Molecular Epidemiological Evaluation of the Recent Resurgence in Mumps Virus Infections in Ireland

Abstract

We observed a strong bias for acute mumps virus infection in males compared to females (P < 10 ؊32 ) that was independent of vaccination status.

Virological Analysis of a Regional Mumps Outbreak in the Northern Island of Japan&mdash;Mumps Virus Genotyping and Clinical Description

“…None of the samples from the 3 vaccinated patients were successfully analyzed due to amplification failure. Nonetheless, our success rate was comparable with that of previous reports (9,10).…”

“…Mumps outbreaks, even among vaccinated populations, have recently been reported worldwide, including in the UK, the US, the Netherlands, and Canada (10)(11)(12)(13)(14). In the present outbreak, we detected MuV genotype G, which has been the predominant genotype commonly detected in recent outbreaks.…”

Factors influencing preclinicalin vivoevaluation of mumps vaccine strain immunogenicity

“…Since 1970s the mumps has been controlled and prevented by vaccination with attenuated mumps vaccines, that resulted in significant reduction to nearly elimination of the disease from countries with high coverage rates of a 2-dose regimen. 10 However, resurgent mumps outbreaks among highly vaccinated population in recent years [11][12][13][14][15][16][17][18] in addition to relatively high rate of transient but unwanted neurological side effects by several vaccine strains 19 have raised many questions regarding the pathogenesis of MuV and vaccine efficacy, including considerations on the need to develop novel mumps vaccine candidates.…”

Genotyping of Mumps Virus Strains Detected in Kobe City from 1991 to 2012

“…Although mumps is preventable by vaccination, mumps outbreaks within highly vaccinated populations have recently been reported worldwide (11)(12)(13)(14)(15)(16). In the present study, the percentages of vaccinated patients with G1, G2, and H, which are the major genotypes detected since 2000, were 10z, 15z, and 25z, respectively.…”