Molecular analysis of foot-and-mouth disease type O viruses 

isolated in Saudi Arabia between 1983 and 1995

Samuel, A. R.; Knowles, Nick J.; Kitching, R.; Hafez, S. M.

doi:10.1017/s0950268897008285

Cited by 38 publications

(22 citation statements)

References 14 publications

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“…Among the different attempts to improve the immunogenicity of these peptides, its expression as part of the hepatitis B core structure was the most promising [54]. In 1986, DiMarchi et al [70] reported protection to viral challenge in cattle immunised with a peptide in which the amino acids of the G-H loop were co-linearly synthesised with those corresponding to the carboxy terminus of VP1 (residues [200][201][202][203][204][205][206][207][208][209][210][211][212][213]. The induction of significant levels of heterologus protection in the guinea-pig with this tandem peptide has also been reported [73].…”

Section: Peptide Vaccinesmentioning

confidence: 99%

“…3) and it allows derivation of informative phylogenetic comparisons [145]. Its analysis has provided a considerable amount of information for type O, A, C, Asia, SAT 1 and SAT 2 serotypes [63,144,173,210,211,246]. The OIE/FAO World Reference Laboratory for foot-and-mouth disease, at Pirbright, UK edits a web page in which an FMDV sequence data base is available (http://www.iah.bbsrc.ac.uk/virus/ Picornaviridae/aphthovirus/fmdv.htm).…”

Section: Diagnosis and Viral Characterisationmentioning

confidence: 99%

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Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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-Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV has become a model system in animal virology and a considerable amount of information on its structure, biology and vaccinology has been obtained. However, the disease that this virus produces (FMD) still constitutes one of the main animal health concerns. In this review, we have attempted to summarise the state of the knowledge in different basic and applied areas of FMDV research, with emphasis on those aspects relevant to the control of the disease. FMDV / structure / immunity / vaccine / variability / diagnosisRésumé -Le virus de la fièvre aphteuse : un virus connu de longue date, qui demeure une menace. Le virus de la fièvre aphteuse a été le premier virus animal identifié. Depuis lors, il est devenu un système modèle en virologie animale, et une quantité importante d'informations sur sa structure, sa biologie et sa vaccinologie a été obtenue. Cependant la maladie provoquée par ce virus constitue encore une inquiétude majeure en santé animale. Dans cette revue, nous avons tenté de résumer l'état des connaissances dans différents domaines de recherche, à la fois fondamentaux et appliqués, sur le virus de la fièvre aphteuse, en mettant l'accent sur les aspects relatifs au contrôle de la maladie. virus de la fièvre aphteuse / immunité / vaccin / variabilité / diagnostic

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Section: Peptide Vaccinesmentioning

confidence: 99%

Section: Diagnosis and Viral Characterisationmentioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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“…We used nucleotide sequences acquired directly from specimens to circumvent any genetic changes associated with cell culture or animal adaptation [6]. It is generally accepted that FMD viruses are closely related to each other if the sequence variations of the 3' end of the 1D gene are less than 5% [12,16]. A nucleotide sequence divergence of the 3' end of the 1D gene was 0 to 3.8% among 7 Korean strains of the FMD virus, determined by the MegAlign program.…”

Section: Surveillance Of Fmdmentioning

confidence: 99%

“…In order to improve epidemiological trace of infectious agents, comparison of nucleotide sequences within a limited region of the genome has been used. In studies on FMDV molecular epidemiology, nucleotide sequencing of the partial 3' end of the 1D (VP1) gene and phylogenetic analysis have widely been utilized [5,12,13,16,18,21]. The aim of the study was to determine the genetic relatedness of Korean field strains of FMD virus obtained from 7 farms in 5 geographical locations prevailed during the spring 2000.…”

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confidence: 99%

Molecular Epidemiological Investigation of Foot-and-Mouth Disease Virus in Korea in 2000.

et al. 2003

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ABSTRACT. The genetic relatedness of 7 Korean type O field strains of foot-and-mouth disease virus (FMDV) in clinical specimens collected from 5 different geographic locations in 2000 was investigated. The sequence of 162 nucleotides (nt 478-639) at the 3' end of the 1D (VP1) genes was determined from amplified cDNA fragments, and subjected to the analysis for the sequence identity/diverge nce and phylogenetic relationship. The overall nucleotide sequence divergence among the 7 field strains was 0 to 3.8%, suggesting t hat they are closely related to each other. Phylogenetic analysis with the known Middle East-South Asia (ME-SA) topotype strains showed that the 7 Korean field strains formed two distinct clusters within the same lineage of the ME-SA topotype strains. Cluster 1 consisted of the strains of the primary foci of infection (Paju and Hongseong), and closely related to the strains prevailed in the Far East. Cluster 2 comprised those of subsequently affected regions (Boryeong, Yongin, and Chungju), and was further diverged from the Cluster 1. The result of phylogenetic analysis indicated that the Korean strains may have evolved from a common ancestor of the Pan Asia strains, and that at least 2 phylogenetically clustered variants within the same lineage were prevalent during the epidemic. The potential origin and sources of the virus introduction to Korea were discussed. KEY WORDS: foot and mouth disease, molecular epidemiology, serotype O.

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“…In addition, and for practical reasons, sequencing of the 200-250 nt from the 3' end of the VP1 gene -either from viral RNA or, more recently, from RT-PCR amplified cDNAs -has become a complement to the serology in the characterisation of field isolates. In this way, a significant amount of information is available for type O, A, C, Asia and SAT 1 and 2 serotypes [6,21,27,34,35]. However, a detailed analysis of the informative content of this region in viruses of different serotypes, with respect to the whole VP1 gene, has not been performed.…”

Section: Introductionmentioning

confidence: 99%

Identification of optimal regions for phylogenetic studies on VP1 gene of foot-and-mouth disease virus: analysis of types A and O Argentinean viruses

Núñez

Martı́n

Piccone³

et al. 2001

Vet. Res.

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-An analysis of the informative content of sequence stretches on the foot-and-mouth disease virus (FMDV) VP1 gene was applied to two important viral serotypes: A and O. Several sequence regions were identified to allow the reconstruction of phylogenetic trees equivalent to those derived from the whole VP1 gene. The optimal informative regions for sequence windows of 150 to 250 nt were predicted between positions 250 and 550 of the gene. The sequences spanning the 250 nt of the 3' end (positions 400 to 650), extensively used for FMDV phylogenetic analyses, showed a lower informative content. In spite of this, the use of sequences from this region allowed the derivation of phylogenetic trees for type A and type O FMDVs which showed topologies similar to those previously reported for the whole VP1 gene. When the sequences determined for viruses isolated in Argentina, between 1990 and 1993, were included in these analyses, the results obtained revealed features of the circulation of type A and type O viruses in the field, in the months that preceded the eradication of the disease in this country. Type A viruses were closely related to an Argentinean vaccine strain, and defined an independent cluster within this serotype. Among the type O viruses analysed, two groups were distinguished; one was closely related to the South American vaccine strains, while the other was grouped with viruses of the O3 subtype. In addition, a detailed phylogeny for type A FMDV is presented.foot-and-mouth disease virus / phylogenetic analysis / informative region / molecular epidemiology Vet. Res. 32 (2001) [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] 31

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Molecular analysis of foot-and-mouth disease type O viruses isolated in Saudi Arabia between 1983 and 1995

Cited by 38 publications

References 14 publications

Foot-and-mouth disease virus: a long known virus, but a current threat

Foot-and-mouth disease virus: a long known virus, but a current threat

Molecular Epidemiological Investigation of Foot-and-Mouth Disease Virus in Korea in 2000.

Identification of optimal regions for phylogenetic studies on VP1 gene of foot-and-mouth disease virus: analysis of types A and O Argentinean viruses

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