Morphological and biochemical changes in the livers of Wistar rats following subacute exposure to three technical brominated flame retardant mixtures

Litens, Sabina; Esteban, Javier; Schrenk, Dieter; Germer, Silke; Ven, Leo van der; Håkansson, Helen

doi:10.1016/j.toxlet.2008.06.620

Toxicology Letters

2008

DOI: 10.1016/j.toxlet.2008.06.620

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Morphological and biochemical changes in the livers of Wistar rats following subacute exposure to three technical brominated flame retardant mixtures

Sabina Litens

Javier Esteban

Dieter Schrenk

et al.

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2012

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“…[255][256][257][258][259][260][261][262] Chemical risk assessment procedures commonly rely on determining the effects of a single substance. Over the last decade, however, a number of welldesigned studies have investigated the effects of multi-component mixtures (1)(2)(3)(4). High-level exposure to cadmium (Cd) is usually a result of environmental contamination due to various anthropogenic activities (5,6).…”

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Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Ćurčić

Janković²,

Jacević

et al. 2012

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to see how a mixture of cadmium (Cd) and decabrominated diphenyl ether (BDE209) affect thyroid function, namely thyroid-stimulating hormone (TSH), thyroxin (T4), free thyroxin (FT4), triiodothyronin (T3), and free triiodothyronin (FT3) in Wistar rats (eight per group) receiving either a single substance or their combination by gavage for 28 days. Three groups were receiving Cd alone in the doses of 2.5 mg kg -1 , 7.5 mg kg -1 , or 15 mg kg -1 b. w. a day, three groups were receiving BDE209 in the doses of 1000 mg kg -1 , 2000 mg kg -1 , or 4000 mg kg -1 b. w. a day, while nine groups were receiving different mixtures of Cd and BDE209 in these doses (3x3 design). The results have indicated that the Cd+BDE209 mixtures more potently disrupt thyroid hormone homeostasis than would be expected from these chemicals alone.

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mentioning

confidence: 99%

Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Ćurčić

Janković²,

Jacević

et al. 2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

show abstract

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Morphological and biochemical changes in the livers of Wistar rats following subacute exposure to three technical brominated flame retardant mixtures

Cited by 1 publication

References 0 publications

Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

Combined effects of cadmium and decabrominated diphenyl ether on thyroid hormones in rats

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