More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

Ferdousi, Leyla Vahidi; Rocheteau, Pierre; Chayot, Romain; Montagne, Benjamin; Chaker, Zayna; Flamant, Patricia; Tajbakhsh, Shahragim; Ricchetti, Miria

doi:10.1016/j.scr.2014.08.005

Cited by 75 publications

(59 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This idea also underscores the proposed role of cancer stem cells in tumor formation and spreading (17). It is now well understood that precise DNA repair is critical in stem cells (14), making them more resistant to DNA damage (18). On the other hand, adult tissue stem cells face genotoxic stimuli over decades.…”

Section: Biological Background Of Ageing and Impact On Cancer Formationmentioning

confidence: 95%

Ageing as an Important Risk Factor for Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Biological Background Of Ageing and Impact On Cancer Formationmentioning

confidence: 95%

Ageing as an Important Risk Factor for Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Quiescent and activated satellite cells differ, also, in metabolic status since the former have fewer mitochondria and a glycolytic metabolism compared to activated cells; moreover quiescent cells repair DNA damage more efficiently than their progeny [49]. …”

Section: Satellite Cellsmentioning

confidence: 99%

Muscle stem cell and physical activity: what point is the debate at?

et al. 2017

View full text Add to dashboard Cite

AbstractIn the last 15 years, it emerged that the practice of regular physical activity reduces the risks of many diseases (cardiovascular diseases, diabetes, etc.) and it is fundamental in weight control and energy consuming to contrast obesity. Different groups proposed many molecular mechanisms as responsible for the positive effects of physical activity in healthy life. However, many points remain to be clarified. In this mini-review we reported the latest observations on the effects of physical exercise on healthy skeletal and cardiac muscle focusing on muscle stem cells. The last ones represent the fundamental elements for muscle regeneration post injury, but also for healthy muscle homeostasis.Interestingly, in both muscle tissues the morphological consequence of physical activity is a physiological hypertrophy that depends on different phenomena both in differentiated cells and stem cells. The signaling pathways for physical exercise effects present common elements in skeletal and cardiac muscle, like activation of specific transcription factors, proliferative pathways, and cytokines. More recently, post translational (miRNAs) or epigenetic (DNA methylation) modifications have been demonstrated. However, several points remain unresolved thus requiring new research on the effect of exercise on muscle stem cells.

show abstract

“…Satellite cells seem to be more resistant to DNA damage and capable of repairing these DNA lesions more efficiently compared with their committed progeny [74]. Nevertheless, the combined effect of an exposure to genotoxic stresses throughout life and a decline in antioxidant capacity of old satellite cells [75] seems to have a deleterious impact on their genomic integrity.…”

Section: Intrinsic Modifications In Aged Satellite Cellsmentioning

confidence: 99%