Morbidity and Mortality of Infants With Very Low Birth Weight in Japan: Center Variation

Kusuda, Satoshi; Fujimura, Masanori; Sakuma, Izumi; Aotani, Hirofumi; Kabe, Kazuhiko; Itani, Yoshio; Ichiba, Hiroyuki; Matsunami, Katsura; Nishida, Hiroshi

doi:10.1542/peds.2005-2724

Cited by 225 publications

(212 citation statements)

References 15 publications

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“…The higher incidence of severe intraventricular hemorrhage observed in the <34 weeks GA compared with the ≥34 weeks GA group was also an expected observation, given that babies born at an earlier GA are known to be at increased risk for severe intraventricular hemorrhage [24,25]. This finding was also consistent with findings from a larger Japanese observational study conducted by Kusuda and colleagues [26], which showed that in the 2145 very low birthweight infants studied (mean [SD] birthweight, 1024 [302] g; mean [SD] GA, 28.9 [3.4] weeks), the observed incidence of grade 3 or 4 intraventricular hemorrhage was 7%. In prospective, controlled studies of iNO conducted in premature neonatal populations with respiratory failure in the United States, the overall safety profile observed (including reported incidences of intraventricular hemorrhage) has been similar in the iNO treatment arms compared with patient groups who received placebo or no iNO [27][28][29][30][31][32].…”

Section: Discussionsupporting

confidence: 85%

Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience

Suzuki

Togari

Potenziano

et al. 2018

Journal of Perinatal Medicine

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Objective: To analyze data from a registry of Japanese neonates with hypoxic respiratory failure associated with pulmonary hypertension (PH) to compare the effectiveness of inhaled nitric oxide (iNO) in neonates born <34 weeks vs. ≥34 weeks gestational age (GA). Materials and methods: iNO was administered according to approved Japanese product labeling. Study data were collected before iNO administration and at predefined intervals until discontinuation. Results: A total of 1,114 neonates were included (n = 431, <34 weeks GA; n = 675, ≥34 weeks GA; n = 8, missing age data). Mean decrease from baseline oxygenation index (OI) was similar in both age groups. OI reduction was more pronounced in the <34 weeks subgroups with baseline OI ≥25. Survival rates were similar in the <34 weeks GA and ≥34 weeks GA groups stratified by baseline OI (OI < 15, 89% vs. 93%; 15 ≤ OI < 25, 85% vs. 91%; 25 ≤ OI ≤ 40, 73% vs. 79%; OI > 40, 64% vs. 66%). Conclusion: iNO improved oxygenation in preterm neonates as effectively as in late preterm and term neonates, without negative impact on survival. If clinically significant PH is present, as measured by pulse oximetry or echocardiography, a therapeutic trial of iNO might be indicated for preterm neonates.

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Section: Discussionsupporting

confidence: 85%

Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience

Suzuki

Togari

Potenziano

et al. 2018

Journal of Perinatal Medicine

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“…Nuestras cifras también son parecidas a las de un estudio de tendencias de mortalidad y morbilidad en RNMBPN en América del Norte en el período 1990 y 1991, que muestra un cambio respecto a la intervención prenatal con el uso de corticoides con un incremento de uso del 23,8% en 1991 a 71,6% en 1999 (12). Otro estudio en Japón, con 2.145 RNMBPN, describe un 41% de su uso, con un amplio rango de variación en los 37 centros evaluados (13). Por último, y realmente notable es la información del reporte clínico anual del 2005 del informe del Nacional Women´s Hospital en Auckland Nueva Zelanda donde se comunica que el 94% de los RN menores de 32 semanas de gestación recibió corticoides antenatales, y un 88% en el periodo 1995-2003 (14).…”

Section: Tabla IX Comparación De Los Resultados De Los Rnebpn Hospitunclassified

Pronóstico Neonatal Del Recién Nacido De Muy Bajo Peso: Hospital Regional De Puerto Montt, 2000-2005

M¹,

H²,

F³

et al. 2007

Rev. chil. obstet. ginecol.

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RESUMENObjetivos: Describir patologías obstétricas asociadas, manejo perinatal y pronóstico neonatal del recién nacido de muy bajo peso al nacer (RNMBPN). Método: Estudio transversal efectuado en el Hospital de Puerto Montt, Chile, en 347 RNMBPN, en el periodo 2000 -2005. Resultados: La incidencia de RNMBPN fue de 1,59 %. El 70% de las pacientes recibió corticoides prenatales. La principal causa de interrupción fue el síndrome hipertensivo del embarazo. El 68,5% de los partos fueron por cesárea. El 23,7% y 9,3% presentó depresión neonatal severa al minuto y cinco minutos de vida, respectivamente. La cesárea se asoció a una reducción significativa del riesgo de depresión neonatal severa y muerte neonatal. Las principales complicaciones neonatales fueron el síndrome de dificultad respiratoria (61,5%) y sepsis neonatal (24,7%). El 29,7% de los recién nacidos fallece. Las causas de muerte son la prematurez (44,7%), las infecciones (30,1%) y las malformaciones congénitas (14,6%). Conclusiones: En nuestro centro el manejo los RNMBPN presentó un aumento significativo del uso de corticoides antenatales, de surfactante y asistencia ventilatoria con CPAP nasal. Hubo una reducción significativa de la depresión neonatal severa a los 5 minutos de vida. La sobrevida neonatal presentó un aumento significativo en el cuartil de 500 a 749 gramos. La cesárea se asocia a una disminución significativa de la depresión neonatal severa y muerte neonatal.

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“…5 A large multicenter survey report, including 37 Japanese NICUs of level III intensive cares and 2,145 VLBW infants, revealed that the incidence of sepsis was 8% in 2003. 24 The Neonatal Research Network of Japan also reported that 492 (5.0%) of 9,812 VLBW infants, who were born from 2006-2008, developed LOS (Table 1). 25 A current issue is how to control and prevent LOS in VLBW infants in Japan.…”

Section: Recent Epidemiology Incidencementioning

confidence: 98%

Recent epidemiology of neonatal sepsis in Japan: did the strategies to control and prevent MRSA transmission lead to a reduction in the incidence of late-onset sepsis?

Morioka¹,

Iwatani²,

Koda³

et al. 2014

RRN

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Neonatal sepsis is a significant cause of morbidity and mortality in newborns, particularly in the preterm or low birth weight infant. In this epidemiologic review regarding neonatal sepsis, the recent epidemiology and causative pathogens in Japan are described and compared with data from international organizations. Recent Japanese multicenter studies report the incidence of neonatal sepsis at 0.74%. Although the incidence of early-onset sepsis has been low (0.13%), approximately 5% of very or extremely low birth weight infants develop late-onset sepsis with a high mortality rate. In Japan for such cases, the most predominant causative pathogen is methicillin-resistant Staphylococcus aureus; internationally, the most commonly reported pathogen is coagulase-negative staphylococci. It is our contention that the incorporation of the strategies to control and to prevent health care-associated MRSA transmission has contributed to the reduction in the incidence of late-onset sepsis.

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Morbidity and Mortality of Infants With Very Low Birth Weight in Japan: Center Variation

Abstract: The overall survival rate for very low birth weight infants among neonatal centers in Japan was approximately 90%. However, differences in the morbidity and mortality were observed among these centers.

Cited by 225 publications

References 15 publications

Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience

Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience

Pronóstico Neonatal Del Recién Nacido De Muy Bajo Peso: Hospital Regional De Puerto Montt, 2000-2005

Recent epidemiology of neonatal sepsis in Japan: did the strategies to control and prevent MRSA transmission lead to a reduction in the incidence of late-onset sepsis?

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