Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial

Hu, Yanfeng; Huang, Chang‐Ming; Sun, Yihong; Su, Xiangqian; Cao, Hui; Hu, Jian‐Kun; Xue, Yingwei; Suo, Jian; Tao, Kaixiong; He, Xianli; H, Wei; Ying, Mingang; Hu, Weiguo; Du, Xiaohui; Chen, Pingyan; Liu, Hao; Zheng, Chao‐Hui; Liu, Fenglin; Yu, Jiang; Li, Ziyu; Zhao, Gang; Chen, Xinzu; Wang, Kuan; Li, Ping; Xing, Jiadi; Li, Guoxin

doi:10.1200/jco.2015.63.7215

Cited by 611 publications

(560 citation statements)

References 29 publications

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“…To decrease the mortality and morbidity rates, the inclusion of only appropriate candidates for surgical procedures and the selection of the appropriate LNs for dissection are mandatory. 2 For these reasons, correct intraoperative staging of metastatic LNs is essential for developing an individualized surgery. [3][4][5] Currently, the assessment of regional metastatic LNs is usually conducted via an imagological diagnosis, such as computed tomography (CT), magnetic resonance imaging (MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET).…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of dextran-coated iron oxide nanoclusters for real-time regional lymph node mapping

Fu¹,

Zhou²,

Wang³

et al. 2017

IJN

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The intraoperative precision cleaning of lymph nodes (LNs) is an essential component of treating neoplastic disease. To develop efficient probes for the targeted detection of LNs that could act as carriers for the specific diagnosis and treatment of metastatic LNs in the future, dextran-coated iron oxide nanoclusters (DIONs) were synthesized using a one-pot coprecipitation procedure. These modified DIONs have good water dispersibility, cytocompatibility, an optimum size, and a stable, dark brown color for LN imaging. In this study, cytotoxicity was evaluated using lymphatic endothelial cells (LECs) to predict biosafety and biocompatibility. Most importantly, the effectiveness of DIONs in mapping perigastric LNs in Sprague Dawley rats following injection into the gastric submucosal layer was demonstrated. In addition, a long-term tracing in vivo (from 4 days to 3 months) indicated that the DIONs had good biosafety and biocompatibility according to an evaluation of the behavior and blood biochemistry of the rat and a histopathological examination of the important organs.

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Section: Introductionmentioning

confidence: 99%

One-pot synthesis of dextran-coated iron oxide nanoclusters for real-time regional lymph node mapping

Fu¹,

Zhou²,

Wang³

et al. 2017

IJN

Self Cite

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“…Recently, Katai and colleagues of the Japan Clinical Oncology Group (JCOG0912) confirmed the noninferiority and safety of LADG compared to ODG in terms of short-term adverse and clinical outcomes of 912 early gastric cancer patients (LADG: 457 and ODG: 455 patients) (12 groups were published, in which both studies concluded the non-inferiority of laparoscopic surgeries in early and advanced gastric cancer, respectively (13,14).…”

mentioning

confidence: 99%

Randomized controlled trials evaluating laparoscopic vs. open distal gastrectomy for gastric cancer in 2016: a trilogy finally!

Kim¹,

Yang²

2017

Transl. Gastroenterol. Hepatol.

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“…Equivalent long-term survival outcomes in patients with early gastric cancer were also reported in a randomized control trial (9). Consequently, LG is generally regarded as one of the standard treatments for early gastric cancer, and it is expected that the indications for LG will expand further to advanced gastric cancer (10).…”

Section: Introductionmentioning

confidence: 87%

Robotic gastrectomy for gastric cancer

Tokunaga

Kaito

Sugita

et al. 2017

Transl. Gastroenterol. Hepatol.

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Correspondence to: Masanori Tokunaga. 6-5-1, Kashiwanoha, Kashiwa, 277-8577 Japan. Email: mtokunag@east.ncc.go.jp.Abstract: The number of robotic gastrectomy (RG) performed per year has been increasing, particularly in East Asia where the incidence of gastric cancer is high and approximately half of the cases are diagnosed as early gastric cancer. With articulated devices of RG, surgeons are able to perform every procedure more meticulously, which can result in less bleeding and damage to organs. There are many single arm and comparative studies, and these study showed similar trends, which included relatively less estimated blood loss and longer operation time following RG than laparoscopic gastrectomy (LG), equivalent number of harvested lymph nodes and similar length of postoperative hospital stay between RG and LG. Considering the results of these retrospective comparative studies, RG seems to be as feasible as LG in terms of early surgical outcomes. However, medical expense of RG is approximately twice as much as that of LG. Lack of solid evidence in terms of long-term outcomes is another problem. Considering the higher medical expenses associated with RG, its superiority in terms of long-term survival outcomes needs to be confirmed in the future for it to be accepted more widely.

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Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial

Abstract: Experienced surgeons can safely perform LG with D2 lymphadenectomy for AGC.

Cited by 611 publications

References 29 publications

One-pot synthesis of dextran-coated iron oxide nanoclusters for real-time regional lymph node mapping

One-pot synthesis of dextran-coated iron oxide nanoclusters for real-time regional lymph node mapping

Randomized controlled trials evaluating laparoscopic vs. open distal gastrectomy for gastric cancer in 2016: a trilogy finally!

Robotic gastrectomy for gastric cancer

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