Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

Solé-Magdalena, Antonio; Martínez-Alonso, Maira; Coronado, César; Junquera, Luís; Cobo, Juan; Vega, J.A.

doi:10.1016/j.aanat.2017.09.006

Cited by 42 publications

(45 citation statements)

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“…Many molecular candidates have been proposed as mediators of this problem . Tooth hypersensitivity after whitening treatments probably occurs as a consequence of the functional properties of the chemosensitive ion channel called TRPA1 (transient receptor potential channel with ankyrin domain‐type 1) . This ion channel is associated with the pain caused by oxidants, including hydrogen peroxide .…”

Section: New Approaches To Prevent Side Effectsmentioning

confidence: 99%

“…121 Tooth hypersensitivity after whitening treatments probably occurs as a consequence of the functional properties of the chemosensitive ion channel called TRPA1 (transient receptor potential channel with ankyrin domain-type 1). 122 This ion channel is associated with the pain caused by oxidants, including hydrogen peroxide. 123 Since the afferent fibers of primary dental pulp contain TRPA1, it is possible that direct TRPA1 activation of nerve fibers is involved in the pain caused by tooth whitening.…”

Section: New Approaches To Prevent Side Effectsmentioning

confidence: 99%

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Tooth whitening: From the established treatments to novel approaches to prevent side effects

Rodríguez-Martínez

Valiente

Sánchez-Martín

2019

J Esthet Restor Dent

134

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Objective The aim is to review the most important aspects about tooth whitening treatments, their side effects, and the new emerging approaches to overcome them. Overview This review is focused on origin of tooth stains, the whitening systems and their chemistry, their side effects, and the new approaches. The search of bibliography of the period 1965‐2018 has been analyzed. Conclusions Tooth whitening has become one of the most requested dental treatments by the public. Tooth stains are classified according to their origin into two categories: intrinsic and extrinsic. The whitening systems are generally organized into two classes: in‐office and at‐home products. Most of the whitening systems use hydrogen peroxide as the active oxidative agent to degrade the organic compounds that cause stains. The concentration ranges depending on the treatment, and it may be applied directly or produced in a chemical reaction from carbamide peroxide that is more stable. Besides its popularity, tooth whitening still has some side effects being tooth hypersensitivity the most common. In order to decrease these side effects, new treatments are constantly in renewal processes. Clinical Significance Despite all the data and new strategies known about tooth whitening, there are many aspects that are not totally fully understood and methodologies that are not completely effective. Therefore, the development of effective, efficient, and long‐lasting whitening treatments is still necessary.

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Section: New Approaches To Prevent Side Effectsmentioning

confidence: 99%

Section: New Approaches To Prevent Side Effectsmentioning

confidence: 99%

Tooth whitening: From the established treatments to novel approaches to prevent side effects

Rodríguez-Martínez

Valiente

Sánchez-Martín

2019

J Esthet Restor Dent

134

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“…Dentin sensitivity is a shared symptom of many tooth diseases, such as tooth decay, abrasion, and wedge‐shaped defects. Functional TRP channels in human odontoblasts play a crucial role in the transduction of tooth pain during the detection of mechanical, osmotic, pH‐related, and thermal stimuli, which activate secondary dentin formation (Kimura et al, ; Sole‐Magdalena et al, ). Recent research has indicated that glutamate can mediate intercellular communication among odontoblasts and trigeminal ganglion neurons via glutamate receptors in odontoblasts (Nishiyama et al, ).…”

Section: Clinical Significance: Ca2+ Signaling As a Therapeutic Targementioning

confidence: 99%

The emerging role of extracellular Ca²⁺ in osteo/odontogenic differentiation and the involvement of intracellular Ca²⁺ signaling: From osteoblastic cells to dental pulp cells and odontoblasts

2018

Journal Cellular Physiology

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Calcium ions (Ca ) is the main element of dental pulp capping materials. Ca signaling plays a crucial role in a myriad of cell activities. An overwhelming array of studies have already reported the experimental and clinical benefits of Ca -enriched materials in the treatment of teeth with accidental vital pulp exposure and incomplete root formation. Thus, Ca signaling has always been an excellent target for the design of various novel biomaterials for use in revitalizing or regenerative endodontic procedures. However, the molecular mechanisms that enable dental pulp cells (DPCs) to detect and respond to extracellular Ca have not been characterized in detail before. In this review, we mainly outline the pathways by which the cell detects and responds to extracellular Ca , as well as the relevant regulatory paths in DPCs and odontoblasts, and discuss the potential role of Ca as a therapeutic tool. Moreover, because DPCs share many of the same functional properties that are found in osteoblasts, some comparisons with bone cells were additionally incorporated into this text.

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“…The theories are not mutually exclusive and cannot be considered separately because of the presence of nerves and odontoblast processes within the dentinal tubules, bathing in the dentinal fluid, and the close apposition of the odontoblasts to the dentinal or basal nerves terminals (fig. 1) [8,9].…”

mentioning

confidence: 99%

“…1. Schematic representation of the three main theories explaining the dentin sensitivity [8] application of chemical and mechanical methods in dentin desensitization [15][16][17], before taking impressions. Gluma Desensitizer (Heraeus Kulzer, Germany), a dentinal bonding agent with the specific purpose to treat DS [18], contain 35% hydroxyethyl methacrylate (HEMA) and 5% glutaraldehyde in purified water.…”

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confidence: 99%

Comparative Desensitization Effect of Vital Abutments Realized by Different Methods

Biriș¹,

Bechir²,

Odor³

et al. 2019

Rev. Chim.

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Vital abutments presents different degree of dentinal sensitivity (DS) after their preparation. Protective methods of dentinal wound have the purpose to fill up the dentinal tubules. The objective of the study was to assess the efficacy of three different desensitization methods applied to reduce the postoperative sensitivity of prepared vital abutments. The clinical trial included 65 patients with 251 vital abutments, divided into three groups: in the first group of 21 patients (82 vital abutments) the protection method was carried out by a desensitizer agent containing hydroxyethyl methacrylate and glutaraldehyde; in the second group of 22 patients (85 vital abutments), diode laser therapy was used; in the third group of 22 patients (84 vital abutments), associated protection method was applied, by using the same desensitizer agent and laser therapy. During the study, all selected patients used the same toothpaste for at-home desensitization, containing 5% calcium sodium phosphosilicate (CSPS). The evaluation of the painful intensity of DS in vital abutments after desensitization was realized by using a Visual Analogue Scales (VAS) and by evaluating the failure rate. The results of study showed that after desensitisation, the DS of vital abutments has decreased in all three groups, but the highest desensitization rate with the most reduced rate of failures was found in the third group of patients, with associated therapies. The efficiency of the applied desensitization methods have been confirmed.

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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

Cited by 42 publications

References 152 publications

Tooth whitening: From the established treatments to novel approaches to prevent side effects

Tooth whitening: From the established treatments to novel approaches to prevent side effects

The emerging role of extracellular Ca²⁺ in osteo/odontogenic differentiation and the involvement of intracellular Ca²⁺ signaling: From osteoblastic cells to dental pulp cells and odontoblasts

Comparative Desensitization Effect of Vital Abutments Realized by Different Methods

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Molecular basis of dental sensitivity: The odontoblasts are multisensory cells and express multifunctional ion channels

Cited by 42 publications

References 152 publications

Tooth whitening: From the established treatments to novel approaches to prevent side effects

Tooth whitening: From the established treatments to novel approaches to prevent side effects

The emerging role of extracellular Ca2+ in osteo/odontogenic differentiation and the involvement of intracellular Ca2+ signaling: From osteoblastic cells to dental pulp cells and odontoblasts

Comparative Desensitization Effect of Vital Abutments Realized by Different Methods

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The emerging role of extracellular Ca²⁺ in osteo/odontogenic differentiation and the involvement of intracellular Ca²⁺ signaling: From osteoblastic cells to dental pulp cells and odontoblasts