Monoclonal Antibody for Avian Thymic Hormone

Hall, C.A.; Beach, G.G.; Ragland, W.L.

doi:10.1089/hyb.1991.10.575

Cited by 10 publications

(11 citation statements)

References 6 publications

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“…In post-hatched chickens, these cells contain numerous electron-light and electron-dense cytoplasmic vesicles (Frazier 1973;Kendall 1980), whose number was related to progressive cell maturation during ontogeny (Sugimoto et al 1977). The observation that cortical RECs establish close relationships with thymocytes (Kendall 1980(Kendall , 1991, and contain hormones such as the avian thymic hormone/parvalbumin (Hall et al 1991;Kiraly and Cello 1993) that could promote thymocyte differentiation (Barger et al 1991;Hall et al 1991;Murthy and Ragland 1992), highlighted the functional correlation between these cell types.…”

Section: Cortical Reticular Epithelial Cellsmentioning

confidence: 99%

Influence of partial decerebration and hypophyseal allograft on differentiation of thymic epithelial cells in chick embryos: an ultrastructural study

et al. 1996

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The thymus of 18-day-old normal-chick embryos, partially decerebrated chick embryos, and partially decerebrated embryos bearing hypophyseal allografts were analysed by light and transmission electron microscopy. The hypophyseal influence on the cytological differentiation of epithelial components has been studied. The thymus of partially decerebrated embryos showed a delayed differentiation of some types of epithelial cells and a marked decrease in number of lymphoid cells. Partially decerebrated embryos with hypophyseal implants showed a consistent recovery in the degree of differentiation of epithelial components. These findings indicate the influence of the hypophysis in establishing a correct environment for stromal cell differentiation.

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Section: Cortical Reticular Epithelial Cellsmentioning

confidence: 99%

Influence of partial decerebration and hypophyseal allograft on differentiation of thymic epithelial cells in chick embryos: an ultrastructural study

et al. 1996

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“…For more than a decade Ragland and his coworkers (Barger et al 1977;Murthy and Ragland 1984) have studied a protein isolated from chicken thymus, called Avian Thymic Hormone (ATH), and have found that it promotes the development of T-lymphocytes (Murthy et al 1984a, b). It has been reported that the nucleic acid sequence of ATH (Brewer et al 1989;Henzl 1990, 1991a, b;Henzl et al 1991 ;Serda and Henzl 1991) is nearly the same as that of parvalbumin (PV) from chicken, turtle and amphibian muscle (Strehler et al 1977;Heizmann and Strehler 1979;Hall et al 1991). Since PV is found intracellularly in muscles (P6ch~re et al 1973;Celio and Heizmann 1982) and brain (Celio and Correspondence to: M.R.…”

Section: Introductionmentioning

confidence: 99%

Parvalbumin and calretinin in the avian thymus

Király

Celio

1993

Anat Embryol

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The avian thymic hormone, known to support the maturation of T-lymphocytes, is biochemically similar to parvalbumin. However, its exact cellular distribution in the thymus is unknown. We have therefore studied the occurrence of parvalbumin and other related calcium-binding proteins in this organ by immunohistochemistry during development and after hatching. Parvalbumin immunoreactivity appears in the epithelial cells on embryonic day 9, and is expressed in the cortical reticular cells in the adult. Calretinin is found in the clusters of medullary epithelial cells from embryonic day 11, whereas calbindin D-28k is absent from this organ. Thus, calcium binding-proteins are excellent markers for different compartments of the avian thymus in embryonic life and after hatching, and their expression seems to coincide with their functional maturation.

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“…Human tissue was employed in the present study mainly because (1) the information obtained from animal studies cannot be always extrapolated to humans and (2) some developmentally transient structures of the human cortex may be structurally different or even absent in animals Sidman and Rakic, 1982;Spreafico et al, 1999). For example, the expression of some calcium binding proteins in humans has been found to be different from those in rodents and chickens (Hall et al, 1991;Heizmann et al, 1982;Huber et al, 1990;Murthy et al, 1984). In the present study, three antibodies against S100A4, S100A5, and S100A13 have been used to immunohistochemically localize the proteins on the brain sections.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of S100 proteins in the developing human hippocampus and temporal cortex

Chan

Xia

Dacui³

et al. 2003

Microscopy Res & Technique

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S100 calcium binding proteins have long been known to express in the adult nervous system, but their distribution in the developing brain, especially the human fetal brain, is largely unknown. We used an immunohistochemical method to determine the expression of three S100 proteins, namely S100A4, S100A5, and S100A13, in the human fetal hippocampus and temporal cortex from 12 to 33 weeks of gestation. At 12 weeks, S100A5 was strongly expressed in the cells and fibers of the polymorphic, pyramidal, and molecular layers of the hippocampus. Thereafter, its expression decreased with age. In the temporal cortex, S100A5 expression was detected from 12 weeks onwards, peaked at 20 to 24 weeks, and then decreased with age. The horizontal fibers of the marginal zone were immunoreactive at all stages examined. S100A13 immunoreactivity was also detected in both cells and fibers of the hippocampus at 12 weeks, became slightly stronger at 20 weeks, and then decreased with age. In the temporal cortex, S100A13 immunoreactivity was also strong in all cellular layers at 12 to 24 weeks before it declined with age from 28 weeks onwards. Among the three proteins examined, S100A4 showed the weakest expression, which was detected in the cells and fibers of the hippocampus and the temporal cortex at all stages examined. Our results have demonstrated for the first time, in the human fetal hippocampus and temporal cortex, specific spatio-temporal patterns of expression of these proteins, all of which are likely to have different roles to play during development despite their pronounced sequence homology.

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Monoclonal Antibody for Avian Thymic Hormone

Cited by 10 publications

References 6 publications

Influence of partial decerebration and hypophyseal allograft on differentiation of thymic epithelial cells in chick embryos: an ultrastructural study

Influence of partial decerebration and hypophyseal allograft on differentiation of thymic epithelial cells in chick embryos: an ultrastructural study

Parvalbumin and calretinin in the avian thymus

Differential expression of S100 proteins in the developing human hippocampus and temporal cortex

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