2010
DOI: 10.1002/ar.21196
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Molecular and Cellular Mechanisms of Ectodomain Shedding

Abstract: Left Panel: Lung tissue from a mouse 28 days post‐treatment with bleomycin. The tissue section, which was stained with Gomori's Trichrome stain shows increased collagen (blue) in the lung parenchyma. Right Panel: In situ binding assay showing the binding of rhCXCL8 to alveolar macrophages, alveolar septa, and the cell surface of airway epithelial cells. In this confocal image, rhCXCL8 is stained red, nuclei are stained with ToPro‐3 (Blue), and tissue autofluorescence (green) provides structural details. See Ha… Show more

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Cited by 45 publications
(66 citation statements)
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“…The extracellular domains of a number of transmembrane proteins are released from the cell surface as soluble proteins through a regulated proteolytic mechanism called ectodomain shedding (46,47). Only about 2% of cell surface proteins are released from the surface by ectodomain shedding, indicating that cells selectively shed their protein ectodomains (46).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The extracellular domains of a number of transmembrane proteins are released from the cell surface as soluble proteins through a regulated proteolytic mechanism called ectodomain shedding (46,47). Only about 2% of cell surface proteins are released from the surface by ectodomain shedding, indicating that cells selectively shed their protein ectodomains (46).…”
Section: Discussionmentioning
confidence: 99%
“…Only about 2% of cell surface proteins are released from the surface by ectodomain shedding, indicating that cells selectively shed their protein ectodomains (46). Cleavage often occurs in a juxtamembrane stalk region adjacent to the membrane anchor (47)(48)(49) and may require an unstructured or extended stalk of minimal length (50).…”
Section: Discussionmentioning
confidence: 99%
“…1A). By ectodomain shedding, they can also regulate the activity of certain growth factors and cytokines such as HB-EGF and TNF-, and membrane-spanning receptors such as c-Met (89)(90)(91).…”
Section: Expression Of Direct-acting Sasp Components Alonementioning
confidence: 99%
“…The protein a disintegrin and metalloproteinase domain 10 (ADAM10) is a cell surface sheddase that is able to cleave the extracellular domains of membrane-bound proteins and release the soluble ectodomain in a process known as 'ectodomain shedding' (Hayashida et al, 2010;Reiss and Saftig, 2009;Weber and Saftig, 2012). ADAM10 is crucial for the regulation of various physiological processes such as cell proliferation, differentiation and death (Gibb et al, 2011;Glomski et al, 2011;Guo et al, 2015;Jorissen et al, 2010;Tsai et al, 2014;Weber et al, 2011;Zhang et al, 2010).…”
Section: Introductionmentioning
confidence: 99%