Monastrol, a 3,4-dihydropyrimidin-2(1 H )-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α 1 β 2 δ GABA A receptors

Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19

“…Biginelli condensation protocol [27] , [28] , [29] , [30] is a one pot, three components coupling reaction of commercially available starting material thiourea, ethyl acetoacetate and selected aromatic aldehydes namely, o -cyano, o -chloro and o -bromobenzaldehyde in acid medium to afford the corresponding 1,4-dihydropyrimidine esters 4a-c . Hence, saponification of the ethyl ester furnished the sodium salt of the 1,4-dihydropyrimidine analogues followed by acidification of the salts to pH ≈ 4, which provided the acids 5a-c .…”