Molecular biomarkers in diagnosis of bladder cancer

Ширяев, А. А.; Говоров, А. В.; Васильев, А. О.; Окишев, А. В.; Ким, Ю А; Федина, М С; Быков, П. И.; Пушкарь, Д. Ю.

doi:10.17650/1726-9776-2020-16-1-100-105

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…However, in 20-30% of cases, the treatment outcomes do not coincide with the expected ones. It became obvious that the establishment of one or several markers does not provide the necessary basis for predicting the disease course and, accordingly, making a decision on further treatment of the patient (Shiryaev et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Current issues of molecular diagnostics of bladder cancer

Nurman

Karim

Akhnazarov

et al. 2021

ijhs

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Nowadays, it is generally accepted that cancer is a genetic disease. Tumour cells appear due to the accumulation of mutations in critical proto-oncogenes and tumour suppressor genes. Urothelial bladder cancer is a frequent oncological pathology, and therefore it is a significant social problem. The practical relevance of the study is due to the fact that the findings can significantly improve the efficiency of bladder cancer diagnosis. The purpose of the study was to consider all modern methods for diagnosing bladder cancer in one paper. As a research method, the analysis of scientific data obtained from the experimental study of bladder cancer was carried out. According to the data of the investigated sources, a fairly large number of scientists believe that bladder cancer (BC) is one of the most common tumours affecting the urinary tract. It is believed that important prognostic factors include the presence of vascular invasion and tumour complexes in the vessels, which increases the risk of the secondary neoplasm growth even at the pT1 stage. However, when assessing vascular invasion, pathologists often mistake the cracks formed around the tumour complexes for vessels. In this case, the study suggests conducting an immunohistochemical analysis for clear visualisation of blood vessels.

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Section: Resultsmentioning

confidence: 99%

Current issues of molecular diagnostics of bladder cancer

Nurman

Karim

Akhnazarov

et al. 2021

ijhs

View full text Add to dashboard Cite

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VI-RADS system and levels of tumor microenvironment biomarkers in patients with muscle-invasive bladder cancer when choosing treatment tactics

et al. 2020

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Objective: to identify the role simultaneous use of the Vesical Imaging-Reporting and Data System (VI-RADS) and the assessment of serum levels of several mediators and growth factors for the evaluation of metastatic process and disease stage in patients with bladder cancer.Materials and methods. This retrospective study included 85 patients with histologically verified transitional cell (urothelial) bladder carcinoma (stages рТа—TINOMO. [)T2NOMO, рТ3—4NN0M0, and [)T2—4N1—3M1) and 20 healthy controls. In addition to general clinical examinations, all patients have undergone preoperative diffusion-weighted magnetic resonance imaging of the pelvis with background suppression. We calculated the diffusion coefficient and included it into the VI-RADS protocol. All study participants were also tested for their serum levels of vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), monocyte chemoattractant protein 1 (MSP-1), interferon γ (IFN-γ), transforming growth factor β1 (TGF- β1), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colonystimulating factor (GM-CSF) using enzyme-linked immunosorbent assay (ELISA).Results and conclusion. We found that the preoperative use of VI-RADS together with the assessment of serum levels of pro-inflammatory mediators, colony-stimulating factors, and growth factors in patients with muscle-invasive bladder cancer provide additional information about the activity of malignant transformation in tumor tissue and tumor spread. Their simultaneous use during the examination of patients with muscle-invasive bladder cancer is a promising diagnostic approach to monitor treatment response.

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Markers of bladder cancer: their role and prognostic significance (literature review)

et al. 2021

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This review article is devoted to the main problems of early diagnostic and prognosis of non-muscle-invasive bladder cancer, which accounts for 75 % of all newly detected cases of bladder cancer according to statistics. Chromosomal disorders that have been detected in urothelial cells can lead to the development of non-muscle-invasive bladder cancer. The review highlights the main problems of existing diagnostic systems for bladder cancer, their disadvantage and limitations of use in practice. Special attention is given to tumor stem cells, which are actively involved in the development of relapses of malignant neoplasms, and, also play an important role in the development of chemo - and radioresistance of tumor cells. Their significance in the diagnosis, detection of disease recurrence and the possibility of using the data obtained to adjustment therapeutic methods of treatment in oncology is one of the main tasks in cancer pathology.

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Molecular biomarkers in diagnosis of bladder cancer

Cited by 4 publications

References 22 publications

Current issues of molecular diagnostics of bladder cancer

Current issues of molecular diagnostics of bladder cancer

VI-RADS system and levels of tumor microenvironment biomarkers in patients with muscle-invasive bladder cancer when choosing treatment tactics

Markers of bladder cancer: their role and prognostic significance (literature review)

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