Molecular structure and dynamical properties of niosome bilayers with and without cholesterol incorporation: A molecular dynamics simulation study

Ritwiset, Aksornnarong; Krongsuk, Sriprajak; Johns, Jeffrey

doi:10.1016/j.apsusc.2016.02.092

Cited by 45 publications

(26 citation statements)

References 41 publications

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“…31 According to Figure 3-f, the estimated dimension of each bilayer is 3.35±0.15 nm and it is in agreement with molecular simulations and experimental data where the area per molecule of Span 20 is approximately 22Å 2 . 32 This result is also in agreement with the thickness of some reported bilayers: 1) 4.18 nm, 29 composed of Span 60 and cholesterol, 2) 3.49 nm, 29,33 composed of Span 80 and cholesterol and 3) 3.53 nm, 33 composed of DOPC (1,2dioleoyl-sn-glycero-3-phosphocholine) and cholesterol.…”

Section: Electronic Microscopy Characterization Of Niosome Bilayerssupporting

confidence: 91%

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Rapid on-Chip Assembly of Niosomes: Batch versus Continuous Flow Reactors

García-Salinas

Himawan

Mendoza

et al. 2018

ACS Appl. Mater. Interfaces

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The large-scale continuous production of niosomes remains challenging. The inherent drawbacks of batch processes such as large particle polydispersity and reduced batch-to-batch reproducibility are here overcome by using commercially available microfluidic reactors. Compared to the traditional batch-based film hydration method, herein, we demonstrate that it is possible to carry out the homogeneous, large-scale (up to 120 mg/min) production of niosomes using two different synthesis techniques (the thin film hydration method and the emulsification technique). Niosomes particle size can be controlled depending on the need by varying the synthesis temperature. The high cytocompatibility of the resulting niosomes was also demonstrated in this work on three different somatic cell lines. For the first time, the structure of the niosome multilamellar shell was also elucidated using high-resolution transmission electron microscopy (HR-STEM) as well as their colloidal stability over time (6 weeks) under different storage conditions. The morphology of cryo-protected or as-made niosomes was also evaluated by HR-STEM after freeze-drying. Finally, the dual ability of those synthetic, nonionic, surfactant-based vesicles to carry both hydrophilic and hydrophobic molecules was also here demonstrated by using laser scanning confocal microscopy.

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Section: Electronic Microscopy Characterization Of Niosome Bilayerssupporting

confidence: 91%

“…Bilayer thickness determination by imaging profile (red dashed line) and interpretation of the Span 20/Cholesterol bilayer according to molecular simulations. 29 emulsification method. The collapsed structure of the niosome after drying confirms the presence of a multi-lamellar shell of approx.…”

Section: Electronic Microscopy Characterization Of Niosome Bilayersmentioning

confidence: 99%

Rapid on-Chip Assembly of Niosomes: Batch versus Continuous Flow Reactors

García-Salinas

Himawan

Mendoza

et al. 2018

ACS Appl. Mater. Interfaces

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“…16 Cholesterol is a vital component of cell membranes accounting for over 20% of the plasma membrane lipids and, due to its biocompatibility and biodegradability, cholesterol is oen used in studies of drug delivery systems involving nanoparticles. 17,18 Modication with cholesterol results in signicant improvement of the cellular uptake of polymers for drug delivery applications. 19 Octadecanoic acid (OA) is a hydrophobic saturated fatty acid which has been used as a safe biodegradable dietary additive.…”

Section: Introductionmentioning

confidence: 99%

In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

Zhu

et al. 2017

RSC Adv.

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“…Due to C18 hydrocarbon chain length of Span/Tween 60, multilamellar vesicles (MLVs) were formed in the presence of 30, 40 and 50 M percentag of cholesterol. Increment the amount of cholesterol from 30 to 40 M percent often resulted in larger niosomes and maybe increased in the number of lipid bilayers [32]. An increase in the aqueous PEN concentration from 3 to 5% leads to significant size reduction of NSVs in prepared ST60/Chol niosomes ( p < 0.05).…”

Section: Discussionmentioning

confidence: 99%