2000
DOI: 10.1182/blood.v96.9.3279.h8003279_3279_3281
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Molecular evidence of organ-related transmission of Kaposi sarcoma–associated herpesvirus or human herpesvirus-8 in transplant patients

Abstract: In transplant patients, Kaposi sarcoma (KS)-associated herpesvirus or human herpesvirus-8 (HHV-8) infection is associated with the development of KS, primary effusion lymphoma and Castleman disease. Whether HHV-8 is either reactivated in the recipient or transmitted by the donor has been investigated so far only by serologic studies. Thus, we addressed the issue of HHV-8 transmission in the transplantation setting by molecular methods. We exploited the high level variability of the orf-K1 gene and the polymorp… Show more

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Cited by 51 publications
(30 citation statements)
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“…46,60 Other mechanisms are close contact modes of horizontal transmission in children 47,61 and potential transmission through the graft in OTRs. 48,62 Gene expression microarray profiling suggests that KS is a tumour of lymphatic endothelial lineage where the spindled endothelial cells are susceptible to both latent and lytic infection by HHV-8. 51,63 The HHV-8 genome comprises over more than 80 open reading frames (ORFs).…”
Section: Human Herpesvirus 8 and Kaposi Sarcomamentioning
confidence: 99%
“…46,60 Other mechanisms are close contact modes of horizontal transmission in children 47,61 and potential transmission through the graft in OTRs. 48,62 Gene expression microarray profiling suggests that KS is a tumour of lymphatic endothelial lineage where the spindled endothelial cells are susceptible to both latent and lytic infection by HHV-8. 51,63 The HHV-8 genome comprises over more than 80 open reading frames (ORFs).…”
Section: Human Herpesvirus 8 and Kaposi Sarcomamentioning
confidence: 99%
“…32,33 Furthermore, human herpesvirus (HHV)-8 may be related to the development of Kaposi's sarcoma. 34,35…”
Section: Risk Of Infections/cancermentioning
confidence: 99%
“…HHV 8 is the agent of Kaposi's sarcoma (KS). 34,35,55 Prevalence of latent infection with HHV 8 shows strong geographic variation among blood donors from France, Italy, Uganda and the USA. [55][56][57] Seroprevalence increases post-transplant, and the incidence of KS has been noted to be up to 8% to 12%.…”
Section: Hhvmentioning
confidence: 99%
“…Studies in cardiac transplant recipients demonstrated that HHV-8 viral load in peripheral blood lymphocytes increased significantly after transplantation and that the increased HHV-8 DNA levels were associated with the development of KS [14]. In one study of the 28 cases of post-transplant KS, 23 (82%) were because of HHV-8 reactivation and five (18%) were because of new infection from the transplanted organ [4]. Similar dynamics have been demonstrated between Epstein-Barr virus (EBV) infection and post-transplant lymphoproliferative disorder [15].…”
Section: Discussionmentioning
confidence: 70%
“…Serology studies indicated that HHV-8 transmission has occurred through solid-organ (kidney or liver) transplantation [3]. Molecular DNA analysis demonstrated HHV-8 transmission through kidney transplantation [4]. What was not determined in these studies was whether viral transmission occurred through infected cells of the transplanted organ or via infected lymphocytes contained within the organ.…”
Section: Introductionmentioning
confidence: 99%