Molecularly imprinted polymers based materials and their applications in chromatographic and electrophoretic separations

Song, Zhihua; Li, Jinhua; Lü, Wenhui; Li, Bowei; Yang, Gangqiang; Bi, Yi; Arabi, Maryam; Wang, Xiaoyan; Ma, Jiping; Chen, Lingxin

doi:10.1016/j.trac.2021.116504

Cited by 99 publications

(41 citation statements)

References 136 publications

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“…MIP synthesis includes several polymerization methods such as ground bulk which generates irregular size and shape particles; precipitation improves this situation with no control over molecular weight distribution; emulsion increases monodispersity, iniferter for a fine-tuned reaction advancement, and core–shell for smart/responsive particles. 44,87,95,147,148,152…”

Section: Molecularly Imprinted Polymers Synthesis As a Strategy For S...mentioning

confidence: 99%

“…24–26 These new platforms will pave the way towards an outstanding sensitive and selective performance that will undoubtedly advance future developments in food safety, environmental monitoring, and healthcare fields. 2,10,27,28,146,147,152…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26] These new platforms will pave the way towards an outstanding sensitive and selective performance that will undoubtedly advance future developments in food safety, environmental monitoring, and healthcare elds. 2,10,27,28,146,147,152 One possible way to create such a novel sensing platform is to take advantage of biomolecules attached in electronic devices (see Fig. 1 for the schematic illustration).…”

Section: Introductionmentioning

confidence: 99%

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Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

et al. 2022

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Section: Molecularly Imprinted Polymers Synthesis As a Strategy For S...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

et al. 2022

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“…In general, the preparation of MIPs requires the single-template imprints of targeted molecules or similar molecules that can bind to the functional groups of functional monomers through covalent or noncovalent molecular interactions. Template molecules can be removed from prepared polymers, leaving imprinted 3D skeleton cavities for the specific rebinding of target molecules [ 10 , 11 ]. The ability of MIPs to recognize targeted analyte molecules is influenced by many factors, including ionic strength, pH, solution polarity and polymer type and size [ 12 ].…”

Section: The Development Of Molecularly Imprinted Polymer–aptamermentioning

confidence: 99%

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Zhou

Liu

2022

Biosensors

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Molecular imprinting–aptamer techniques exhibit the advantages of molecular imprinting and aptamer technology. Hybrids of molecularly imprinted polymer–aptamer (MIP–aptamer) prepared by this technique have higher stability, binding affinity and superior selectivity than conventional molecularly imprinted polymers or aptamers. In recent years, molecular imprinting–aptamer technologies have attracted considerable interest for the selective recognition of target molecules in complex sample matrices and have been used in molecular recognition such as antibiotics, proteins, viruses and pesticides. This review introduced the development of molecular imprinting–aptamer-combining technologies and summarized the mechanism of MIP–aptamer formation. Meanwhile, we discussed the challenges in preparing MIP–aptamer. Finally, we summarized the application of MIP–aptamer to the molecular recognition in disease diagnosis, environmental analysis, food safety and other fields.

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“…In this context, a wealth of different synthetic strategies were presented to facilitate the design of efficient, imprinted materials for the application of interest. More detailed explanations of the synthesis, application, and limitations of MIPs can be found recent reviews [ 2 , 12 , 14 , 17 , 24 , 27 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Biomimetic Electrochemical Assemblies

et al. 2022

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Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors.

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Molecularly imprinted polymers based materials and their applications in chromatographic and electrophoretic separations

Cited by 99 publications

References 136 publications

Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

Molecularly imprinted polymersviareversible addition–fragmentation chain-transfer synthesis in sensing and environmental applications

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Artificial Biomimetic Electrochemical Assemblies

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