Monocyte Count-To-High-Density Lipoprotein-Cholesterol Ratio is Associated with Abdominal Aortic Aneurysm Size

Cagli, Kumral; Tok, Derya; Turak, Osman; Günertem, Eren; Yayla, Çağrı; Lafçı, Gökhan; Ulaş, Murat; Çağlı, Kerim

doi:10.2217/bmm-2016-0157

Cited by 21 publications

(19 citation statements)

References 43 publications

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“…Recognised as a recently-emerged inflammation-based marker, the monocyte count to HDL-C ratio (MHR) has been reported to be a new predictor and prognostic indicator of mortality and morbidity in many diseases [ 12 , 13 ]. The MHR has also been found to be correlated with hsCRP levels in diseases that are associated with chronic inflammation, such as cardiovascular disease [ 14 ], chronic kidney disease [ 12 ], abdominal aortic aneurysm [ 15 ], intracerebral hemorrhage [ 16 ], hypertension [ 17 ], and metabolic syndromes [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome

Usta

Avcı

Bülbül

et al. 2018

Reprod Biol Endocrinol

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BackgroundWomen with polycystic ovary syndrome are more likely to suffer from obesity, insulin resistance, and chronic low-grade inflammation. In fact, the excessive activation of monocytes exacerbates oxidative stress and inflammation. However, high-density lipoprotein cholesterol neutralizes the pro-inflammatory and pro-oxidant effects of monocytes. The aim of this study is to investigate whether monocyte counts to high-density lipoprotein cholesterol ratio can predict the inflammatory condition in patients with polycystic ovary syndrome.MethodsIn this cross-sectional study, a total of 124 women (61 of them with polycystic ovary syndrome and 63 age-matched healthy volunteers) were included in the study population. Obese polycystic ovary syndrome patients (n = 30) with a body mass index of ≥25 kg/m2 and lean polycystic ovary syndrome patients (n = 31) with a body mass index of < 25 kg/m2 were compared to age-and body mass index-matched healthy subjects (30 obese and 33 non-obese).ResultsThe monocyte counts to high density lipoprotein cholesterol values in women with polycystic ovary syndrome were significantly higher than in control subjects (p = 0.0018). Moreover, a regression analysis revealed that body mass index, the homeostasis model assessment of insulin resistance and the high sensitivity C-reactive protein levels were confounding factors that affected the monocyte counts to high density lipoprotein cholesterol values. Additionally, a univariate and multivariate logistic regression analysis demonstrated that the increased monocyte counts to high density lipoprotein cholesterol values were more sensitive than the other known risk factors (such as increased body mass index, homeostasis model assessment of insulin resistance and high sensitive C-reactive protein levels) in the prediction of the inflammation in patients with polycystic ovary syndrome.ConclusionThe present study demonstrated that the monocyte count to high density lipoprotein cholesterol may be a novel and useful predictor of the presence of polycystic ovary syndrome.

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Section: Introductionmentioning

confidence: 99%

The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome

Usta

Avcı

Bülbül

et al. 2018

Reprod Biol Endocrinol

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“…In asymptomatic abdominal aortic aneurysm, a focal atherosclerotic disease, high MHR values significantly correlated with the maximum diameter of the abdominal aorta (r = 0.366) and suggested that MHR was independently associated with aneurysm size (Cagli et al, 2016) (Korkmaz et al, 2017).…”

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confidence: 99%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

219

188

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Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

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“…Moreover, it has been shown to be a new potential marker for predicting abdominal aortic aneurysm (AAA) size in asymptomatic patients. Çağlı et al showed that MHR was independently associated with the AAA size after dividing 120 asymptomatic AAA patients into two groups according to the MHR median value (54.3 ± 10.6 mm vs 62.0 ± 12.4 mm, P < 0.001, respectively) [26].…”

Section: Discussionmentioning

confidence: 99%

Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid aortic valve degeneration

Karaduman¹,

Ayhan²,

Keleş³

et al. 2020

Turk J Med Sci

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Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve (BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to highdensity lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and pathophysiology of BAV stenosis. Materials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were retrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected retrospectively from the patients' records. MHR was measured as the ratio of the absolute monocyte count to the HDL-C value. Results: Seventy BAV (mean age: 72.0 ± 9.1 years, 42.9% female) and 140 TAV patients (mean age: 77.9 ± 8.3 years, 51.4% female) with severe aortic stenosis were enrolled in this study. There was no difference between the two groups in terms of another baseline demographic or clinic findings except age (P < 0.001). Monocyte count, hemoglobin level, mean platelet volume was significantly higher, and HDL-C level was significantly lower in the BAV group, while other lipid and CBC parameters were found to be similar. In the multivariate analysis, MHR (P = 0.005, 95% CI: 0.90-0.98) and, as expected, age (P = 0.001, 95% CI: 1.02-1.11) were found to be significant as the independent predictor of BAV, after adjusting for other risk factors. Conclusion: Our study showed a significant correlation between increased MHR and BAV. MHR was determined as a significant independent predictor for the speed of progression and diagnosis of severe BAV stenosis in multivariate analysis.

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Monocyte Count-To-High-Density Lipoprotein-Cholesterol Ratio is Associated with Abdominal Aortic Aneurysm Size

Abstract: Monocyte/HDL ratio is independently associated with AAA size.

Cited by 21 publications

References 43 publications

The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome

The monocyte counts to HDL cholesterol ratio in obese and lean patients with polycystic ovary syndrome

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid aortic valve degeneration

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