 2003a ; Lee et al, 2012a ).…”

Section: Methodsmentioning

confidence: 99%

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Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf

Jung¹,

Kim²,

Lee³

et al. 2015

Molecules and Cells

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The induction of angiogenesis is a crucial step in tumor progression, and therefore, efficient inhibition of angiogenesis is considered a powerful strategy for the treatment of cancer. In the present study, we report that the lipophilic antimicrobial peptides from EML-CAP3, a new endophytic bacterial strain isolated from red pepper leaf (Capsicum annuum L.), exhibit potent antiangiogenic activity both in vitro and in vivo. The newly obtained antimicrobial peptides effectively inhibited the proliferation of human umbilical vein endothelial cells at subtoxic doses. Furthermore, the peptides suppressed the in vitro characteristics of angiogenesis such as endothelial cell invasion and tube formation stimulated by vascular endothelial growth factor, as well as neovascularization of the chorioallantoic membrane of growing chick embryos in vivo without showing cytotoxicity. Notably, the angiostatic peptides blocked tumor cell-induced angiogenesis by suppressing the expression levels of hypoxia-inducible factor-1α and its target gene, vascular endothelial growth factor (VEGF). To our knowledge, our findings demonstrate for the first time that the antimicrobial peptides from EML-CAP3 possess antiangiogenic potential and may thus be used for the treatment of hypervascularized tumors.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf

Jung¹,

Kim²,

Lee³

et al. 2015

Molecules and Cells

Self Cite

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“…Van Den Wijngaard and others () proposed that microbes utilize the enzyme HHD to oxidize 3‐MCPD to glycidol but did not mention specifically which microbes utilized the aforementioned pathway (they stated that the microbes were Gram‐positive). Glycidol is a genotoxic carcinogen (Lee and others ) that has been classified as Group 2A (IARC ). Glycidol can be hydrolyzed to glycerol and, conversely, glycidol can be deconjugated and acetylated to form mercapturic acid (Lynch and others ).…”

Section: Metabolism Of 3‐mcpdmentioning

confidence: 99%

3‐Chloropropane‐1,2‐diol (3‐MCPD) in Soy Sauce: A Review on the Formation, Reduction, and Detection of This Potential Carcinogen

Lee

Khor

2014

Comp Rev Food Sci Food Safe

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Soy sauce, a dark-colored seasoning, is added to enhance the sensory properties of foods. Soy sauce can be consumed as a condiment or added during the preparation of food. There are 3 types of soy sauce: fermented, acid-hydrolyzed vegetable protein (acid-HVP), and mixtures of these. 3-Chloropropane-1,2-diol (3-MCPD) is a heatproduced contaminants formed during the preparation of soy sauce and was found to be a by-product of acid-HVPproduced soy sauce in 1978. 3-MCPD has been reported to be carcinogenic, nephrotoxic, and reproductively toxic in laboratory animal testing and has been registered as a chemosterilant for rodent control. 3-MCPD is classified as a possible carcinogenic compound, and the maximum tolerated limit in food has been established at both national and international levels. The purpose of this review is to provide an overview on the detection of 3-MCPD in soy sauce, its toxic effects, and the potential methods to reduce its concentration, especially during the production of acid-HVP soy sauce. The methods of quantification are also critically reviewed with a focus on efficiency, suitability, and challenges encountered in analysis.

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“…Prof. Midori Arai of Chiba University talked about the characteristics of flavonoid molecule libraries and how they are being used to study molecules that affect DNA-binding proteins . Prof. Ho Jeong Kwon of Yonsei University in Korea presented the discovery of small molecules targeting angiogenesis and their target proteins identification using phage display biopanning . Prof. Kyeong Lee of Dongguk University explained small molecules that target MDR1 and HIF-1α discovered in focused libraries .…”

Section: Scientific Meeting Overviewmentioning

confidence: 99%

Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting

Morii

Uesugi

2012

ACS Chem. Biol.

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Moesin Is a Biomarker for the Assessment of Genotoxic Carcinogens in Mouse Lymphoma

Cited by 3 publications

References 32 publications

Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf

Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf

3‐Chloropropane‐1,2‐diol (3‐MCPD) in Soy Sauce: A Review on the Formation, Reduction, and Detection of This Potential Carcinogen

Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting

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