Morphologic and Functional Evaluations During Development, Resolution, and Relapse of Uveitis-Associated Cystoid Macular Edema

Munk, Marion R.; Bolz, Matthias; Huf, Wolfgang; Sulzbacher, Florian; Roberts, Philipp; Simader, Christian; Rückert, Ralph I.; Kiss, Christopher

doi:10.1097/iae.0b013e318285cc52

Cited by 38 publications

(34 citation statements)

References 49 publications

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“…Furthermore, Sigler et al 22 supposed that the earliest retinal damage involved the INL with cystic changes and then the OPL and subretinal space. This pattern was very similar to that of active uveitic CMO,23 supporting again the inflammatory pathogenesis of PCMO. Nevertheless, FA has the limitation that cannot well visualise the DCP,10 which is the main retinal vascular layer altered in PCMO.…”

Section: Discussionsupporting

confidence: 77%

Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

et al. 2018

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Section: Discussionsupporting

confidence: 77%

Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

et al. 2018

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“…Previous studies of epiretinal membranes and uveitic macular edema also have found that epiretinal membranes limit the response to therapy, as eyes with epiretinal membranes had significantly worse acuity at 3 months after intravitreal triamcinolone acetonide injection 9 and were significantly more likely to fail medical therapy for uveitic macular edema. 10 Our data, though limited by sample size, support this concept.…”

Section: Discussionmentioning

confidence: 84%

“…7,8 Detrimental clinical effects of epiretinal membrane formation on uveitic macular edema have been described. Epiretinal membranes have been associated with worse visual acuity in uveitic macular edema patients 3 months after treatment with intravitreal triamcinolone acetonide, 9 as well as a higher risk of failing medical therapy for uveitic macular edema. 10 In one study, foveal involvement of the epiretinal membrane and focal attachment of the epiretinal membrane to the inner retinal surface were predictors of poor vision.…”

mentioning

confidence: 99%

Epiretinal Membranes in Uveitic Macular Edema: Effect on Vision and Response to Therapy

Lehpamer

Moshier

Pahk

et al. 2014

American Journal of Ophthalmology

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Purpose To evaluate the effects of epiretinal membranes on the response of uveitic macular edema to therapy and on visual acuity outcomes. Design Retrospective case series. Methods 104 eyes of 77 patients with uveitic macular edema were identified at a tertiary care center. Epiretinal membranes were diagnosed when identified by two investigators’ grading of spectral-domain optical coherence tomography and scored for the presence or absence of surface wrinkling. Outcomes included best corrected visual acuity, central subfield thickness, and rates of macular edema improvement (>20% reduction in central subfield thickness) and resolution (reduction of central subfield thickness to <315 μm) at 3 and 6 months follow-up. Results 72 eyes of 59 patients had an epiretinal membrane on presentation. Eyes without epiretinal membranes and with epiretinal membranes without surface wrinkling were not significantly different at presentation or at 3 and 6 months follow-up. Conversely, eyes with an epiretinal membrane with retinal surface wrinkling had a greater proportion of eyes with 20/200 or worse visual acuity at presentation, and had worse mean acuities at 3 months (20/94 vs. 20/35 for eyes without an epiretinal membrane, P=0.002) and at 6 months follow-up (20/110 vs. 20/36 for eyes without an epiretinal membrane, P=0.02). At 6 months of follow-up the mean central subfield thicknesses were: eyes without an epiretinal membrane, 338 ± 23 μm; and eyes with an epiretinal membrane and surface wrinkling, 405 ± 22 μm (P=0.05). Conclusions In eyes with epiretinal membranes and retinal surface wrinkling, uveitic macular edema had a poorer visual acuity response to medical therapy and thicker maculae at 6 months.

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“…Besides detection of various macular pathologies, measurement of general anatomical indices such as central retinal thickness (CRT) and macular volume (MV) has been correlated in previous studies with visual acuity and response to therapy. 2,3 While previous studies using SD-OCT focused on uveitis patients with manifest secondary changes of the retina, primarily CME, [2][3][4][5][6][7][8][9][10][11][12][13][14] we were interested to analyze the macular morphology in a large series of consecutive patients with different types of uveitis, using SD-OCT. We assessed the CRT, MV, and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), ERM with (ERM+) and ERM without (ERM − ) retinal surface wrinkling.…”

Section: Introductionmentioning

confidence: 99%

Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

Grajewski

Boelke

Adler

et al. 2016

Eye

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Purpose To analyze the macular structure in a large series of consecutive patients with different types of uveitis using spectraldomain optical coherence tomography (SD-OCT). Patients and methods Five hundred eyes of 500 consecutive patients with anterior, intermediate, posterior, and panuveitis underwent standardized macular examination using SD-OCT. Central retinal thickness (CRT), macular volume (MV), and presence of cystoid macular edema (CME), diffuse macular edema (DME), serous retinal detachment (SRD), epiretinal membrane with (ERM+) and without (ERM − ) retinal surface wrinkling were determined. Results The anatomic location of inflammation affected significantly CRT and MV (Po0.001, respectively), with the highest values in intermediate and panuveitis. CME was seen in 25% of all uveitic eyes, DME in 11%, SRD in 8%, ERM+ in 18%, and ERM − in 13%. CME was most frequent in intermediate (40%) and panuveitis (36%); DME was most frequent in panuveitis (18%) and posterior uveitis (17%); SRD was most frequent in panuveitis (15%) and posterior uveitis (10%); ERM+ was most frequent in panuveitis (45%) and intermediate uveitis (30%); and ERM − was most frequent in intermediate (14%) and posterior uveitis (15%). Conclusion SD-OCT of the macula is recommended for all uveitis patients. CRT, MV, and the incidence of CME were highest in intermediate and panuveitis.

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Morphologic and Functional Evaluations During Development, Resolution, and Relapse of Uveitis-Associated Cystoid Macular Edema

Abstract: Different morphologic patterns in uvCME may represent different stages in uvCME progression, and initial morphologic appearance can be linked to the clinical prognosis after the treatment.

Cited by 38 publications

References 49 publications

Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

Optical coherence tomography angiography in pseudophakic cystoid macular oedema compared to diabetic macular oedema: qualitative and quantitative evaluation of retinal vasculature

Epiretinal Membranes in Uveitic Macular Edema: Effect on Vision and Response to Therapy

Spectral-domain optical coherence tomography findings of the macula in 500 consecutive patients with uveitis

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