2019
DOI: 10.1038/s41598-019-46998-9
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Molecular epidemiology of Klebsiella variicola obtained from different sources

Abstract: Klebsiella variicola is considered an emerging pathogen in humans and has been described in different environments. K. variicola belongs to Klebsiella pneumoniae complex, which has expanded the taxonomic classification and hindered epidemiological and evolutionary studies. The present work describes the molecular epidemiology of K. variicola based on MultiLocus Sequence Typing (MLST) developed for this purpose. In total, 226 genome… Show more

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Cited by 62 publications
(52 citation statements)
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“…Traditionally, K. variicola has been considered as susceptible to most antibiotic classes, but this description has change over time, due to an increase in the MDR- K. variicola reports [ 1 ]. In South America, there is a single report in Colombia describing a KPC-2-producing K. variicola strain, which was resistant to all β-lactams [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Traditionally, K. variicola has been considered as susceptible to most antibiotic classes, but this description has change over time, due to an increase in the MDR- K. variicola reports [ 1 ]. In South America, there is a single report in Colombia describing a KPC-2-producing K. variicola strain, which was resistant to all β-lactams [ 5 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among members of this complex, K. pneumoniae and K. variicola have been widely recognized as important opportunistic human pathogens commonly involved in hospital-acquired infections (HAIs) [ 2 , 3 ]. The clinical importance of these species has been associated with multidrug-resistance, mediated by the expression of extended-spectrum β-lactamases (ESBLs) and carbapenemases [ 4 , 5 ], and more recently with colistin resistance [ 6 , 7 ]. Lately, convergence of virulence and antibiotic-resistance has been reported in K. pneumoniae [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…Clinical strain collection was approved by the Human Research Ethics Committee from Universidade Federal de Minas Gerais (Brazil) under the protocol number ETIC 614/08 and written informed consent was obtained from each participant. E. hormaechei belongs to the Enterobacter cloacae complex and K. variicola is a member of the Klebsiella pneumoniae complex, as they share some biochemical and phenotypical features with E. cloacae and K. pneumoniae, respectively (Hoffmann et al, 2005;Barrios-Camacho et al, 2019). Because of this similarity, the species are frequently misclassified and the worldwide presence of these bacteria in human infections may be underestimated, although their relevance as clinical pathogens has been demonstrated (Long et al, 2017;Beyrouthy et al, 2018;Barrios-Camacho et al, 2019;Rodríguez-Medina et al, 2019).…”
Section: Clinical Isolatesmentioning
confidence: 99%
“…E. hormaechei belongs to the Enterobacter cloacae complex and K. variicola is a member of the Klebsiella pneumoniae complex, as they share some biochemical and phenotypical features with E. cloacae and K. pneumoniae, respectively (Hoffmann et al, 2005;Barrios-Camacho et al, 2019). Because of this similarity, the species are frequently misclassified and the worldwide presence of these bacteria in human infections may be underestimated, although their relevance as clinical pathogens has been demonstrated (Long et al, 2017;Beyrouthy et al, 2018;Barrios-Camacho et al, 2019;Rodríguez-Medina et al, 2019). The selection criteria of the isolates were the absence of a natural chloramphenicol-resistant phenotype, since the antibiotic was used as a selective marker of the pSB1C3 plasmid; the presence of the bla TEM−1 gene and the absence of carbapenemase genes.…”
Section: Clinical Isolatesmentioning
confidence: 99%
“…It typed as ST729 with four variant loci according to the K. pneumoniae MLST scheme. Although a K. variicola specific MLST scheme has been developed, it remains standard practice to use K. pneumoniae sensu stricto MLST typing for all members of the K. pneumoniae complex [56]. URMC-553 carried the bla LEN-24 beta-lactamase, but had no other antimicrobial resistance genes identified (Dataset S2).…”
Section: Resultsmentioning
confidence: 99%