1991
DOI: 10.1128/mmbr.55.4.621-648.1991
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Molecular genetics and pathogenesis of Clostridium perfringens.

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Cited by 275 publications
(148 citation statements)
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References 156 publications
(355 reference statements)
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“…Clostridium perfringens is an anaerobic, spore-forming, gram-positive bacillus that has been associated with outbreaks of acute, often severe diarrhea in human beings, dogs, horses, and cats. 2,[10][11][12][13] Clostridium perfringens isolates are classified as 1 of 5 toxigenic types (A-E) based on the production of 1 or more of 4 major toxins (alpha, beta, epsilon, and iota), although each bacterium also may express a subset of at least 10 other established toxins. 14 Expression of C perfringens enterotoxin (CPE), a well-characterized virulence factor, is coregulated with sporulation.…”
Section: T He Clinical Documentation Of Clostridium Perfringensmentioning
confidence: 99%
“…Clostridium perfringens is an anaerobic, spore-forming, gram-positive bacillus that has been associated with outbreaks of acute, often severe diarrhea in human beings, dogs, horses, and cats. 2,[10][11][12][13] Clostridium perfringens isolates are classified as 1 of 5 toxigenic types (A-E) based on the production of 1 or more of 4 major toxins (alpha, beta, epsilon, and iota), although each bacterium also may express a subset of at least 10 other established toxins. 14 Expression of C perfringens enterotoxin (CPE), a well-characterized virulence factor, is coregulated with sporulation.…”
Section: T He Clinical Documentation Of Clostridium Perfringensmentioning
confidence: 99%
“…Clostridium perfringens is an important cause of enteric disease in domestic animals [1][2][3][4][5]. Its virulence is based largely upon toxinogenesis [6,7], and production of four so-called major toxins is the basis for division of the species into types [6,[8][9][10][11] (Table 1).…”
Section: Introductionmentioning
confidence: 99%
“…The slight discrepancies among these data may arise either from a poor protection of the longer transcripts against mung bean nuclease digestion, or from artifacts of the primer extension reactions. In order to resolve these uncertainties we have scrutinized the potential promoter sequences for their consistency with consensus promoter sequences of Gram-positive bacteria [9,10]. The comparisons ( Fig.…”
Section: Resultsmentioning
confidence: 99%