Molecular investigations of β-thalassemic children in Erbil governorate

Hasan, Ahmad N.; Al-Attar, Mustafa S.

doi:10.1063/1.5004302

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…As for females, they were (89), or 44.5%. This result is in agreement with the study by [17]. Increasing the number of infected males over females may not mean that there is a genetic link to gender, but it may reflect families' interest in males more than females, in addition to the families' reluctance to visit hospitals when the disease appears in females, but we cannot neglect the possibility of gender cause [16].…”

Section: The Effect Of Gender Type On Carrying the Diseasesupporting

confidence: 91%

“…The others are from the blood type (AB), their number was (15) and their percentage was 7.5%. This result agrees with the study of [17] and disagree with the study of [18]. The reason may be due to the fact that there is a relationship between the transmission of the gene responsible for producing globulin on chromosome 16 and the other gene responsible for the type of antigen on the cell membrane of erythrocytes and responsible for the type of blood [7].…”

Section: The Effect Of the Blood Type Factor On The Infection Of The ...supporting

confidence: 61%

“…We find that the patient's chronological age has an effect on the infection, so the number of infected people was (111) out of the total number, as the infection rate was 55.5%. In the second level, the age group was (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) years, in which the number of infected people was (55) out of the total, and the infection rate was 27.5%. Hence, it is clear that the infection of the disease decreases with age, as we note that the lowest rate of infection was for the age group (41-50) years, which was 2% of infection.…”

Section: The Effect Of Age Factor Upon Getting the Diseasementioning

confidence: 99%

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Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba

Sahm

2022

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In the current study, 200 cases with thalassemia (111 males and 89 females) were used. Case samples were obtained from persons listed for Baquba Teaching Hospital / Hematology Center from November 1st, 2019 to January 31, 2020. Data were taken from patients' get-in hospital clinical reports through a form prepared for collecting data. The study aims to measure the impact of some factors on Thalassemia. The results showed that there is an effect of the relationship between chronological age and getting the disease, as it was found that the highest percentage was within the age group (1-10) years. It was also found that the number of males carry the disorder is higher than the number of infected females. Also, the effect of the type of Thalassemia factor on the infection of the disease shows that those who carry thalassemia major are more affected than those who carry thalassemia intermedia. The effect of the blood type factor on the infection rate shows that the highest number of infected people was those with blood type O. The effect of the disease history factor on the infection of the disease shows that the category (less than one year old) is more likely to get the disease. The effect of the factor of the number of infections in the family shows that the category (there are no previous infections in the family) are more numerous.

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Section: The Effect Of Gender Type On Carrying the Diseasesupporting

confidence: 91%

Section: The Effect Of the Blood Type Factor On The Infection Of The ...supporting

confidence: 61%

Section: The Effect Of Age Factor Upon Getting the Diseasementioning

confidence: 99%

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Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba

Sahm

2022

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“…Statistical analysis in thalassemia patients showed non-significant different increase (P >0.05) in WBC in both groups of thalassemia patients compared to healthy control group this result was in agreement with 24 . non-significant higher (P >0.05) in PLT, this result was disagreement with 25 . as presented in Table 1.…”

Section: Resultsmentioning

confidence: 62%

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

Al-Dedah¹,

Al-Wazni²,

Abbas³

et al. 2018

J Pure Appl Microbiol

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Thalassemia is a genetic disorder occurs as a result of the imbalance in the construction of haemoglobin chains cause haemolytic anaemia. This study was aimed to evaluate the serum level of immunological parameters (Transforming growth factor beta1, Interleukin-23) and hematological parameters in patients with alpha and beta thalassemia at Kerbala province. And was conducted at Kerbala Children's Hospital / Thalassemia Department / Kerbala Governorate during the period from November 2017 to May 2018. Seventy patients involved 48 beta thalassemia patients and 22 alpha thalassemia patients with age ranged 10-20 years old and ten matched healthy controls were enrolled in the study. Result exposed non-significant increase (p>0.05) in IL-23 and TGF-β in thalassemia patients compared with control group. In β-thalassemia patients the results of the current study indicated that non-significant positive correlation between IL-23 with WBC, there was non-significant positive correlation between TGF-β1 with WBC and PLT. As for β-thalassemia patients the present study showed non-significant positive correlation between IL-23 with Hb and WBC, and there was non-significant positive correlation between TGF-β1 with WBC. The study showed changes in the immunological parameters in patients with thalassemia of both types, as the serum level of both IL-23 and TGF-β1 were raised in addition to changes in hematological and Biochemical parameters.

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“…Among them, PCR test show a high accuracy in detecting H. pylori and genes of virulence factors. PCR has superiority on other diagnostic methods as it is simple, rapid and it is very accurate in detecting different genes and their mutations (5,17). In Iraq there is little attention about the genotyping of H. pylori isolate therefore this study aimed to detect h. pylori using PCR test, and to identify the prevalence of H. pylori vacA, cagA, and iceA virulence factors among gastrointestinal patients from Erbil city.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vacA, cagA, and iceA Virulence Factors of Helicobacter Pylori Isolated from Gastro-duodenal Patients

Salman¹,

Hawezy²

2020

JoBRC

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Back ground: Helicobacter pylori are bacteria colonize in the human epithelial cells of the gastrointestinal tract. Its infection causes different diseases, including chronic gastritis, peptic ulcers, gastric lymphoma and adenocarcinoma. H. pylori have many virulence factors attributing in one or more biological functions. Objective: Detecting the prevalence of virulence factor genes vacA, cagA, iceA among strain of H. pylori using molecular technique (PCR). Materials and methods: Sixty patients (27 male and 33 female), aged 18 and above included in the present study who showed signs and symptoms of H. pylori, and undergo endoscopy between period of November 2019 and February 2020. RUT and PCR test done to detect the presence of H. pylori infection, also PCR used to detect the three virulence factors. Results: Result showed that 44 patients, 21 (47.7%) male and 23 (52.3%) female were detected as positive H. pylori infections, among them 13 (29.5%) above 50 years, and 31 (70.4%) were below 50 years. While prevalence of the virulence factors vacA, cagA, and iceA were (100%), (84.1%), and (34.1%) respectively. Conclusion: It can be concluded that the frequency and prevalence of these genes are differed and showed significant differences among them. Also, PCR test is sensitive and accurate for detection of H. pylori virulence genes.

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Molecular investigations of β-thalassemic children in Erbil governorate

Cited by 3 publications

References 19 publications

Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba

Studying Some Factors That Increase the Risk of Thalassemia in The City of Baquba

Biochemical and Hematological Study with the Appreciation of some Immunological Parameters in Thalassemia Patients at Kerbala Province

Prevalence of vacA, cagA, and iceA Virulence Factors of Helicobacter Pylori Isolated from Gastro-duodenal Patients

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