MOF materials as therapeutic agents, drug carriers, imaging agents and biosensors in cancer biomedicine: Recent advances and perspectives

Highly efficient fluorescent chemosensor for nitro antibiotic detection based on luminescent coordination polymers with 2,6-di(4-carboxyphenyl)pyrazine

“…The emergence of porous coordination polymers (PCPs) with unprecedented diversity in structures and functions has become a significant materials chemistry achievement over the past two decades. Crystalline materials' porosity and tailored functionality have attracted extensive attention in application areas of gas storage, [1][2][3] separation, [4][5][6] luminescence, [7][8][9] piezoelectricity, [10][11][12] catalysis, [13][14][15] magnetism, [16][17][18] biomedicine, [19][20][21] sensors, [22][23][24] and so on. Considering their large specific surface area, adjustable pore size, and surface chemical sites, compared to all the applications, exploring the potential use of PCPs as chemical sensors has broad application prospects and extraordinary significance.…”

Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

“…Typically, surface adsorption, pore encapsulation, covalent binding, and the use of the functional molecules as the building blocks are the possible approaches for the functionalization of MOFs. Functional molecules can be easily adsorbed on the MOF surface, given their highly porous structure [24,25]. This phenomenon is supported by the hydrogen bonding, van der Waals interactions, and π-π interactions, as applied in enzyme immobilization.…”

Research development in tumor therapy: role of iron-related nanoparticles

“…This therapy takes advantage of the weak acid microenvironment of the tumor as the reaction conditions, overexpressed H2O2 as reaction raw materials, and transition metal nanomaterials as a catalyst, by triggering Fenton reaction, catalyzing H 2 O 2 to produce hydroxyl radicals (•OH) and other kinds of ROS, oxidizing tumor cell membrane, protein, and DNA molecules, eventually inducing tumor cell apoptosis [72]. Through the endogenous biochemical cascade induced by TME, CDT can solve the deep penetration problem without phototoxicity and has the inherent TME-specific targeting property [67], thus becoming an innovative anticancer strategy.…”