Morin hydrate inhibits platelet activation and clot retraction by regulating integrin αIIbβ3, TXA2, and cAMP levels

Nam, Gi Suk; Lee, Kyu-Shik; Nam, Kyung‐Soo

doi:10.1016/j.ejphar.2019.172734

Cited by 9 publications

(8 citation statements)

References 45 publications

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“…and/or by interfering with intracellular Ca 2+ signaling [69]. Of other flavones, in one paper morin was found to dampen collagen-and thrombin-induced platelet responses with suggested roles of the PLC, PI3K, Akt, MAPK (p38, ERK) and cAMP pathways [70].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…69 Of other flavones, in one paper morin was found to dampen collagen- and thrombin-induced platelet responses with suggested roles of the PLC, PI3K, Akt, MAPK (p38, ERK), and cAMP pathways. 70 The flavonols fisetin and kaempferol (10 À4 M) may have similar inhibiting profiles regarding collagen and thrombin stimulation. Kaempferol was shown to attenuate thrombininduced phosphorylation of PI3K, Akt, ERK, and p38, and suppress murine thrombus formation.…”

Section: Platelet Activation Affected By Flavonoid Polyphenols (Class...mentioning

confidence: 99%

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Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

et al. 2021

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Cardiovascular disease, in particular due to arterial thrombosis, is a leading cause of mortality and morbidity, with crucial roles of platelets in thrombus formation. For multiple plant-derived phytochemicals found in common dietary components, claims have been made regarding cardiovascular health and antiplatelet activities. Here we present a systematic overview of the published effects of common phytochemicals, applied in vitro or in nutritional intervention studies, on agonist-induced platelet activation properties and platelet signaling pathways. Comparing the phytochemical effects per structural class, we included general phenols: curcuminoids (e.g., curcumin), lignans (honokiol, silybin), phenolic acids (caffeic and chlorogenic acid), derivatives of these (shikimic acid) and stilbenoids (isorhapontigenin, resveratrol). Furthermore, we evaluated the flavonoid polyphenols, including anthocyanidins (delphinidin, malvidin), flavan-3-ols (catechins), flavanones (hesperidin), flavones (apigenin, nobiletin), flavonols (kaempferol, myricetin, quercetin), isoflavones (daidzein, genistein); and terpenoids including carotenes and limonene; and finally miscellaneous compounds like betalains, indoles, organosulfides (diallyl trisulfide) and phytosterols. We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance. Lastly, we provide guidance on which compounds are of interest for further platelet-related research.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Platelet Activation Affected By Flavonoid Polyphenols (Class...mentioning

confidence: 99%

Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

et al. 2021

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“…Nam et al 63 reported the in vitro antiplatelet and anticoagulant activity of the flavonoid morin, a metabolite in Prunus dulcis (Mill.) D.A.…”

Section: Morinmentioning

confidence: 99%

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

Martínez

Campos

2023

Food Funct.

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“…Primarily, phospholipase C fosters the formation of the second messenger (diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3)) from the cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) as well as the activation of phospholipases A2 and D, whose role in maintaining bone balance is poorly understood [ 175 ]. While the DAG remains membrane-bounded, IP 3 , which is soluble, diffuses out of the parathyroid cells and binds to calcium channel receptors (inositol trisphosphate receptor—IP3R) located in the endoplasmic reticulum, thereby fostering the release of Ca 2+ in the cytosol and activating other Ca 2+ -regulated signaling axes [ 175 ]. Alternatively, intracellular calcium, especially in osteoblast cells, exerts some form of regulation on the bone homeostasis process.…”

Section: Cellular and Molecular Mechanisms Of Bone Health-promoting P...mentioning

confidence: 99%

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

Okagu

Ezeorba

Aguchem

et al. 2022

IJMS

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The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs’ adoption. This review discusses the pathological development of some BDs, the NP-targeted components, and the actions exerted on bone remodeling signaling pathways (e.g., Receptor Activator of Nuclear Factor κ B-ligand (RANKL)/monocyte/macrophage colony-stimulating factor (M-CSF)/osteoprotegerin (OPG), mitogen-activated protein kinase (MAPK)s/c-Jun N-terminal kinase (JNK)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Kelch-like ECH-associated protein 1 (Keap-1)/nuclear factor erythroid 2–related factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1), Bone Morphogenetic Protein 2 (BMP2)-Wnt/β-catenin, PhosphatidylInositol 3-Kinase (PI3K)/protein kinase B (Akt)/Glycogen Synthase Kinase 3 Beta (GSK3β), and other signaling pathways). Although majority of the studies on the osteoprotective properties of NPs against BDs were conducted ex vivo and mostly on animals, the use of NPs for treating human BDs and the prospects for future development remain promising.

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Morin hydrate inhibits platelet activation and clot retraction by regulating integrin αIIbβ3, TXA2, and cAMP levels

Cited by 9 publications

References 45 publications

Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis

Bioactive compounds and functional foods as coadjuvant therapy for thrombosis

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases

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