Morphological and Statistical Investigation of the Occurrence of ‘Tubule-Like Cells’ in the Renal Corpuscle of the Mouse Kidney Induced by Sex Hormones

Barberini, Fabrizio; Familiari, Giuseppe; Vittori, I; Carpino, F; Melis, M

doi:10.1159/000172942

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…It has been reported that androgen promotes the apperance of cuboidal cells in the parietal layer of the glomerular capsule of the mouse kidney [2]. Therefore, we examined the effects of castration and sex hormone treatment, and confirmed the same effect by testosterone, although no effect was brought about by estradiol.…”

Section: Discussionmentioning

confidence: 54%

“…Since the first report by Selye [12] in 1939, a large number of studies have been reported on the cuboidal epithelium in the parietal layer of the glomerular capsule of adult male mice [1,2,[4][5][6][7][8][9]. In the present study, we examined the appearance of this epithelium and expressed it as percentages of renal corpuscles with cuboidal cells in the parietal layer.…”

Section: Discussionmentioning

confidence: 99%

“…In the mouse nephron, the sexual dimorphism is observed in the parietal epithelium of the glomerular capsule, so that and the male parietal layer consists of cuboidal cells [1,2,[4][5][6][7][8][9]12]. Strain differences in the cuboidal epithelium were also suggested by Hamada [6].…”

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confidence: 99%

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Morphometrical Analysis of Sex and Strain Differences in the Mouse Nephron.

Yabuki

Suzuki

Matsumoto

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. In the present study, we investigated the sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by measuring the percentage of renal corpuscles with cuboidal cells in the parietal layer of the glomerular capsule, the diameter of renal corpuscles and the number of nuclei of epithelial cells in the proximal convoluted tubule. In ICR mice, the percentage of renal corpuscles with cuboidal cells and the diameter of renal corpuscles were larger in males than in females, and the numbers of nuclei were lower in males than in females. All of these parameters became similar to those of intact females by orchiectomy, and restored to levels similar to those in intact males after testosterone treatment to orchiectomized males. On the other hand, ovariectomy and estradiol treatment gave no effects to any of these parameters. Similar sexual dimorphisms were observed in BALB/c, C57BL/6, C3H/He and DBA/2 mice as in ICR mice, although the diameter of renal corpuscles was not significantly different between males and females in BALB/c mice. Strain differences were observed in each of these three parameters among the 5 strains. In conclusion, the present study demonstrated sexual dimorphisms, effects of castration and sex hormone treatment, and strain differences in the morphology of mouse kidney by morphometrical analysis.-KEY WORDS: kidney, morphometry, mouse, sex difference, strain difference.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Morphometrical Analysis of Sex and Strain Differences in the Mouse Nephron.

Yabuki

Suzuki

Matsumoto

et al. 1999

The Journal of Veterinary Medical Science

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“…3). The CPL of the glomerular capsule, which has a similar function to the proximal tubular epithelium [4], is a feature of the renal corpuscles in adult male mice in many strains [1,11,15]. Such a CPL is also found in the small percentage of renal corpuscles of female mice [2,15], and it was reported that the percentage of the renal corpuscles with a CPL is higher during proestrus and estrus [2].…”

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confidence: 97%

“…In this study, the renal corpuscles with a CPL area under 50% showed similar changes to the previous report [2], although the renal corpuscles with a CPL area over 50% were unchanged by the estrous cycle. It has been reported that testosterone and dehydroepitestosterone treatments promote the appearance of CPL in the renal corpuscles [1,15], although the effects of 17β-estradiol treatments have been denied in these reports. Both testosterone and dehydroepitestosterone are the precursors of estrogen, and it might be presumed that these hormones and/or other ovarian androgens, e.g.…”

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confidence: 99%

Effects of Estrous Cycle on the Mouse Kidney Morphology.

Yabuki

Maeda

Suzuki

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Although mice kidney morphology shows various sexual dimorphisms, the effect of the estrous cycle has not previously been discussed. In this study, we investigated the effects of the estrous cycle on kidney morphology, including renin-positive areas, of female DBA/2 mice. No effects were confirmed in most of the histometrical parameters, however, the percentage of the renal corpuscles in which cuboidal epithelium covered under 50% of the parietal layer was significantly higher during estrus compared to that during anestrus. KEY WORDS: DBA/2 mouse, estrous cycle, kidney morphology.

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A scanning electron microscope study of the neck segment of the rabbit nephron

Ojeda

Icardo

1991

Anat Embryol

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The three-dimensional structure of the neck segment (NS) of the rabbit nephrons was studied by scanning electron microscopy (after fracture, micro-dissection, or after corrosion nephron casts), and by the air-cast method. The NS was observed at the glomerulotubular junction in 68.5% of all nephrons. In every case the NS appeared as a straight tube with its long axis oriented radially in relation to the glomerulus. Although the external diameter of the NS was smaller than that of the proximal tubule, its luminal diameter was greater. No valve-like structures were observed. Three cell types were observed in the NS: parietal-like, tubule-like, and intermediate. Parietal-like cells showed the same morphology as the parietal cells of the Bowman's capsule. Parietal-like cells constituted the only cell type in 25% of the NS. Tubule-like cells showed morphologic characteristics similar to proximal tubule cells; however, their microvilli were less numerous and exhibited an irregular pattern. Intermediate cells presented an intermediate morphology between tubule-like and parietal cells. In 75% of all NS, the three cellular types were present at the same time. The presence of tubule-like and intermediate cells is interpreted as the result of metaplasic transformation of the parietal cells. Our observations suggest that, in rabbits, the presence of the NS can be explained on the basis of phenotypical lability of the cells located at the glomerulo-tubular junction.

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Morphological and Statistical Investigation of the Occurrence of ‘Tubule-Like Cells’ in the Renal Corpuscle of the Mouse Kidney Induced by Sex Hormones

Cited by 8 publications

References 10 publications

Morphometrical Analysis of Sex and Strain Differences in the Mouse Nephron.

Morphometrical Analysis of Sex and Strain Differences in the Mouse Nephron.

Effects of Estrous Cycle on the Mouse Kidney Morphology.

A scanning electron microscope study of the neck segment of the rabbit nephron

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