Moringa isothiocyanate-1 is bioaccessible and bioavailable as a stable unmodified compound

Wolff, Khea; Jaja-Chimedza, Asha; Kim, Youjin; Waterman, Carrie; Poulev, Alexander; Raskin, Ilya; Ribnicky, David M.

doi:10.1016/j.phytol.2020.05.001

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…Moreover, it was reported that the structural difference from other isothiocyanates does not impact MIC efficacy but rather contributes to their stability. As stated, purified MIC is a white crystalline powder stable at 25 °C, while SFN and PEITC are volatile, viscous liquids [ 33 ].…”

Section: Isothiocyanate Metabolismmentioning

confidence: 99%

A Comparative Review of Key Isothiocyanates and Their Health Benefits

Olayanju,

Bozic,

Naidoo

et al. 2024

Nutrients

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Isothiocyanates are biologically active products resulting from the hydrolysis of glucosinolates predominantly present in cruciferous vegetables belonging to the Brassicaceae family. Numerous studies have demonstrated the diverse bioactivities of various isothiocyanates, encompassing anticarcinogenic, anti-inflammatory, and antioxidative properties. Nature harbors distinct isothiocyanate precursors, glucosinolates such as glucoraphanin and gluconastrin, each characterized by unique structures, physical properties, and pharmacological potentials. This comprehensive review aims to consolidate the current understanding of Moringa isothiocyanates, mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates such as sulforaphane and phenyl ethyl isothiocyanates. The focus is directed toward elucidating differences and similarities in the efficacy of these compounds as agents with anticancer, anti-inflammatory, and antioxidative properties.

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Section: Isothiocyanate Metabolismmentioning

confidence: 99%

A Comparative Review of Key Isothiocyanates and Their Health Benefits

Olayanju,

Bozic,

Naidoo

et al. 2024

Nutrients

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“…In contrast to liquid sulforaphane, MIC-1 contains a sugar group that makes it a stable solid at room temperatures [2]. MIC-1's chemical structure also improves its in vivo stability and bioavailability [2,3]. Sixty percent of MIC-1, applied as pure compound or as a component of moringa seed extract, was not degraded in the in vitro gastrointestinal digestion model [3].…”

Section: Introductionmentioning

confidence: 99%

“…MIC-1's chemical structure also improves its in vivo stability and bioavailability [2,3]. Sixty percent of MIC-1, applied as pure compound or as a component of moringa seed extract, was not degraded in the in vitro gastrointestinal digestion model [3]. Orally administered MIC-1, up to 100 mg/kg bw/d, did not cause toxic effects in rats [4].…”

Section: Introductionmentioning

confidence: 99%

Moringa isothiocyanate-1 inhibits LPS-induced inflammation in mouse myoblasts and skeletal muscle

et al. 2022

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This study aims to investigate the anti-inflammatory effects of moringa isothiocyanate-1 (MIC-1) extracted from seeds of Moringa oleifera Lam. in lipopolysaccharide (LPS)-induced inflammation models. MIC-1 decreased nitric oxide production and reduced the expression of pro-inflammatory markers (TNF-α, Ifn-α, IL-1β, IL-6) in C2C12 myoblasts. The daily oral treatment of MIC-1 (80 mg/kg) for three days significantly reduced the expression of pro-inflammatory markers in gastrocnemius muscle tissue of LPS-treated C57BL/6 male mice. Transcriptomic analysis provided further insights into the inhibitory effects of MIC-1 on the LPS-induced inflammation, which suggested that MIC-1 affects inflammation and immunity-related genes in myoblasts and skeletal muscle tissue. MIC-1 inhibited the nuclear accumulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in the LPS-treated myoblasts. Our data support the hypothesis that the MIC-1’s effects in the muscle cells are mediated through the inhibition of the NF-κB translocation in the nucleus, which, in turn, results in immunomodulating and anti-inflammatory responses at the gene expression levels.

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“…Wolff et al (2020) [4] suggested that Moringa isothiocyanate is protected from typical isothiocyanate metabolic modifications during uptake probably because of its unique glycosidic moiety. On the other hand, metabolites of the mercapturic acid pathway for sulforaphane and iberin, the major isothiocyanates in broccoli, were detected and quantitatively measured in human plasma and urine after dietary consumption of broccoli [5].…”

Section: Introduction mentioning

confidence: 99%

Investigation of the False Positive Results of Dithiocarbamate Pesticides due to Endogenous Nonpathogenic Carbon Disulfide in Organically Grown Plants (Moringa oleifera)

Ma’mun¹

2020

JPP

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Moringa isothiocyanate-1 is bioaccessible and bioavailable as a stable unmodified compound

Cited by 8 publications

References 17 publications

A Comparative Review of Key Isothiocyanates and Their Health Benefits

A Comparative Review of Key Isothiocyanates and Their Health Benefits

Moringa isothiocyanate-1 inhibits LPS-induced inflammation in mouse myoblasts and skeletal muscle

Investigation of the False Positive Results of Dithiocarbamate Pesticides due to Endogenous Nonpathogenic Carbon Disulfide in Organically Grown Plants (Moringa oleifera)

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