Momordica charantia and Its Novel Polypeptide Regulate Glucose Homeostasis in Mice via Binding to Insulin Receptor

Lo, Hsin-Yi; Ho, Tin-Yun; Lin, Chi‐Tsai; Li, Chia-Cheng; Hsiang, Chien-Yun

doi:10.1021/jf3042402

Cited by 63 publications

(66 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This peptide presents 68 amino acid residues and the insulin receptor binding protein of M. charantia (mcIRBP). It acts by activating insulin receptor signaling pathways and stimulating both the uptake and release of glucose in rat cells [56, 57]. Confirming these data, mcIRBP-19 was observed to be the peptide insulin receptor binding motif of mcIRBP with a similar ability for glucose uptake [58].…”

Section: Discussionmentioning

confidence: 87%

Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and CCK-1r Gene Expression in Obese Wistar Rats

et al. 2018

View full text Add to dashboard Cite

Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest.

show abstract

Section: Discussionmentioning

confidence: 87%

Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and CCK-1r Gene Expression in Obese Wistar Rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…GSK-3 is one of the negative regulators in the hormonal control of glucose homeostasis which are involved in the carbohydrate metabolism through the mechanism of phosphorylation and inactivation of the enzyme glycogen synthase. The novel IR-binding protein (Trypsin inhibitor) was isolated from aqueous extract of M. charantia seeds, which lowered blood sugar levels by regulating the insulin signaling pathway in muscles and adipose tissues and stimulating the IRdownstream pathway [49]. M. charantia extract also considered as an herbal remedy for type-II diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor, responsible for reducing the PPARA gene expression [46].…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

View full text Add to dashboard Cite

Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases. Of late, scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts. The importance of wild edible plants may be traced to antiquity but systemic studies are recent. All the Momordica species have been consumed as vegetable and traditionally used for various disorders. The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system. The active constituents of Momordica plant parts were cucurbitane type triterpenoids, phenolics, glycosides, and several kinds of peptides including Momordica anti-HIV protein (MAP 30). Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf, stem and fruits of Momordica species having several pharmacological activities. There is lack of scientific information available on the wild species which also having several bioactive components with potential activities. So the present review compares and highlights the current knowledge of the nutritional value, phytochemistry and physiological effects of wild species with known variety.

show abstract

“…Previously similar studies using protein extracts from the fruits of Momordica charantia showed insulin secretagogue and insulinomimetic activities in STZ induced diabetic rats [38]. Identification of insulin receptor binding-peptide from Momordica charantia [39] signifies the presence of phytohormones that are capable of regulating insulin signaling pathways.…”

Section: Discussionmentioning

confidence: 94%

Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats

Marella

Maddirela

Badri

et al. 2015

Cell Physiol Biochem

4,313

View full text Add to dashboard Cite

Background: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic “Mcy protein” isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. Materials and Methods: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. Results: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats. Conclusion: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.

show abstract

Momordica charantia and Its Novel Polypeptide Regulate Glucose Homeostasis in Mice via Binding to Insulin Receptor

Cited by 63 publications

References 42 publications

Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and <b><i>CCK-1r</i></b> Gene Expression in Obese Wistar Rats

Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and <b><i>CCK-1r</i></b> Gene Expression in Obese Wistar Rats

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats

Contact Info

Product

Resources

About