Morphology and Chromic Status of Red Blood Cells Are Significantly Influenced by Gestational Diabetes

Rajab, Ahmad Mamoun; Rahman, Saifur; Rajab, Tawfik Mamoun; Haider, Khawaja Husnain

doi:10.14740/jh449w

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…[26] Anisocytosis was reported to be more prevalent in GDM. [27] In their cohort study including 16971 adults Wang et al found that each unit increase of RDW was associated with a 16% higher incident diabetes and concluded that high RDW was associated with high risk of diabetes. [25] The number of studies assessing the association between RDW and GDM is scarce and there are conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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To assess the role of simple complete blood count (CBC) in prediction of gestational diabetes (GDM). Material and Method: Pregnant women screened for GDM in 24-28 gestational weeks with a 75g-OGTT between January 2018-January 2020 were retrospectively investigated. Patients with a known systemic disease, using aspirin, low-molecular-weight heparin and steroids were excluded. A total of 359 patients (81 with GDM and 278 controls) were enrolled. The assessed parameters in CBC were hemoglobin, hematocrit, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cells (including neutrophils, lymphocytes, monocytes, eosinophils, basophils), platelets, platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), nucleated red blood cell (NRBC), NRBC percentage, plateletcrit (PCT), platelet large cell ratio (P-LCR), immature granulocytes (IG) and IG percentage. Platelet mass index (PMI), neutrophil-tolymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were calculated. These parameters were compared between GDM patients and controls. Regression analysis was performed with the parameters that were significantly correlated with GDM. ROC curve analysis was done in order to find cutoff values. Results: RBC, WBC (all subtypes including immature granulocytes), platelet indices including PMI, NLR and PLR were all similar. Only RDW and NRBC were found to be significantly increased in GDM patients and came out to be independent predictors of GDM with maternal age and screening week. Conclusion: These findings suggest that women with GDM may be accompanied with increased RDW and NRBC levels which seem to be independent predictors of this disease and these parameters may be used to monitor and evaluate the development of GDM.

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Section: Discussionmentioning

confidence: 99%

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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“…In conclusion, it is evident that HG conditions have detrimental effects on different cell types, including cancer cells, and may also change their normal functions, i.e. migration potential and invasiveness[ 1 , 2 , 48 - 50 ]. Hence, understanding the mechanism of apoptosis by chronic exposure to HG, both in vitro and in vivo , will help efforts to combine preconditioning strategies, especially the subcellular preconditioning approach.…”

Section: Discussionmentioning

confidence: 99%

High glucose microenvironment and human mesenchymal stem cell behavior

Mateen,

Alaagib,

Haider

2024

World J Stem Cells

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High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mammalian target of rapamycin (mTOR)-phosphoinositide 3-kinase (PI3K)-Akt signaling, to impact physiological cellular functions, leading to low cell survival and higher cell apoptosis rates. While elucidating the underlying mechanism responsible for the apoptosis of adipose tissue-derived mesenchymal stem cells (MSCs), a recent study has shown that HG culture conditions dysregulate mTOR-PI3K-Akt signaling in addition to mitochondrial malfunctioning due to defective mitochondrial membrane potential (MtMP) that lowers ATP production. This organelle-level dysfunction energy-starves the cells and increases oxidative stress and ultrastructural abnormalities. Disruption of the mitochondrial electron transport chain produces an altered mitochondrial NAD+/NADH redox state as evidenced by a low NAD+/NADH ratio that primarily contributes to the reduced cell survival in HG. Some previous studies have also reported altered mitochondrial membrane polarity (causing hyperpolarization) and reduced mitochondrial cell mass, leading to perturbed mitochondrial homeostasis. The hostile microenvironment created by HG exposure creates structural and functional changes in the mitochondria, altering their bioenergetics and reducing their capacity to produce ATP. These are significant data, as MSCs are extensively studied for tissue regeneration and restoring their normal functioning in cell-based therapy. Therefore, MSCs from hyperglycemic donors should be cautiously used in clinical settings for cell-based therapy due to concerns of their poor survival rates and increased rates of post engraftment proliferation. As hyperglycemia alters the bioenergetics of donor MSCs, rectifying the loss of MtMP may be an excellent target for future research to restore the normal functioning of MSCs in hyperglycemic patients.

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“…The study showed that when the coefficient of variation of RDW was greater than 13.6, the likelihood of lung tissue injury increased by 9.3 times, and it was a lung volume marker for COVID-19 severity. 35 Studies have proved that increased RDW is common in human disorders, including cardiovascular disease, 36 venous thromboembolism, 37 cancer, 38 diabetes, 39 community-acquired pneumonia, chronic obstructive pulmonary disease, 37 liver, 40 and kidney failure, 41 and so on. Increased RDW reflects a severe dysregulation of erythrocyte homeostasis, including impaired erythropoiesis and abnormal erythrocyte survival.…”

Section: Discussionmentioning

confidence: 99%

Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study

Shen¹,

Chen²,

Chi³

et al. 2023

IDR

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Purpose Information about dynamic changes occurring in the parameters and morphology of erythrocytes and platelets during the coronavirus disease 2019 (COVID-19) infection and convalescence is scarce. To explore potential associations between dynamic erythrocyte and platelet parameters, morphological changes, and the course or severity of the disease is essential. Patients and Methods From January 17th, 2020, to February 20th, 2022, we followed up on 35 patients with non-severe and 11 patients with severe COVID-19 following their discharge. We collected clinical features, dynamic complete blood count (CBC), and peripheral blood smears (PBS) and analyzed parameter and morphological changes of erythrocytes and platelets depending on the course or severity of the disease. The course of the disease included four periods, namely onset (T1), discharge (T2), 1-year follow-up (T3), and 2-year follow-up (T4). Results Red blood cell (RBC) counts and hemoglobin were the lowest in T2, followed by T1, and lower in T1 and T2 than in T3 and T4. Inversely, the red blood cell distribution width (RDW) was the highest in T2, followed by T1, and higher than in T3 and T4. Compared to non-severe patients, the platelet of severe patients was lower in T1 and T2. In contrast, the mean platelet volume (MPV) and platelet distribution width (PDW) tended to be higher in severe patients. Similarly, anisocytosis was more common in peripheral blood smears at early stages and in severe patients. Finally, large platelets were more common in severe patients. Conclusion Anisocytosis of erythrocytes and large platelets are found in patients with severe COVID-19, these changes may help primary hospitals to identify patients with a high risk of severe COVID-19 at an early stage.

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Morphology and Chromic Status of Red Blood Cells Are Significantly Influenced by Gestational Diabetes

Cited by 15 publications

References 28 publications

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

High glucose microenvironment and human mesenchymal stem cell behavior

Parameters and Morphological Changes of Erythrocytes and Platelets of COVID-19 Subjects: A Longitudinal Cohort Study

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