Monitoring of Heart Ischemia in Blood Serum

Tomečková, Vladimı́ra; Komanický, Vladimír; Kakoush, Mohammad; Krajčíková, Kristína; Glinská, Gabriela; Široká, Monika; Pundová, Lýdia; Samuely, Tomáš; Hložná, Dominika; Lotnyk, Dmytro

doi:10.4236/sar.2016.42002

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…During diseases but also other physiological disturbances of homeostasis, the composition of body fluids (saliva) is changed. These results are reflected in differences on SFS and it is V. Tomečková et al DOI: 10.4236/sar.2017.54004 40 Spectral Analysis Reviewslikely to identify pathological process[17].…”

mentioning

confidence: 99%

The Effect of Different Diet on Saliva

Tomečková¹,

Krajčíková²,

Dolinská³

et al. 2017

SAR

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The aim of this scientific research was to study the influence of various diets (ketogenic, low carb, mixed) on teeth and saliva structure of healthy individuals. The health condition of teeth and the influence of diet (sweets, water intake) were investigated using the questionnaires which were statistically processed by descriptive and inductive statistics. Saliva was examined using synchronous fluorescent fingerprint (SFF) and atomic force microscopy (AFM). The statistical evaluation of answers of respondents using the questionnaires about intake of sweets in their diet showed significant influence of sugars on formation of tooth decay of diet. The intake of water (volume and frequency) did not show significant influence on formation of tooth decay. Endogenous fluorescence and surface structure of saliva differed in healthy subjects with different diet. The most organized surface structure showed low carb diet (without crystals). The least organized surface structure showed ketogenic diet with the big crystals (1-2 μm). Untraditional methods (SFF and AFM) enable the new, sensitive and quick analysis of the mixture of saliva. Saliva of individuals with low carb diet showed the most organized structure. Low content of sugar in diet is important possibility of the prevention before dental carries.

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confidence: 99%

The Effect of Different Diet on Saliva

Tomečková¹,

Krajčíková²,

Dolinská³

et al. 2017

SAR

Self Cite

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“…The increase in porphyrin derivatives indicative of subversion of heme metabolism was consistent with increase in the serum iron at 72 h BDL and can be used as potential intrinsic biomarkers of molecular and cellular changes in cholestasis for early diagnosis (Croce et al, 2011). There is also evidence that SFS can be used to diagnose heart ischemia (Tomečková et al, 2016) and various bowel diseases (Tomečková et al, 2018), but the relevant fluorophores in each of these studies were not identified. It is important to note that autofluorescence measurements cannot be explored as diagnostic tools simply based on their simplicity and label free approach.…”

Section: Applications Of Blood Autofluorescencementioning

confidence: 99%

Autofluorescence of blood and its application in biomedical and clinical research

Shrirao

Schloss

Fritz

et al. 2021

Biotech & Bioengineering

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Autofluorescence of blood has been explored as a label free approach for detection of cell types, as well as for diagnosis and detection of infection, cancer, and other diseases.Although blood autofluorescence is used to indicate the presence of several physiological abnormalities with high sensitivity, it often lacks disease specificity due to use of a limited number of fluorophores in the detection of several abnormal conditions. In addition, the measurement of autofluorescence is sensitive to the type of sample, sample preparation, and spectroscopy method used for the measurement. Therefore, while current blood autofluorescence detection approaches may not be suitable for primary clinical diagnosis, it certainly has tremendous potential in developing methods for large scale screening that can identify high risk groups for further diagnosis using highly specific diagnostic tests. This review discusses the source of blood autofluorescence, the role of spectroscopy methods, and various applications that have used autofluorescence of blood, to explore the potential of blood autofluorescence in biomedical research and clinical applications.

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“…These methods include uorescence spectroscopy (FS) which has been validated as a diagnostic tool during various pathologies, e.g. diastolic dysfunction, 16 non-small-cell lung carcinoma, 17 ischemic heart disease, 18 diabetes mellitus 19 and many others. The method is based on the analysis of the autouorescent substances occurring in the sample (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…In spite of the fact that it is mostly used for in vitro studies, such as for differentiating between normal and cancerous cells [24][25][26] or detection of viruses, 27 it is also used for novel studies and diagnostics. Examples of such studies include the detection of signicant differences between the blood serum of patients and healthy controls, which were observed during ischemic heart disease 18 and breast cancer 28 , together with assessment of changes in the dermis. 29 In our pilot study we assessed the diagnostic potential of FS, IRS and AFM for diabetes mellitus using tear uid.…”

Section: Introductionmentioning

confidence: 99%