Molecular cloning of the fish interferon stimulated gene, 15 kDa (ISG15) orthologue: a ubiquitin-like gene induced by nephrotoxic damage

Gene structures and promoter characteristics of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-7 from snakehead Channa argus

“…In teleosts, IFN molecules have been cloned and characterized from zebrafish (Danio rerio), pufferfish (Tetraodon nigroviridis), atlantic salmon (Salmo salar) and channel catfish (Ictalurus punctatus) since 2003 (Altmann et al, 2003;Robertsen et al, 2003;Long et al, 2004;Igawa et al, 2006). ISGs and their promoters were identified in rainbow trout (Oncorhynchus mykiss) Mx1 and Vig-2, Goldfish (Carassius auratus) and Atlantic cod (Gadus morhua) ISG15 (Collet and Secombes, 2001;Boudinot et al, 2001;Liu et al, 2002;Seppola et al, 2007). Among teleost IRFs, IRF-1 has been cloned and characterized from flounder (Paralichthys olicaceus), pufferfish (Fugu rubripes), rainbow trout (Oncorhynchus mykiss), turbot (Scophthamus maximus) and sea bream (Sparus aurata) (Yabu et al, 1998;Richardson et al, 2001;Collet et al, 2003a,b;Ordas et al, 2006).…”

Effects of systemic versus local gentamicin on the inner ear in the Atlantic cod, Gadus morhua (L.), relevance for fish hearing investigations

“…After intramuscular injections of gentamicin, health disorders were common in the fish: loss of appetite, erratic swimming behaviour associated with weight gain, bloating of the abdomen and swelling around the eyes, indicative of osmoregulatory problems (Yan et al, 1991;Lombarte et al, 1993). Gentamicin causes renal injury after peritoneal injection in the goldfish, C. auratus (Liu et al, 2002). Nephrotoxicity and ototoxicity following aminoglycoside antibiotic treatment are well known in mammals (Dulon et al, 1988;Forge and Schacht, 2000).…”

Molecular characterization and IFN signal pathway analysis of Carassius auratus CaSTAT1 identified from the cultured cells in response to virus infection

“…From the same cell system CaIRF7 was also cloned and could be activated by CAB IFN [27], hinting that fish IRF7 may function as mammalian IRF7 to participate in the IFN signaling cascade. Recently, like most of mammalian ISGs, the characteristic sequence designated ISRE, the binding site for the formation of ISGF3 complex in the context of JAK -STAT signal transmission, was also verified to position in the promoters of some fish ISGs, including pufferfish Mx [32], ISG15 [33], rainbow trout Mx1 [57] and Vig-2 gene [35]. These results above, combined with the previous observation that zebrafish STAT1 can rescue interferon-signaling functions in a STAT1-deficient human cell line [14], provide supporting evidence for the conclusion that fish IFN signaling transduction pathway and antiviral mechanism are similar to that in mammals, that is a JAK -STAT signal pathway.…”

“…IFN activity materials have been reported to exist in different fish species and fish cultured cells and several IFN-responsive genes, such as IRF [27 -30], Mx [31,32], ISG15 [33], vig-1 [34], and Vig-2 [35], have been cloned from various fish species, respectively. The members of Janus kinase family, such as JAK1 and Tyk2, were also identified in fish [36,37].…”