Molybdate induces thermotolerance in yeast

Tiligada, Ekaterini; Miligkos, V.; Ypsilantis, E.; Papamichael, Konstantinos; Delitheos, A.

doi:10.1046/j.1365-2672.1999.00581.x

Cited by 17 publications

(22 citation statements)

References 20 publications

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“…One such case can be attributed to Cryptococcus laurentii , which normally does not grow at 37°C, but thermotolerant strains have increasingly been associated with disease in extremely immunosuppressed hosts (24). Experimentally, heat tolerance can be induced in Saccharomyces cerevisiae (25) and in the entomopathogen Metarhizium anisopliae without loss of its pathogenic capability (26). …”

Section: Fungi Temperature Tolerance and Endothermymentioning

confidence: 99%

Global Warming Will Bring New Fungal Diseases for Mammals

García-Solache

Casadevall

2010

mBio

289

194

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Fungi are major pathogens of plants, other fungi, rotifers, insects, and amphibians, but relatively few cause disease in mammals. Fungi became important human pathogens only in the late 20th century, primarily in hosts with impaired immunity as a consequence of medical interventions or HIV infection. The relatively high resistance of mammals has been attributed to a combination of a complex immune system and endothermy. Mammals maintain high body temperatures relative to environmental temperatures, creating a thermally restrictive ambient for the majority of fungi. According to this view, protection given by endothermy requires a temperature gradient between those of mammals and the environment. We hypothesize that global warming will increase the prevalence of fungal diseases in mammals by two mechanisms: (i) increasing the geographic range of currently pathogenic species and (ii) selecting for adaptive thermotolerance for species with significant pathogenic potential but currently not pathogenic by virtue of being restricted by mammalian temperatures.

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Section: Fungi Temperature Tolerance and Endothermymentioning

confidence: 99%

Global Warming Will Bring New Fungal Diseases for Mammals

García-Solache

Casadevall

2010

mBio

289

194

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“…Exposure of yeast cells to classic anticancer agents has been shown to provoke phenotypic alterations [11] and the cellular adaptive response to stress [12] in a dosagedependent fashion. The propagation of signals determines the functional integration of deleterious stimuli and cell survival or death [13]. Moreover, the critical role of the microenvironment in providing cells with survival signals should be taken into consideration [14].…”

Section: The Yeast Paradigmmentioning

confidence: 99%

Nuclear Translocation During the Cross-Talk Between Cellular Stress, Cell Cycle and Anticancer Agents

Tiligada¹

2006

CMC

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The function of many endogenous molecules in all eukaryotic cells depends on their subcellular localisation, being active when localized in one cellular compartment and inactive in another. Translocation or re-localization of mislocalized components in the optimal subcellular site may contribute to the development of novel cancer therapies and to the re-evaluation of conventional treatment. For instance, various agents are able to entrap cytoplasmic anti-apoptotic pathways to the nucleus, thus activating apoptosis. Moreover, amongst the factors identified so far, the optimal location of the tumor suppressor p53 for promoting cell arrest and apoptosis seems to be the nucleus, while the nuclear factor kappa B (NFkappaB) is desirable to stay in the cytoplasm. Thus, the mechanisms of nuclear translocation of endogenous signaling components, like p53, NFkappaB and various heat shock proteins (HSPs), may serve as targets for pharmacological intervention, without excluding the possible role of uptake and active transport into the nucleus of extracellular proteins.

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“…On the contrary, acquisition of thermotolerance by the phosphatase inhibitor sodium molybdate did not rely on nascent protein synthesis (Tiligada et al . ). Other compounds, such as 17‐ β ‐estradiol (Papamichael et al .…”

Section: Discussionmentioning

confidence: 97%

“…Viability was determined by counting the blue‐stained dead cells and their unstained viable counterparts, and expressed as the percentage of the viable cells in each culture (Tiligada et al . ). Yeast cells were viable before exposure to HS independently of the treatment.…”

Section: Methodsmentioning

confidence: 97%

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A subset of histamine receptor ligands improve thermotolerance of the yeast Saccharomyces cerevisiae

2012

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Aims: Histamine interacts with the stress response in eukaryotes. This study investigated the effects of antihistamines on the heat shock (HS) response in yeast, thereby exploring their functions in a well-established histamine receptor (H x R)-free model. Methods and Results: Stress response was evaluated by determining growth and viability of postlogarithmic phase grown yeast cultures after HS at 53°C for 30 min. The effects of H x R ligands were investigated following short-and long-term administration. The H 1 R antagonist dimethindene exerted doserelated antifungal actions, whereas the H 2 R antagonist ranitidine failed to elicit any effect. In contrast, the H 3/4 R and H 4 R ligands, thioperamide and JNJ7777120, respectively, induced the thermotolerant phenotype. The circumvention of thermotolerance by cycloheximide and the induction of Hsp70 and Hsp104 expression indicated the contribution of de novo protein synthesis in the adaptive process, likely directed towards alterations in Hsp expression. Conclusions: The data provide evidence for the differential function of H x R ligands in thermotolerance induction in yeast. Significance and Impact of the Study: First demonstration of the action of antihistamines in the HS response in yeast. The work supports the potential H x R-independent functions of histaminergic compounds in fungal adaptation and stimulates research on the prospect of their exploitation in eukaryotic (patho)physiology.

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Molybdate induces thermotolerance in yeast

Cited by 17 publications

References 20 publications

Global Warming Will Bring New Fungal Diseases for Mammals

Global Warming Will Bring New Fungal Diseases for Mammals

Nuclear Translocation During the Cross-Talk Between Cellular Stress, Cell Cycle and Anticancer Agents

A subset of histamine receptor ligands improve thermotolerance of the yeast Saccharomyces cerevisiae

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