Molecular mechanisms involved in varicocele-associated infertility

Sheehan, Matthew M.; Ramasamy, Ranjith; Lamb, Dolores J.

doi:10.1007/s10815-014-0200-9

Cited by 77 publications

(72 citation statements)

References 45 publications

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“…Factors that may contribute to the pathogenesis of varicocele include hypoperfusion leading to hypoxia, heat stress, oxidative stress, hormonal imbalances, and exogenous toxicants. 1 However, the exact mechanism underlying varicocele-associated testicular dysfunction and infertility remains unclear. 2 Proteomics is emerging as a new frontier in male infertility research and is being extensively used to investigate protein alterations in different disease states.…”

Section: Resultsmentioning

confidence: 99%

Differential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele

Agarwal

Sharma

Durairajanayagam

et al. 2015

Urology

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Section: Resultsmentioning

confidence: 99%

Differential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele

Agarwal

Sharma

Durairajanayagam

et al. 2015

Urology

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“…Anatomical abnormalities, such as varicocele, semen outflow tract obstruction, or neurological disorders of ejaculation may cause abnormal spermatogenesis and failure in sperm function. Varicocele is the most prevalent abnormal physical finding and most common surgically correctable risk factor for male infertility (2,3). Varicocele is a pathologic enlargement of the pampiniform venous plexus within the spermatic cord.…”

Section: Introductionmentioning

confidence: 99%

Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele

Salimi¹,

Fazeli²,

Khosravi³

et al. 2016

Avicenna J Med Biochem

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“…The following five mechanisms seem to contribute to the impact of varicocele on testicular function, reduced blood flow leading to hypoxia, thermal stress, oxidative stress, hormonal imbalance and detoxification (27).…”

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confidence: 99%

Infertility-Related Risk Factors: A Systematic Review

Deyhoul¹,

Mohamaddoost²,

Hosseini³

2017

IJWHR

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IntroductionOxford English Dictionary defines the word "infertile" or barren as "inability to give birth or procreate. " This definition refers to the "sterilization mode rather than visualization difficulty" and presents so many clinical perspectives (1). According to the reports of the International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO), "infertility" is a couple's failure in pregnancy after 12 months of unprotected sexual intercourse and pregnancy attempts. Infertility is a global problem affecting people around the world whose cause and importance may vary according to the geographical location and socio-economic condition. According to the statistics, annually 60-80 million couples around the world suffer from infertility (2). The estimated fertility rate in Canada is 11.5% to 15.7%. One out of seven English couples suffers from fertility problems (3). The number of couples affected by infertility has increased from 42.0 million people (39.6 million people, 44.8 million people) in 1990 to 48.5 million people (45.0 million people, 52.6 million people) in 2010 (4). Ten to 12% of couples around the world are suffering from infertility in half of which, the man is infertile. The estimates show that in 35%-40% of cases, the man is infertile and in 35%-40% of cases, the woman is infertile and in 20%-30% of cases, it is related to the combination of other factors (5). Infertility occurs once pregnancies are ended up with abortion (ASR) or the delivery of a child with multiple hereditary diseases (6). Infertility diagnosis is different and may include the evaluation of sperm quality; Mormons, and analysis of imaging of uterus and fallopian tubes. According to the medical diagnosis, infertility may be treated by reproductive surgery, prescribing hormones or applying infertility technologies (2). Infertility awareness, like men and women's awareness of risk factors, is the first step in protecting pregnancy in lifestyle modification. Knowledge and awareness of fertility depends on education rather than personal fertility or motherhood and fatherhood experience. Health improving strategies started with educational interventions (3). Secondary infertility refers to a state in which pregnancy does not occur after one year (in some epidemiologic studies 2 years) of unprotected sexual intercourse despite at least one pregnancy in the past. Women with secondary infertility cannot give birth to alive child (7). Infertility may result from a wide range of abnormalities one or both of which exist. However, infertility is not much different in people and it can have a variety of causes (8). The primary and secondary causes of infertility are reviewed in this study. This study examines the following points: primary causes of infertility, such as genetic factors, hormonal disorders, genetic disorders, congenital defects or reproductive system diseases; secondary factors, including lifestyle related factors, such as obesity, diet, smoking, alcohol consumption an...

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Molecular mechanisms involved in varicocele-associated infertility

Cited by 77 publications

References 45 publications

Differential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele

Differential Proteomic Profiling of Spermatozoal Proteins of Infertile Men With Unilateral or Bilateral Varicocele

Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele

Infertility-Related Risk Factors: A Systematic Review

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