Effects of Estrous Cycle on the Mouse Kidney Morphology.

Yabuki, Akira; Maeda, Michiharu; Suzuki, Syusaku; Matsumoto, Mitsuharu; Kurohmaru, Masamichi; Hayashi, Yoshihiro; Taniguchi, Kazuyuki; Nishinakagawa, Hayao

doi:10.1292/jvms.63.461

Cited by 7 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent study demonstrated that development of vacuolar structures was stimulated by testosterone treatment but not affected by estradiol treatment [12]. In PAS-positive granules, although no effects of normal estrus have been identified [11], development of these granules is stimulated by estradiol treatment and inhibited by testosterone treatment [12]. These structures in male PCTs or female PSTs of DBA/2Cr mice were already confirmed as giant lysozomes by the electron microscopic studies [14,17].…”

Section: Discussionmentioning

confidence: 95%

“…Vacuolar structures were prominent in PCTs of males but not females [12][13][14]. Variously sized PAS-positive granules were prominent in PSTs of females but not males [11][12][13][15][16][17][18]. Although these studies demonstrated that the gender differences were induced by testosterone or estradiol [12,19], the developmental process responsible for these gender differences in mouse kidney morphology has not been investigated previously.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Development of Gender Differences in DBA/2Cr Mouse Kidney Morphology during Maturation

Okada

Yabuki

Matsumoto

et al. 2005

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Although we recently clarified sex-based differences in mouse kidney morphology, the developmental processes responsible for these gender differences during maturation remain unclear. The present study analyzed the morphometry of kidneys from 20-, 30-, 50-, 60-, 70-, 90-, 120-and 150-day-old DBA/2Cr mice. Total kidney weight and ratio of kidney weight to body weight were larger in males than females beginning at 50 days of age. The percentage of renal corpuscles exhibiting a cuboidal parietal layer was higher in males than in females in the 70-day and older mice. The diameter of cortical renal corpuscles was larger in males than in females beginning on day 90. The number of proximal convoluted tubular cell nuclei was higher in females than in males from day 90 onward. Vacuolar structures in the proximal convoluted tubular epithelium became prominent in 70-day-old males. PAS-positive granules in the proximal straight tubular epithelium became prominent in females on day 50. This paper is the first to describe the development of gender differences in mouse kidney morphology.

show abstract

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Development of Gender Differences in DBA/2Cr Mouse Kidney Morphology during Maturation

Okada

Yabuki

Matsumoto

et al. 2005

The Journal of Veterinary Medical Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…After the final wash, slides were mounted in Slowfade Light mounting medium (Molecular Probes) and examined using fluorescent microscopy. Pancreata for histological studies were fixed overnight in Bouin's fixative (20), paraffin-embedded, sectioned, and stained with hematoxylin͞eosin according to standard protocol.…”

Section: Generation Of the Rip-fas Cg Dna Construct And Evaluation Ofmentioning

confidence: 99%

Contribution of Fas to diabetes development

Savinov

Tcherepanov

Green

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell types. Fas have been shown to be expressed by insulin-producing beta cells in mice and humans. However, the importance of Fas in the development of autoimmune diabetes remains controversial. To further evaluate the importance of Fas in pathogenesis of diabetes, we generated NOD mice (nonobese diabetic mice developing spontaneous autoimmune diabetes) with beta cell-specific expression of a dominant-negative point mutation in a death domain of Fas, known as lpr cg or Fas cg . Spontaneous diabetes was significantly delayed in NOD mice expressing Fas cg , and the effect depended on the expression level of the transgene. However, Fas cg -bearing mice were still sensitive to diabetes transferred by splenocytes from overtly diabetic NOD mice. At the same time, Fas cg expression did neutralize the accelerating effect of transgenic Fas-ligand expressed by the same beta cells. Thus, both Fas-dependent and -independent mechanisms are involved in beta cell destruction, but interference with the Fas pathway early in disease development may retard or prevent diabetes progression.

show abstract

“…In addition, livers, lungs, adrenal glands, submandibular glands and testes from the mice were prepared in a similar manner for immunohistochemistry to investigate extra-renal renin expression. The number of renin-positive areas was quantified as previously described [9,12], and analyzed using one-way analysis of variance (Bonferroni/Donn test).…”

mentioning

confidence: 99%

Renin, Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in the Kidneys of Transgenic Tsukuba Hypertensive Mouse

et al. 2004

Self Cite

View full text Add to dashboard Cite

Abstract:The transgenic Tsukuba hypertensive mouse (THM), which expresses the human renin and angiotensinogen genes, develops hypertension secondary to increased renin-angiotensin system activity. The aim of the present study was to assess expression of the renin, cyclooxygenase-2 (COX-2), and neuronal nitric oxide synthase (nNOS) proteins in THM kidneys by immunohistochemical stainings. Renin expression was decreased in the THM kidneys when compared to kidneys from heterozygotes or control mice. Although no differences were observed in nNOS expression, overexpression of the COX-2 protein was observed in the macula densa cells in THM kidneys.

show abstract

Effects of Estrous Cycle on the Mouse Kidney Morphology.

Cited by 7 publications

References 17 publications

Development of Gender Differences in DBA/2Cr Mouse Kidney Morphology during Maturation

Development of Gender Differences in DBA/2Cr Mouse Kidney Morphology during Maturation

Contribution of Fas to diabetes development

Renin, Cyclooxygenase-2 and Neuronal Nitric Oxide Synthase in the Kidneys of Transgenic Tsukuba Hypertensive Mouse

Contact Info

Product

Resources

About