Morphology and Cytochemistry of the Endocrine Epithelial System in the Lung

Adrenoceptor‐ and cholinoceptor‐mediated mechanisms in the regulation of 5‐hydroxytryptamine release from isolated tracheae of newborn rabbits

“…Lee et al, 1987;Balaguer & Romano, 1991;Adriaensen & Scheuermann, 1993;Bousbaa et al, 1994). So far, these neuroendocrine epithelial (NEE) cells have been characterized primarily by morphological aspects and by their content of various peptides and amines (e.g Lauweryns et al, 1972;Cutz et al, 1975;1981;Track & Cutz, 1982;Polak & Bloom, 1982;Scheuermann, 1987;Adriaensen & Scheuermann, 1993). 5-Hydroxytryptamine (5-HT) is an important amine in the NEE cells (Dey et al, 1981;Lauweryns et al, 1973; where it appears to be stored in dense core vesicles (i.e.…”

“…5-Hydroxytryptamine (5-HT) is an important amine in the NEE cells (Dey et al, 1981;Lauweryns et al, 1973; where it appears to be stored in dense core vesicles (i.e. secretory granules of the NEE cells) (Owman et al, 1973;Cutz et al, 1975;Scheuermann, 1987;Adriaensen & Scheuermann, 1993). 5-HT together with the different secretory peptides may be released from the NEE cells in response to specific, at present however, largely unknown stimuli.…”

An Immunohistochemical Study on Neurons and Paraneurons of the Pre- and Post-Natal Chicken Lung.

“…There are numerous studies on the immunohistochemical localization of peptides and amines in the neurons and paraneurons of mammalian lung, both during fetal growth and in young and adult animals (for reviews, see POLAK and BLOOM, 1986;BARNES, 1987;SCHEUERMANN, 1987). Only a few analogous studies are, however, available for other vertebrate classes (CUTZ et al, 1986;PASTOR et al, 1987;SCHEUERMANN et al, 1989;ADRIAENSEN et al, 1991).…”

Phylogenetic aspects of the neuroepithelial bodies.

“…These profiles are generally found only at or towards the base of the NEB. It has been presumed (SCHEUERMANN, 1987) that these represent efferent adrenergic junctions derive from FIF positive nerve fibres reported (LAUWERYNS and PEUS -KENS, 1972;HUNG, 1980) as present in the vicinity of NEBs.…”

“…The individual cells are irregularly columnar and in many but not all cases extend from the basement membrane to the lumen where the apical pole bears microvilli. Typically the NEBs are found in the more distal parts of the respiratory tract often at the bifurcations of the bronchioles, although they do occur in the bronchi and even in the alveoli (SCHEUERMANN, 1987). Granules located in the basal region of the cells have been identified as dense cored vesicles (DCV) which are variable in shape, size (60-200 nm diameter) and electron density (BENSCH et al, 1965).…”