Molecularly Imprinted Polymer Based GCE for Ultra-sensitive Voltammetric and Potentiometric Bio Sensing of Topiramate

Khalifa, Mohamed E.; Ali, Tamer Awad; Abdallah, A. M.

doi:10.2116/analsci.20p313

Cited by 9 publications

(2 citation statements)

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“…So, MIP electrochemical sensors based on Fe 3 O 4 →GO-SiO 2 →AuNPs are performed by three electrodes for detecting biological molecules, as well as drugs. A carbon paste electrode (CPE) modified by metal nanomaterials and MIP composite is used as the working electrode, platinum is employed as the auxiliary electrode, and Ag/AgCl, KCl is used as the reference electrode (Khalifa et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A novel electrochemical sensor based on metal nanoparticles and molecularly imprinted polymer nanocomposite with biological applications

Shaker

Vardini

Es’haghi

et al. 2022

MGPB

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Metal nanoparticles trapped in a biopolymer composite due to electrical conductivity properties improve electrochemical sensors with biomedical and environmental applications. The study aims are to design a novel molecularly imprinted polymer (MIP) composite based on magnetic graphene oxide (Fe3O4@GO) modified silica (SiO2) and gold nanoparticles (AuNPs) to electrochemical detect serotonin (5-hydroxytryptamine, 5-HT). A suitable amount of 5-HT is effective on motivational functions and the environment because it is a serotonergic neurotransmitter. But the desired nanocomposite may have a relatively low recognition, therefore must be in choosing the type of functional monomer be careful. In this regard, the design of the electrochemical sensor began by synthesis of Fe3O4@GO-SiO2@AuNPs nanocomposite. Then, MIP electropolymerization was carried out by using p-aminothiophenol (PATP)-functionalized Fe3O4@GO-SiO2@AuNPs nanocomposite in the presence of 5HT as a template molecule. Electrochemical polymerization of MIP nanocomposite was developed using cyclic voltammetry (CV) and the electrochemical properties of 5-HT were studied use differential pulse voltammetry (DPV) technology in the 5HT solution. After optimization of preparation and measurement conditions on the designed sensor, the 5HT concentration range is 0.1 μM to 10 μM linearly, and the detection limit was 1 × 10-5 μM (S / N = 3). The wide concentration range and low detection limit were presented metal nanoparticles functionalized MIP with appropriate functional monomer have a great effect on the performance of the sensor. Furthermore, PATP-functionalized metal nanoparticles increase the conductivity and recognition of the prepared MIP electrochemical sensor to the quantification of 5-HT in biological samples with high selectivity and recovery.

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Section: Introductionmentioning

confidence: 99%

A novel electrochemical sensor based on metal nanoparticles and molecularly imprinted polymer nanocomposite with biological applications

Shaker

Vardini

Es’haghi

et al. 2022

MGPB

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show abstract

“…These properties make MIP a potential alternative to antibodies and DNA aptamers. [22][23][24][25][26][27] Over the past decades, MIP-based technologies have revealed great prospects in the detection of viruses, organic molecules and proteins. [28][29][30] Most recently, for the rst time, Syritski et al 31 reported an interesting MIP-based sensor to electrochemically detect the SARS-CoV2 antigen using m-phenylenediamine (mPD) as the functional monomer of electropolymerization, and the resulting sensor showed a low detection limit of 15 fM.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive electrochemical determination of the SARS-COV-2 antigen based on a gold/graphene imprinted poly-arginine sensor

2021

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Applications of electrochemical techniques for determination of anticoagulant drug (Rivaroxaban) in real samples

Abdallah

Saher

Molouk

et al. 2022

Biosensors and Bioelectronics

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Molecularly Imprinted Polymer Based GCE for Ultra-sensitive Voltammetric and Potentiometric Bio Sensing of Topiramate

Cited by 9 publications

References 50 publications

A novel electrochemical sensor based on metal nanoparticles and molecularly imprinted polymer nanocomposite with biological applications

A novel electrochemical sensor based on metal nanoparticles and molecularly imprinted polymer nanocomposite with biological applications

Highly sensitive electrochemical determination of the SARS-COV-2 antigen based on a gold/graphene imprinted poly-arginine sensor

Applications of electrochemical techniques for determination of anticoagulant drug (Rivaroxaban) in real samples

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