Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562

Transcriptome analysis of phycocyanin inhibitory effects on SKOV-3 cell proliferation

“…High concentration phycocyanin showed remarkable inhibition on lung adenocarcinoma cell growth in vitro (Zhang, 2005). Phycocyanin also inhibited the growth of human leukemia cells HL-60, K-562 and U-937 on a dose-dependent manner with higher phycocyanin concentration leading to stronger inhibition (Subhashini et al, 2004). In this research, the inhibition effect of phycocyanin on the growth of SKOV-3 cell was measured using CCK-8 assay.…”

The Biliprotein C-Phycocyanin Modulates the DNA Damage Response in Lymphocytes from Nuclear Power Plant Workers

“…It has been shown that visible light, absorbed by the tetrapyrrolic chromophores of phycobiliproteins, can generate reactivate oxygen species (ROS), such as hydroxyl radical and singlet oxygen, which induce oxidative damage to DNA. The photosensitizing properties of C-PC may also contribute to the apoptotic effects of the protein in cancerogenic cell lines (Roy et al, 2007;Subhashini et al, 2004) and macrophages (Reddi et al, 2003). Apoptotic activity, however, is evident only for higher protein concentrations (>20 μM) and longer incubation times of the cells with the protein (>24h).…”

Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

“…The biological and pharmacological properties of Spirulina are attributed mainly to calcium-spirulan (Ca-SP) and C-phycocyanin (C-PC) (Subhashini et al, 2004). Ca-SP, a sulfated polysaccharide consists of rhamnose, ribose, mannose, fructose, galactose, xylose, glucose, glucuronic acid, galacturonic acid, sulfate and calcium.…”