Monoolein: a magic lipid?

Kulkarni, Chandrashekhar V.; Wachter, Wolfgang; Iglesias, Guillermo R.; Engelskirchen, Sandra; Ahualli, Silvia

doi:10.1039/c0cp01539c

Cited by 401 publications

(436 citation statements)

References 204 publications

(264 reference statements)

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“…As well as temperature-water content phase diagrams 10 , pressure-temperature (p-T) studies on the MO-water system have also been carried out [26][27][28][29] . In the excess water region the Pn3m cubic phase was commonly observed, which converts into a lamellar phase beyond pressures of about 2 kbar at 20 C 27 .…”

Section: Compression and Decompression Of The Lipid-membrane Protein mentioning

confidence: 99%

“…It doesn't denature until very high pressures in the region of 26 kbar, and also does not show significant conformational transitions below 3.7 kbar, making it suitable for the current studies (performed only up to 2.6 kbar) 23 . Monoolein (MO) was used as a membrane forming lipid component which is a derivative of 18-C mono-unsaturated fatty acid 10 . The proportion of the latter lipid chain type was found to increase when the culture pressure was increased in case of growth studies of genetically tractable deep-sea bacterium…”

Section: Figurementioning

confidence: 99%

“…In recent years, lipid based nanostructures are increasingly used as model membranes [9][10] to study various biological processes for example, membrane fusion [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

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Pressure effects on a protein–lipid model membrane

et al. 2013

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We attempt to mimic cellular biomembrane structures using a mixture of two important biochemical components -a membrane protein and a lipid, in presence of water. Protein loaded lipid structures were subjected to a wide range of pressures to examine their morphological reorganizations using synchrotron X-ray radiations under stepwise pressure variation and rapid pressure jumps. Here we report the first evidence of a highly swollen gyroid cubic phase under high pressure (gyroid type structures have been seen in ER and Golgi membranes) and the close resemblance of lipid nanostructural behavior with literature studies on compression-decompression of piezophilic biomembranes. These studies are promising for understanding complex

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Section: Compression and Decompression Of The Lipid-membrane Protein mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Pressure effects on a protein–lipid model membrane

et al. 2013

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“…10,13,[16][17][18][19][20] The type of self-assembled nanostructure, also called liquid crystalline lipid phases interacting with carbon nanotubes could differ from lipid to lipid 21 as well as with physicochemical conditions. 22 Usually the lamellar nanostructure ( Fig. 1) is most commonly observed which mimics plasma membrane whereas hexagonal and cubic types of nanostructures resemble complex intracellular biomembranes.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotubes for stabilization of nanostructured lipid particles

et al. 2015

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Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they are combined with essential biological materials like lipids. Lipids have been used earlier for enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application of CNTs for stabilization of internally self-assembled nanostructured lipid particles of 2-5 μm size. Single-walled ( pristine) as well as -OH and -COOH functionalized multi-walled CNTs were employed to produce nanostructured emulsions which stayed stable for months and could be re-dispersed after complete dehydration. Concentrations of CNTs employed for stabilization were very low; moreover CNTs were well-decorated with lipid molecules. These features contribute towards reducing their toxicity and improving biocompatibility for biomedical and pharmaceutical applications. Our approach paves the way for future development of combination therapies employing both CNTs and nanostructured lipid self-assembly together as carriers of different drugs.

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“…In this work we have taken a different approach and exploited dispersions of a lipid that forms non-lamellar selfassemblies. The main motivation behind this was twofold, 1) lyotropic liquid crystalline selfassemblies of non-lamellar (hexagonal and cubic) types, are highly attractive for biotechnological applications [15,16], hence studying their interaction with fullerenes may outline the possibilities of developing novel hybrid nanomaterials similar to carbon nanotube-lipid hybrids we developed recently [17][18][19], and 2) due to their unique structure fullerenes could act as stabilizers for nanostructured lipid emulsions, by which an elegant properties of both -fullerenes and lipid nanostructures could be utilized for novel applications.…”

Section: Introductionmentioning

confidence: 99%

Effect of fullerene on the dispersibility of nanostructured lipid particles and encapsulation in sterically stabilized emulsions

Kulkarni

Moinuddin

Agarwal

2016

Journal of Colloid and Interface Science

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Abstract:We report on the effect of fullerenes (C60) on the stability of nanostructured lipid emulsions. These (oil-in-water) emulsions are essentially aqueous dispersions of lipid particles exhibiting self-assembled nanostructures at their cores. The majority of previous studies on fullerenes were focused on planar and spherical lipid bilayer systems including pure lipids and liposomes. In this work, fullerenes were interacted with a lipid that forms nanostructured dispersions of nonlamellar self-assemblies. A range of parameters including the composition of emulsions and sonication parameters were examined to determine the influence of fullerenes on in-situ and prestabilized lipid emulsions. We found that fullerenes mutually stabilize very low concentrations of lipid molecules, while other concentration emulsions struggle to stay stable or even to form at first instance; we provide hypotheses to support these observations. Interestingly though, we were able to encapsulate varying amounts of fullerenes in sterically stabilized emulsions. This step has a significant positive impact, as we could effectively control an inherent aggregation tendency of fullerenes in aqueous environments. These novel hybrid nanomaterials may open a range of avenues for biotechnological and biomedical applications exploiting properties of both lipid and fullerene nanostructures.

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Monoolein: a magic lipid?

Cited by 401 publications

References 204 publications

Pressure effects on a protein–lipid model membrane

Pressure effects on a protein–lipid model membrane

Carbon nanotubes for stabilization of nanostructured lipid particles

Effect of fullerene on the dispersibility of nanostructured lipid particles and encapsulation in sterically stabilized emulsions

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