Molecular Analysis of Blood with Micro‐/Nanoscale Field‐Effect‐Transistor Biosensors

Abstract

Rapid and accurate molecular blood analysis is essential for disease diagnosis and management. Field Effect Transistor (FET) biosensors are a type of device that promise to advance blood point-of-care testing by offering desirable characteristics such as portability, high sensitivity, brief detection time, low manufacturing cost, multiplexing, and label-free detection. By controlling device parameters, desired FET biosensor performance is obtained. This review focuses on the effects of sensing environment, micro/nanoscale device structure, operation mode, and surface functionalization on device performance and long-term stability.

Highly stable organic polymer field-effect transistor sensor for selective detection in the marine environment

“…S3) 27,35 . The average electrical figures of merit were calculated over four different devices (threshold voltage (V th )B À 1.62±1.25 V, mobility (m) B0.035±0.02 cm 2 Vs À 1 and on/off ratio 4130, Supplementary Table S1 and Supplementary Note 1). To study the organic semiconductor/ liquid environment interface, we also performed liquid-gating measurements 36 of our OFET devices by using a reference electrode to apply a potential to the liquid (V lg ) (inset Fig.…”

“…T he use of field-effect transistors (FETs) for portable, labelfree sensing applications in the field of healthcare and environmental monitoring has received great attention in recent decades [1][2][3][4] . Such devices allow for the transduction and conversion of a (bio-)chemical interaction into an electrical signal, providing compatibility with digital read-out methods.…”

Effect of temperature on the synthesis of nanoporous carbon from copper/carbon thin films to nanoporous carbon for sensing applications

“…Since many years, MOSFET sensors have been studied for applications of detection (pH, DNA, protein...) [31][32][33][34]. The goal of this part is to demonstrate that the relatively low temperature process that we have developed in this study to synthesize np-C thin films is fully compatible with the integration of such a functional material on the active surface of a Metal…”

Electroanalytical Sensor Technology

“…This is in a large way due to the concurrent advances in nanotechnology which has allowed the fabrication of novel sensors possessing signal transduction mechanisms that exploit the unique physical phenomena of the nanoscale [81]. These sensors may utilise, for example, the spectroscopy of plasmonic nanoparticles, the deflection of cantilevers and the conductivity of nanowires [81,82].…”