Morphological and electrophysiological properties of ACCx nociceptive neurons in rats

Yamamura, Hozumi; Iwata, Koichi; Tsuboi, Y.; Toda, Kazuo; Kitajima, Kaori; Shimizu, Nobutaka; Nomura, Hajime; Hibiya, Jiro; Fujita, Satoshi; Sumino, Rhyuji

doi:10.1016/0006-8993(96)00561-6

Cited by 103 publications

(46 citation statements)

References 22 publications

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“…In conscious rats, many neurons in the ACC are activated at the onset of a noxious stimulation (47, 48). These neurons typically have very large or whole body receptive fields (49), supporting the idea that the ACC plays a role in the aversive/motivational aspects of pain rather than the sensory/discriminative aspects. (50, 51).…”

Section: Brain Activity In Response To Pain and Pain Reliefmentioning

confidence: 77%

Brain Circuits Encoding Reward from Pain Relief

Navratilova

Atcherley

Porreca

2015

Trends in Neurosciences

182

129

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Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in our understanding of reward circuits underlying positive reinforcement, less is known about the circuits underlying the hedonic and reinforcing actions of pain relief. We review findings from electrophysiological, neuroimaging and behavioral studies supporting the concept that the rewarding effect of pain relief requires opioid signaling in the anterior cingulate cortex, activation of midbrain dopamine neurons and release of dopamine in the nucleus accumbens. Understanding of circuits that govern the reward of pain relief may allow the discovery of more effective and satisfying therapies for patients with acute and chronic pain.

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Section: Brain Activity In Response To Pain and Pain Reliefmentioning

confidence: 77%

Brain Circuits Encoding Reward from Pain Relief

Navratilova

Atcherley

Porreca

2015

Trends in Neurosciences

182

129

View full text Add to dashboard Cite

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“…Both animal and human studies indicate that neurons in the ACC respond to peripheral painful stimuli [6,28,50], and injury triggers the activation of immediate early genes in the ACC [27,29]. Unlike the somatosensory cortex, neurons in the ACC have wide diffuse receptive fields, and often contain the whole body of an animal, supporting its role in coding unpleasantness of pain [6,51,52]. Supporting this hypothesis, lesions of the ACC or inhibition of excitatory synaptic transmission in the ACC produces antinociceptive effects or analgesia [24,25] and block formalin-induced conditioned place avoidance [26].…”

Section: Resultsmentioning

confidence: 99%

Pavlovian Fear Memory Induced by Activation in the Anterior Cingulate Cortex

et al. 2005

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Identifying higher brain central region(s) that are responsible for the unpleasantness of pain is the focus of many recent studies. Here we show that direct stimulation of the anterior cingulate cortex (ACC) in mice produced fear-like freezing responses and induced long-term fear memory, including contextual and auditory fear memory. Auditory fear memory required the activation of N-methyl-D-aspartate (NMDA) receptors in the amygdala. To test the hypothesis that neuronal activity in the ACC contributes to unpleasantness, we injected a GABA A receptor agonist, muscimol bilaterally into the ACC. Both contextual and auditory memories induced by foot shock were blocked. Furthermore, activation of metabotropic glutamate receptors in the ACC enhanced behavioral escape responses in a noxious hot-plate as well as spinal nociceptive tail-flick reflex. Our results provide strong evidence that the excitatory activity in the ACC contribute to pain-related fear memory as well as descending facilitatory modulation of spinal nociception.

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“…Activity-induced MEMRI takes advantage of the fast influx and slow efflux of Mn 2+ from the brain, so the Mn 2+ accumulation pattern is retained for several days, enabling MRI to be performed after the noxious electrical stimuli. In combination with the basic properties of MEMRI (i.e., the paramagnetic nature of manganese and neural activity-dependent intracellular increases), activity-induced MRI can now be used for various applications including functional mapping of sensory pathways in awake and unrestrained animals [15] Large numbers of electrophysiological studies in non-human primates and other animals have identified nociceptivespecific neurons in different pain-related areas such as the primary and secondary somatosensory cortices, insula, and ACC [11,23,24]. However, a common finding across most of these studies is that nociceptive-specific neurons are distributed throughout the brain [9].…”

Section: Discussionmentioning

confidence: 99%