Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: Results of a prospective phase I trial

Johannsen, Manfred; Gneveckow, Uwe; Taymoorian, Kasra; Thiesen, Burghard; Waldöfner, Norbert; Scholz, Robert; Jung, Klaus; Jordan, Andreas; Wust, Peter; Loening, Stefan A.

doi:10.1080/02656730601175479

Cited by 339 publications

(219 citation statements)

References 27 publications

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“…Acute urinary retention occurred in four patients with previous history of urethral stricture. Treatment-related morbidity was moderate and quality of life was only slightly and temporarily impaired [40].…”

Section: Magnetic Fluid Hyperthermia In Recurrent Prostate Carcinomamentioning

confidence: 97%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

745

556

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Magnetic fluids are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. The latter technique that has been developed as a cancer treatment for several decades comprises the injection of magnetic nanoparticles into tumors and their subsequent heating in an alternating magnetic field. Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy. Numerous groups are working in this field worldwide, but only one approach has been tested in clinical trials so far. Here, we summarize the clinical data gained in these studies on magnetic fluid induced hyperthermia.

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Section: Magnetic Fluid Hyperthermia In Recurrent Prostate Carcinomamentioning

confidence: 97%

Clinical applications of magnetic nanoparticles for hyperthermia

Thiesen¹,

Jordan

2008

International Journal of Hyperthermia

745

556

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show abstract

“…More complete evaluation of clinical outcomes is to be assessed in a phase II study on 65 patients with recurrent glioblastoma multiforme. Later on, the research group headed by Jordan applied their methodology for the treatment of prostate cancer [28,37]. An overview on their findings is provided in Table 1.…”

Section: Experimental/theoretical Modelling Studies Of Magnetic Nanopmentioning

confidence: 99%

A review on hyperthermia via nanoparticle-mediated therapy

et al. 2017

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“…[702] Since then, numerous animal experiments and studies were carried out to further the potentiate of this technique toward a more practical and safer treating for cancers, especially for the case of gliomas and prostate cancers. [20,703] The heating efficiency of the employed MNPs is of great importance to improve the overall hyperthermia process with lower doses of MNPs. [704] SAR or specific loss power (SLP) are the general terms to define transformation of magnetic energy into heat due to an externally applied alternative magnetic field.…”

Section: Wwwadvancedsciencenewscom Wwwadvhealthmatdementioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Morbidity and quality of life during thermotherapy using magnetic nanoparticles in locally recurrent prostate cancer: Results of a prospective phase I trial

Cited by 339 publications

References 27 publications

Clinical applications of magnetic nanoparticles for hyperthermia

Clinical applications of magnetic nanoparticles for hyperthermia

A review on hyperthermia via nanoparticle-mediated therapy

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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