Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Kim, Ju‐Ha; Hwang, Jisung; Jung, Ji Hoon; Lee, Hyo‐Jung; Lee, Dong Hoon

doi:10.1186/s12943-019-1110-3

Cited by 80 publications

(62 citation statements)

References 218 publications

(268 reference statements)

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“…Our study has verified 37 keloids and 37 normal samples, which can more accurately demonstrate the significant dif- by activating Wnt/β-catenin signaling pathway. [29][30][31] COL5A1 chains interact to form collagen types V, the fibrillar collagens relating to fibrosis. 32 These two circRNAs have no reported in keloid and all belonging to Wnt signal pathway, which is important in keloid formation and development.…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high‐throughput sequencing

Zhang

Liu

et al. 2021

Dermatologic Therapy

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Keloid is a kind of pathological skin scar with unclear molecular pathology. Circular RNAs (circRNAs) are involved in the occurrence and development of many diseases; however, their relationship with keloid is not well understood. To investigate the involvement of dysregulated circRNAs in keloid. Thirty-seven keloids and 37 normal skin tissues were collected, and the changes of circRNAs, microRNAs (miRNAs) and mRNAs in 3 keloids and 3 normal samples by high-throughput sequencing were detected first. Based on the circRNA-miRNA-mRNA interaction network construction, gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis combining several signaling pathways associated with keloid formation and progression, the circRNAs required further verification were screened out. The expression levels of the selected circRNAs were verified in 37 keloids and 37 normal skin tissues using quantitative real-time polymerase chain reaction (QPCR). The interaction of candidate circRNA and its predicted binding miRNA was tested by dualluciferase reporter gene experiment. Compared with normal controls, there was an average of 120 and 12 circRNAs, 44 and 63 miRNAs, 656 and 156 mRNAs were upregulated and downregulated, respectively, in keloids. According to the analysis of bioinformation, six circRNAs were picked out. The QPCR validation results of two upregulated circRNAs (hsa_circ_0001320 and circCOL5A1) were consistent with previous sequencing results. The interaction between hsa_circ_0001320 and miR-574-5p was confirmed. This study makes it clear that the abnormal expression of cir-cRNAs may be related to the pathological process of keloid.

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Section: Discussionmentioning

confidence: 99%

Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high‐throughput sequencing

Zhang

Liu

et al. 2021

Dermatologic Therapy

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“…Recently, forkhead box protein P2 (FOXP2) has been verified to be a tumor suppressor ( 26 ). Notably, FOXP2 suppresses the transcriptional activity of numerous downstream target genes, via its zinc finger domain, further affecting tumor progression ( 26 , 27 ). In addition, FOXP2 was found to be essential for the suppression of cell growth by regulating p21 in osteosarcoma cells ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis

et al. 2021

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An increasing number of studies have demonstrated that long non-coding (lnc)RNAs are associated with tumor invasion, metastasis and the prognosis of patients with a variety of different tumors. However, the roles of lncRNA prostate androgen regulated transcript 1 (PART1) in esophageal squamous cell carcinoma (ESCC) remain unknown. In the present study, reverse transcription-quantitative PCR was performed to investigate the levels of PART1, SRY-box transcription factor 6 (SOX6) and miR-18a-5p in ESCC tissues and cells. The functions of PART1 in ESCC were demonstrated using Cell Counting Kit-8 and Matrigel assays. Promoter activity and dual-luciferase reporter assays, RNA immunoprecipitation and western blot analyses were also used to determine the potential mechanisms of PART1 in ESCC cell lines. It was found that PART1 and SOX6 were both downregulated in ESCC tissues and cells, and their low expression levels were associated with TNM stage, lymph node metastasis and poor prognosis in patients with ESCC. Forkhead box protein P2 (FOXP2) exhibited low expression level in ESCC tissues, and its expression was positively correlated with PART1 expression level in ESCC tissues. FOXP2 was found to bind to the promoter region of PART1 to regulate its expression in ESCC cells. Functionally, PART1 overexpression suppressed cell proliferation and invasion, whereas PART1 downregulation promoted cell proliferation and invasion in the ESCC cell lines. Mechanistically, PART1 functions as a competing endogenous (ce)RNA by sponging miR-18a-5p, resulting in the upregulation of the downstream target gene, SOX6, coupled with the inactivation of the β-catenin/c-myc signaling axis, to suppress ESCC cell proliferation and invasion. In conclusion, data from the present study unveil a potential ceRNA regulatory pathway, in which PART1 affects SOX6 expression level by sponging miR-18a-5p, to ultimately suppress ESCC development and progression.

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“…A study shows that FOXP1 is a key factor in PRMT5-induced breast cancer stem cells and PRMT5 can be recruited to the FOXP1 promoter to facilitates recruitment of H3R2me2s, SET1 and H3K4me3 [81]. FOXP1 is a member of the forkhead box transcription factor family and is associated with cancer cell stemness [82]. FOXP1 can also promote tumor proliferation and migration [83].…”

Section: Prmt5 and Drug Resistancementioning

confidence: 99%

Histone methyltransferase and drug resistance in cancers

Yang

Zhang

et al. 2020

J Exp Clin Cancer Res

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A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance might involved in changes in gene expression without changing genotypes, which is similar to epigenetic modification. Some studies indicated that targeting histone methyltransferase can reverse drug resistance. Hence, the use of histone methyltransferase inhibitors or histone demethylase inhibitors opens new therapeutic approaches for cancer treatment. While the relationship between histone methyltransferase and tumor resistance has been determined, there is a lack of updated review on the association between them. In this review, we summarized the mechanisms of histone methyltransferases in cancer drug resistance and the therapeutic strategies of targeting histone methyltransferase to reverse drug resistance.

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Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Cited by 80 publications

References 218 publications

Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high‐throughput sequencing

Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high‐throughput sequencing

lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis

Histone methyltransferase and drug resistance in cancers

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