Molecular modelling and docking analysis of pleurocidin (an antimicrobial peptide) like peptides with enterotoxin H from Klebsilla pneumonia

Bupesh, Giridharan; Nandini, M.; Vasanth, Sakthivel; Vijayakumar, T.; Amutha, C.; Prabhu, K; Balachnadar, Vellingiri

doi:10.6026/97320630015838

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Ho et al, 2016 revealed also the effect of an amidated hybrid of the flounder pleurocidin and the frog dermaseptin (P-Der) on the inhibition of the bacterial catabolic processes. In a separate investigation, the utilization of molecular modeling and docking analysis data revealed the ability of pleurocidin-like peptides to selectively target enterotoxin H derived from Klebsiella pneumoniae, which suggests the potential of these peptides to interact with Frontiers in Pharmacology frontiersin.org non-membrane components (Bupesh et al, 2019). Collectively, these reports provide strong support for the assertions regarding the impact of pleurocidin and its effects on diverse intracellular processes, including the induction of apoptosis.…”

Section: Frontiers In Pharmacologymentioning

confidence: 62%

From antimicrobial to anticancer: unraveling the potential of pleurocidin and pleurocidin-derived peptides in the treatment of cancers

Piktel,

Wnorowska,

Gorbacz-Konończuk

et al. 2024

Front. Pharmacol.

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Antimicrobial peptides (AMPs), commonly referred to as host defense peptides, are found in a wide range of organisms, including bacteria, plants, and both vertebrate and invertebrate animals. They function as an initial defense mechanism against pathogenic microorganisms, modulate immune responses, and in specific instances, confer protection against the onset of cancer. Pleurocidin (Ple) is a linear antimicrobial peptide with amphipathic α-helical conformation, isolated originally from the winter flounder (Pleuronectes americanus), notable for its wide-ranging effectiveness against both bacteria and fungi. While the majority of research on pleurocidin’s biological characteristics has primarily focused on deciphering its mechanisms of interaction with the biological membranes of pathogenic bacteria and host cells, as well as investigating its modes of killing activities, there is a growing body of evidence suggesting that pleurocidin and pleurocidin-derived analogs might be effectively employed as anti-cancer agents against breast carcinoma and leukemia due to their potent cytotoxic properties and selectivity towards cancer cells. Notably, some characteristics of pleurocidin observed in microbiological investigations of this compound could be effectively applied in examining the anti-cancer capabilities of Ple-like derivatives. This review provides a comprehensive overview of the literature on the biological activities of pleurocidin, pleurocidin-derived peptides, pleurocidin-containing hybrid peptides, and nanosystems. The primary emphasis is on elucidating the range of activities exhibited by these compounds, evaluating their potential therapeutic applications, assessing their safety profile, and identifying any limits observed thus far. This paper will also discuss potential areas for further investigation into the anti-cancer effects of Ple and its derivatives, drawing insights from microbiological research.

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Section: Frontiers In Pharmacologymentioning

confidence: 62%

From antimicrobial to anticancer: unraveling the potential of pleurocidin and pleurocidin-derived peptides in the treatment of cancers

Piktel,

Wnorowska,

Gorbacz-Konończuk

et al. 2024

Front. Pharmacol.

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Identification of novel potent pancreatic lipase inhibitors from Ficus racemosa

Anand¹,

Bharathi²,

Bupesh³

et al. 2021

Biomedicine

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Introduction and Aim: Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide. It is considered to be main reason for a number of physiological changes that resulting in many metabolic disorders such as cardiovascular diseases, diabetes, musculoskeletal disorders and various cancer types. Obesity develops from long-termed physiological imbalances in energy expenditure.. One of the therapeutic strategies in managing obesity is inhibition of pancreatic lipase, a key enzyme responsible for the digestion of fats and triglycerides. The aim of the present study was to synthesize silver nanoparticles (Ag-NP) from Ficus racemosa fruit extract and to analyze its activity on pancreatic lipase enzyme using spectroscopic, in vitro and in silico methods. Materials and Methods: The phytoconstituent were separated in Ficus racemosa fruit extract by thin layer chromatography technique. The bioactive compound was also identified by gas chromatography-mass spectrometry analysis. Pancreatic lipase inhibition assay was performed in vitro and confirmed by molecular docking analysis. Results: The F. racemosa fruit showed the highest pancreatic lipase inhibitory activity. Molecular docking studies also exhibited good binding affinity of compounds (Diethyl Phthalate) with pancreatic lipase enzymes. Conclusion: Finally, it is concluded that further derivation of such compounds could serve as the new templates for obesity.

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Molecular modelling and docking analysis of pleurocidin (an antimicrobial peptide) like peptides with enterotoxin H from Klebsilla pneumonia

Cited by 2 publications

References 29 publications

From antimicrobial to anticancer: unraveling the potential of pleurocidin and pleurocidin-derived peptides in the treatment of cancers

From antimicrobial to anticancer: unraveling the potential of pleurocidin and pleurocidin-derived peptides in the treatment of cancers

Identification of novel potent pancreatic lipase inhibitors from Ficus racemosa

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