Monodisperse, Temperature‐Sensitive Microgels Crosslinked by SiOSi Bonds

Zhang, Jiantao; Pan, Changjiang; Keller, Thomas F.; Bhat, Rahila; Gottschaldt, Michael; Schubert, Ulrich S.

doi:10.1002/mame.200900038

Cited by 11 publications

(9 citation statements)

References 44 publications

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“…The chemical features for thermoresponsive hydrogels can still be measured by conventional means like FTIR, NMR and XPS [86][87][88], but there are several physical characteristics that require special measurements.…”

Section: Characterization Of Thermoresponsive Hydrogelsmentioning

confidence: 99%

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

et al. 2020

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Poly(N-isopropylacrylamide) (PNIPAAm) is a typical thermoresponsive polymer used widely and studied deeply in smart materials, which is attractive and valuable owing to its reversible and remote "on-off" behavior adjusted by temperature variation. PNIPAAm usually exhibits opposite solubility or wettability across lower critical solution temperature (LCST), and it is readily functionalized making it available in extensive applications. Cell culture is one of the most prospective and representative applications. Active attachment and spontaneous detachment of targeted cells are easily tunable by surface wettability changes and volume phase transitions of PNIPAAm modified substrates with respect to ambient temperature. The thermoresponsive culture platforms and matching thermal-liftoff method can effectively substitute for the traditional cell harvesting ways like enzymatic hydrolysis and mechanical scraping, and will improve the stable and high quality of recovered cells. Therefore, the establishment and detection on PNIPAAm based culture systems are of particular importance. This review covers the important developments and recommendations for future work of the preparation and characterization of temperature-responsive substrates based on PNIPAAm and analogues for cell culture applications.

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Section: Characterization Of Thermoresponsive Hydrogelsmentioning

confidence: 99%

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

et al. 2020

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“…Jandt et al have fabricated temperature-sensitive poly(N-isopropylacrylamide) microgels based on the hydrolysis/condensation of siloxane groups by free radical precipitation. 98,99 The thermal initiator, ammonium persulfate (APS), was used to initiate the radical copolymerization of NIPAAm, as well as to catalyze the hydrolysis/condensation of siloxane groups due to the acidic environment caused by APS. This method has not yet been used for biomedical gel synthesis.…”

Section: Strain-promoted Azide-alkyne Cycloaddition (Spaac)mentioning

confidence: 99%

Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications

et al. 2015

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Micro- or nanosized three-dimensional crosslinked polymeric networks have been designed and described for various biomedical applications, including living cell encapsulation, tissue engineering, and stimuli responsive controlled delivery of bioactive molecules. For most of these applications, it is necessary to disintegrate the artificial scaffold into nontoxic residues with smaller dimensions to ensure renal clearance for better biocompatibility of the functional materials. This can be achieved by introducing stimuli-cleavable linkages into the scaffold structures. pH, enzyme, and redox potential are the most frequently used biological stimuli. Moreover, some external stimuli, for example light and additives, are also used to trigger the disintegration of the carriers or their assembly. In this review, we highlight the recent progress in various chemical and physical methods for synthesizing and crosslinking micro- and nanogels, as well as their development for incorporation of cleavable linkages into the network of micro- and nanogels.

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“…18 Jandt et al used a siloxane coupling agent 3-methacryloxypropyltrimethoxysilane (MPTMS) as the crosslinker for the synthesis of PNIPAAm microgels. 19,20 Polysiloxanes were rarely used as crosslinkers for the synthesis of microgels due to their low water solubility.…”

Section: Introductionmentioning

confidence: 99%

Degradable microgels synthesized using reactive polyvinylalkoxysiloxanes as crosslinkers

et al. 2013

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In the present work we demonstrate the synthesis of degradable thermo-sensitive poly(N-vinylcaprolactam) microgels via precipitation polymerization using reactive polyvinylalkoxysiloxanes as crosslinkers (Cross-PAOS). These compounds were synthesized by co-condensation of vinyltriethoxysilane and tetraethoxysilane followed by transesterification with poly(ethylene glycol) monomethyl ether (PEG) to increase their water solubility. Experimental results showed that the microgels synthesized using Cross-PAOS exhibited excellent colloidal stability in water. These microgels are thermo-responsive and their size can be tuned depending upon the ratio of vinyl and PEG groups in Cross-PAOS. The size of microgel particles increases with increasing vinyl groups in Cross-PAOS while it decreases with increasing PEG groups. The presence of silicon dioxide in the microgel structure was confirmed by X-ray photoelectron spectroscopy and elemental analysis. Additionally, the microgels prepared in this way contain crosslinking sites which can be degraded under alkaline conditions.

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Monodisperse, Temperature‐Sensitive Microgels Crosslinked by SiOSi Bonds

Cited by 11 publications

References 44 publications

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

Preparation and Characterization of Thermoresponsive Poly(N-Isopropylacrylamide) for Cell Culture Applications

Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications

Degradable microgels synthesized using reactive polyvinylalkoxysiloxanes as crosslinkers

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