Montmorillonite intercalated with vitamin B1 as drug carrier

Joshi, Ghanshyam V.; Patel, Hasmukh A.; Kevadiya, Bhavesh D.; Bajaj, Hari C.

doi:10.1016/j.clay.2009.06.001

Cited by 166 publications

(88 citation statements)

References 24 publications

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“…The background of this considering the conditions of cation exchange [1][2][3] has not been understood yet. However, our present experimental study would suggest the possibility of such a phenomenon.…”

Section: Resultsmentioning

confidence: 99%

“…The intercalation of drugs into the interlayer space of clay minerals is one of the possible ways for drug delivery [1][2][3]. The occurrence of rare earths in several products can improve their applicability due to advantageous properties of lanthanoides like unique electron con-figuration, fluorescence, high refractive index, high magnetic anisotropy, high electrical conductivity and high oxygen storage and release capacity.…”

Section: Introductionmentioning

confidence: 99%

“…The distant future goal is to elaborate more efficient drug delivery by the help of montmorillonite intercalated drugs. In previous works [1][2][3] montmorillonites, having mainly Na ions in the in the interlayer space, have been used to deliver e.g. ibuprofen, vitamin B 1 and antibacterial agents.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic sublattices in Np2Co17 and Np2Ni17

et al. 2016

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Novel montmorillonites were prepared by the exchange of the interlayer cations with a series of rare earth cations (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, and Er) and characterized by XRD, XRF, SEM, chemical analysis and 57 Fe Mössbauer spectroscopy. An unexpected magnetically split component, assigned to iron being in the interlayer space, was observed in the Mössbauer spectra at 78K in some rare earth cation exchanged montmorillonite. This paper is the initial report about this observation. The transition of iron from the octahedral site to the interlayer and possible incorporation of rare earths in sites different from those which are in the interlayer space was concluded.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnetic sublattices in Np2Co17 and Np2Ni17

et al. 2016

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“…The mixture was stirred at optimum pH for 24 h. The residue of this mixture was then collected by filtration and heated at 105 °C for 6 h. The as-synthesized drug delivery system (denoted MMT2) was analyzed by FTIR spectrometer and X-ray diffractometer. The amount of metformin HCl encapsulated on activated montmorillonitewas calculated using UV-visible spectrophotometric method [15]. In vitro drug release evaluation was conducted by mixing 1 g of MMT2 with 100 mL of simulated gastric solution (buffer pH 1.2).…”

Section: Methodsmentioning

confidence: 99%

in vitro Controlled Drug Release of Antidiabetic Metformin HCl from Citric Acid Activated Natural Montmorillonite

Putra¹,

Sitanggang²,

Suarya³

et al. 2017

Asian J. Chem.

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In this work, metformin HCl was encapsulated on citric acid activated montmorillonite as drug delivery system. The as-synthetized drug delivery systems were characterized by using FTIR and X-ray diffraction. FTIR spectra showed the presence of bending vibration of N-H from primary amines group and streching vibration of C=N at 1635.64 and 1506.41 cm -1 , respectively. X-ray diffraction pattern also showed a widening of the diffraction peaks of montmorillonite after encapsulated by metformin HCl. In vitro drug release results showed that the release of metformin HCl from the drug delivery system in simulated intestinal fluid (pH 7.4) higher than that in simulatied gastric fluid (pH 1.2) with a value of drug release of 61.44 % and 39.41 %. Metformin HCl release kinetics at each pH follow the zero-order model (pH 1.2 with R = 0.9924; pH 7.4 with R = 0.9972) suggested diffusion-controlled release mechanism.

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“…Drugs were intercalated by ion exchange into the interlayer space of swelling clay minerals, particularly montmorillonite [15][16][17] and of layered double hydroxides [17]. However, the guest drugs adapted to this technique are usually limited to ionic drug molecules, such as vitamin B 1 [18], buformin hydrochloride [19], and ibuprofen sodium salt [20,21]. The interlayer space of the montmorillonite is approximately 0.3-0.5 nm and reaches up to approximately 4.5 nm in organoclays [22].…”

Section: Introductionmentioning

confidence: 99%