Mometasone furoate nasal spray: a systematic review

Abstract

The inflammatory diseases of the nose, rhino-pharynx and paranasal sinuses (allergic and non allergic rhinitis, NARES; rhinosinusitis with/without nasal polyposis, adenoidal hypertrophy with/without middle ear involvement) clinically manifest themselves with symptoms and complications severely affecting quality of life and health care expenditure. Intranasal administration of corticosteroids, being fast, simple, and not requiring cooperation, is the preferred way to treat the patients, to optimize their quality of life, at the same time minimizing the risk of exacerbations and complications. Among the different topical steroids available on the market, we performed a comparative analysis in terms of effectiveness and safety between mometasone furoate (MF) and its main competitors. Searching through Pub Med and Google Scholar and using as entries “mometasone furoate”, “rhinitis”, “sinusitis”, “asthma”, “polyposis”, “otitis media with effusion”, and “adenoid hypertrophy” we found 344 articles, 300 of which met the eligibility criteria. Taking into account relevance and date of publication, a sample of 40 articles was considered for the review. MF effectiveness for treatment and/or prophylaxis of nasal symptoms in seasonal and perennial allergic rhinitis has been fully established with a level of evidence Ia. Even though it has not been assessed for MF in particular, topical steroids are the most appropriate treatment in mixed rhinitis and NARES. In acute rhinosinusitis (ARS) evidences support their use as mono-therapy or as adjuvant to antibiotics for reducing the recurrence rate, and decrease the usage of related prescriptions and medical consultations. In chronic rhinosinusitis (CRS) with Nasal polyposis, MF reduces polyps size, nasal congestion, improves quality of life and sense of smell and it is also effective in the treatment of daytime cough. The topical use of MF has great efficacy in the management of adenoidal hypertrophy and otitis media of atopic children. As regards the safety, MF has demonstrated an excellent safety profile: pregnant women can safely use it; no systemic effects on growth velocity and adrenal suppression have been shown; no changes in epithelial thickness or atrophy have been observed after long term administration of the drug. Conclusions: MF has been demonstrated to be effective in the treatment of the inflammatory diseases of the nose and paranasal sinuses; when compared to its competitors it shows a greater symptom control; it is a reliable treatment in the long term thanks not only to its proven efficacy, but also to its safety being on the market since more than 17 years.

Clinical Efficacy of Tuomin Zhiti Decoction in Allergic Rhinitis

“…Loratadine is widely used for the relief of AR-related symptoms such as sneezing, runny and itchy nose, ocular itching, and burning sensation [16]. Mometasone is a topical glucocorticoid and nasal spray administration exerts local anti-inflammatory effects at doses that do not provoke systemic effects [17]. e combination of loratadine and mometasone furoate has been investigated to be well tolerated and effective in controlling the symptoms of rhinitis [18].…”

Effect of olopatadine-mometasone combination nasal spray on seasonal allergic rhinitis symptoms in an environmental exposure chamber study

“…13,14 The intranasal corticosteroid mometasone effectively reduces SAR symptoms of nasal itching and congestion, sneezing, and rhinorrhea by inhibiting the release of inflammatory mediators and has a well-documented safety profile with minimal systemic effects. [15][16][17][18] The efficacy and safety of US Food and Drug Administration (FDA) −approved olopatadine hydrochloride and mometasone furoate monotherapy nasal sprays have been demonstrated in natural allergen exposure studies 13,14,17,19 and in studies using an environmental exposure chamber (EEC). [20][21][22] The objective of this study was to evaluate the efficacy and safety of once-daily or twice-daily GSP301 treatments vs placebo and 2 FDA-approved nasal sprays, olopatadine 23 and an FDC that contains the antihistamine azelastine hydrochloride and the glucocorticoid fluticasone propionate, 24 in participants with SAR using a ragweed pollen EEC model.…”

Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway

“…Glucocorticoids can be used in three stages (remission induction, intensification (consolidation) and maintenance) of childhood leukemia, but they are best used during remission induction, with the goal of eliminating more than 99% of the diseased tissue (minimal residual disease) [21]. MF is a synthetic glucocorticoid that induces the synthesis of anti-inflammatory factors as well as the role of immunosuppression [16]. It has minimal side effects.…”

“…Mometasone Furoate (MF) is an efficient glucocorticoid for topical treatment of inflammation on the skin, lung and nose [15]. Evidence suggests that the using of MF also improves symptoms associated with adenoid hypertrophy [16]. MF contains hexanediol, which has antimicrobial properties [17].…”