Monocyte function associated with intermittent lentinan therapy after resection of gastric cancer

Takeshita, Kazuyoshi; Hayashi, Shigeya; Tani, Masaji; Kando, Fumio; Saito, Naoyasu; Endo, M

doi:10.1016/s0960-7404(96)80018-1

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Human Monocytes/Macrophages in vivo. Thirty-three gastric cancer patients, in various stages of the disease, participated in a study on the effects of lentinan at least 6 months after they had undergone gastrectomy (48). Although the most commonly used dosage regime for lentinan is 2 mg once a week, these patients received 2 mg of lentinan iv either at 2-or 4-week intervals.…”

Section: The Effects Of Lentinan Grn Spg and Ssg On Different Cellmentioning

confidence: 99%

“…The production of cytokines, such as TNF-␣ and IL-1␤, is another macrophage response to zymosan binding to the ␤-glucan receptor (96). The induction of these cytokines from mouse and human macrophages has been reported for lentinan (28,31,48), GRN (32,33,47), and SSG, though only in vivo (37,94). Furthermore, zymosan-binding to the ␤-glucan receptor induces the release of reactive oxygen species such as superoxide anion and H 2 O 2 .…”

Section: Strain Differences Genetic Factors Other Possible Explanatmentioning

confidence: 99%

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Mushrooms, Tumors, and Immunity

Borchers¹,

Stern²,

Hackman³

et al. 1999

Experimental Biology and Medicine

287

197

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Medicinal properties have been attributed to mushrooms for thousands of years. Mushroom extracts are widely sold as nutritional supplements and touted as beneficial for health. Yet, there has not been a critical review attempting to integrate their nutraceutical potential with basic science. Relatively few studies are available on the biologic effects of mushroom consumption, and those have been performed exclusively in murine models. In this paper, we review existing data on the mechanism of whole mushrooms and isolated mushroom compounds, in particular (1→3)-␤-Dglucans, and the means by which they modulate the immune system and potentially exert tumor-inhibitory effects. We believe that the antitumor mechanisms of several species of whole mushrooms as well as of polysaccharides isolated from Lentinus edodes, Schizophyllum commune, Grifola frondosa, and Sclerotinia sclerotiorum are mediated largely by T cells and macrophages. Despite the structural and functional similarities of these glucans, they differ in their effectiveness against specific tumors and in their ability to elicit various cellular responses, particularly cytokine expression and production. Unfortunately, our data base on the involvement of these important mediators is still rather limited, as are studies concerning the molecular mechanisms of the interactions of glucans with their target cells. As long as it remains unclear what receptors are involved in, and what downstream events are triggered by, the binding of these glucans to their target cells, it will be difficult to make further progress in understanding not only their antitumor mechanisms but also their other biological activities.

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Section: The Effects Of Lentinan Grn Spg and Ssg On Different Cellmentioning

confidence: 99%

Section: Strain Differences Genetic Factors Other Possible Explanatmentioning

confidence: 99%

Mushrooms, Tumors, and Immunity

Borchers¹,

Stern²,

Hackman³

et al. 1999

Experimental Biology and Medicine

287

197

View full text Add to dashboard Cite

show abstract

“…Evaluations conducted with macrofungi confirmed the effectiveness of the extracts of the fruiting bodies and mycelia in the inhibition of various cancer cell lines [2] [23]- [25]. The immunomodulatory effects of the mushrooms are well described in the literature and are related to the increased function of monocytes in the production of Interleukin-1 [11] [26] and expression of cytokines. Molecules like glucans are relatively resistant to the stomach acid and are trapped by macrophage receptors present on the intestinal wall as the dectin-1, the toll-like receptor 2 (a class of proteins that play a role in immune system) and lactosylceramides The β-glucans with its various structures have different affinities for these receptors to elicit different host responses [16].…”

Section: Immunomodulation and Anti-tumour Effects Of L Edodesmentioning

confidence: 90%

A Review on General Nutritional Compounds and Pharmacological Properties of the <i>Lentinula edodes</i> Mushroom

Finimundy¹,

Dillon²,

Henriques³

et al. 2014

FNS

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Lentinula edodes is a macrofungus with great potential for therapeutic applications and serves as a model for investigating functional fungi properties and isolating pure compounds for pharmaceutical use. Mushrooms have a great nutritional value and present medicinal molecules including polysaccharides, terpenoids, sterols and lipids, that participate actively in several human disorders and modulate mechanisms involved in the immune system regulation. This review will focus on general nutritional compounds and pharmacological properties of L. edodes.

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“…It also facilitates the synthesis of IgG and IgM by B cells, improves the levels of IgA, C3 and the ratio of CD4 ' /CD8 ' (Suzuki et al, 1994;Zhang et al, 2003). It has been demonstrated that levels of IL-1 and TNF-a are increased in both mouse and human macrophages upon treatment with LNT, subsequently augmenting T-cell response to IL-2 and activating LAK and NK cells (Fruehauf et al, 1982;Takeshita et al, 1996). The research indicates (Suzuki et al, 1994) that LNT can up-regulate the level of IL-2 and IL-12, down-regulate the level of IL-4 and stimulate Th1 cell multiplication, increase IL-1, IL-3, CSF, TNF and IFN, up-regulate cell-mediated immune response, to assist in clearing the cell of viral infection.…”

Section: Discussionmentioning

confidence: 99%

Regulation of β-defensin-2 gene expression by lentinan in human pulmonary epithelial cells

Zhao

Dong

Teng

et al. 2009

Food and Agricultural Immunology

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Human b-defensin-2 (HBD-2) is considered a crucial endogenous antimicrobial peptide, performing this role with both a broad spectrum and high performance. To investigate the regulation of b-defensin-2 gene expression by lentinan (LNT) and the relationship possessed other than a dose or time dependence. We cultured pulmonary glandular epithelial cells line (SPC-A-1) in vitro. Following treatment with LNT at different concentration (0, 12.5, 25, 50, 100 and 200 mg/ml) and time (1st, 2nd, 4th, 8th, 16th, 24th and 48th h). Utilising the reverse transcription polymerase chain reaction (RT-PCR) with primer designed for HBD-2, the total RNA was extracted from SPC-A-1 cells and the RT-PCR was performed with primers for HBD-2. The expression of HBD-2 mRNA treated by varying concentration of LNT was significantly higher than those from blank control groups (PB0.05) in vitro. In addition, the expression of HBD-2 mRNA in the treatment group with a LNT concentration of 100 mg/ml at the time of 8th h was significantly higher (PB0.05) in vitro, demonstrating both a concentration and time dependence. For the first time in vitro, we demonstrated that LNT can induce b-defensin-2 mRNA expression and that the amount of induced expression has both the dose and time-dependent relationship with LNT.

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Monocyte function associated with intermittent lentinan therapy after resection of gastric cancer

Cited by 11 publications

References 7 publications

Mushrooms, Tumors, and Immunity

Mushrooms, Tumors, and Immunity

A Review on General Nutritional Compounds and Pharmacological Properties of the <i>Lentinula edodes</i> Mushroom

Regulation of β-defensin-2 gene expression by lentinan in human pulmonary epithelial cells

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Monocyte function associated with intermittent lentinan therapy after resection of gastric cancer

Cited by 11 publications

References 7 publications

Mushrooms, Tumors, and Immunity

Mushrooms, Tumors, and Immunity

A Review on General Nutritional Compounds and Pharmacological Properties of the &lt;i&gt;Lentinula edodes&lt;/i&gt; Mushroom

Regulation of β-defensin-2 gene expression by lentinan in human pulmonary epithelial cells

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A Review on General Nutritional Compounds and Pharmacological Properties of the <i>Lentinula edodes</i> Mushroom