Morphology Control Strategy of Bimetallic MOF Nanosheets for Upgrading the Sensitivity of Noninvasive Glucose Detection

Abstract

The precise measurement of glucose level is significant for the health management of the human body. However, the existing sensitive materials and detection methods for glucose are less satisfying for practical applications. Herein, an ultrathin reticular two-dimensional nanosheets array composed of trimesic acid (H 3 BTC)-based bimetal metal−organic frameworks (MOFs) and carbon cloth (CC), which is constructed through a morphology control strategy, is reported for glucose sensing. Meanwhile, this nonmoving sweat glucose sensor based on a NiCo-BTC/CC electrode has been successfully prepared by a screen printing method. Benefiting from the regular and ultrathin nanosheets array, the NiCo-BTC/CC electrode has an excellent sensitivity of 2701.29 μA mM −1 cm −2 , which is about 2.4 times that of its unregulated counterpart (1127.85 μA mM −1 cm −2 ) in the linear range 5−205 μM. In addition, an ultralow detection limit (0.09 μM, S/N = 3) and good selectivity of NiCo-BTC/CC were also obtained. The high sensitivity of the glucose sensor based on NiCo-BTC/CC electrode is 0.174 μA μM −1 (50−1000 μM). Remarkably, the preciously designed sensor is used to detect glucose concentration in sweat with a noninvasive mode, and the results are basically consistent with those of a commercial glucose device with an invasive mode. This research exhibits potential methodology for the morphology design of bimetallic MOFs nanosheets to achieve a high accuracy rate and noninvasive and timeless measurement of a glucose sensor.

One-step synthesis of 2D@3D hollow Prussian blue analogue as a high-performance bifunctional electrochemical sensor

“…During the oxidation process of glucose, its mechanism can be presumably illustrated according to relevant literature. 29–31 …”

Metal–organic framework-derived photoelectrochemical sensors: structural design and biosensing technology

“…[34][35][36][37] Based on the structuredetermined property, MOFs have been proven to bring about high selectivity, sensitivity, and reproducibility in constructing sensing devices. [38][39][40][41][42] The structure and composition of MOFs are closely correlated with the sensing performance parameters in terms of the limit of detection (LOD) and relative standard deviation (RSD) for stability and reproducibility.…”

A sensitive enzyme-free electrochemical sensor based on a rod-shaped bimetallic MOF anchored on graphene oxide nanosheets for determination of glucose in huangshui

“…Therefore, bimetallic NiCo-MOF has outstanding catalytic performance compared with single-metal Ni-based MOF and Co-based MOF. 34 By introducing new metal nodes into the organic framework, the catalytic performance of MOF can be adjusted and enhanced. In addition, a typical method to increase MOF materials' conductivity is to link MOF with conductive materials.…”