Morphometric Evaluation of Skin Structures by Stereologic Methods

Sauter, Lilianna S.; Weibel, Ewald R.

doi:10.1159/000252189

Cited by 14 publications

(7 citation statements)

References 10 publications

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“…This material was examined under a linear magnification of 28x . We counted the total number of spots representing the number of active se baceous follicles as well as the size of the spots by using an image analyzer MOP-Videoplan with the principles of morphometry [Weibel, 1963;Weibel et al, 1966;Sauter and Weibel, 1971]. In arbitrary units, the smallest surface of the spots was considered as one unit.…”

Section: Methodsmentioning

confidence: 99%

Follicule to Follicule Heterogeneity of Sebum Excretion

Piérard¹

1986

Dermatology

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We have evaluated the normal variations in the sebum excretion rate from follicle to follicle on the forehead by using the noninvasive techniques of the Lipometre® and Sebutape®. For a given overall amount of sebum excreted to the surface of the skin during a limited period of time, both the number of active sebaceous follicles and the amount of lipids excreted by them may vary. Significant intraindividual and interindividual differences may be found for these parameters. Such a noninvasive approach to the biology of sebaceous glands represents a new tool allowing a precise evaluation of diseases of the sebum excretion and of their treatments.

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Section: Methodsmentioning

confidence: 99%

Follicule to Follicule Heterogeneity of Sebum Excretion

Piérard¹

1986

Dermatology

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“…Androgen‐dependent hair follicles secrete soluble factors in response to testosterone such as IGF‐1 that stimulate the growth of follicular epithelial cells 47 or inhibit the growth of complete hair follicles 48 . Other groups have reported on the secretion of stem cell factor 49,50 upon stimulation with testosterone. Whether this is of pathophysiological importance in AGA is notyet known.…”

Section: Androgen‐responsive Genesmentioning

confidence: 99%

Male androgenetic alopecia

Hoffmann

2002

Clinical and Experimental Dermatology

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Androgenetic alopecia (AGA) is the most common type of hair loss in men. The relative strong concordance of the degree of baldness in fathers and sons is not consistent with a smiple Mendelian trait and a polygenic basis is considered to be most likely. So far the predisposing genes for AGA are unknown and we do not understand the molecular steps involved in androgen-dependent beard growth versus androgen-dependent hair loss, but AGA can be defined as a DHT-dependent process with continuous miniaturization of sensitive hair follicles. The type 2 5aR plays a central role by the intrafollicular conversion of T to DHT. Due to the inceasing knowledge in this field, this article shall privide an critical overwiew of recent discoveries.

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“…Most stereological investigations have been performed at the ultrastructural level, where a considerable range of cytological parameters can be quantified. Only a few stereological studies have employed histological material (Sauter and Weibel, 1971;Dunnill and Whitehead, 1972;Underwood, 1972;Risdon, 1974;Risdon and Keeling, 1974;Gerstl, Wong and Yesner, 1976); this is probably due to the limited resolution of the light microscope and the difficulties that may be involved in identifying profile boundaries in histological sections of finite thickness. Some of these studies, however, have shown potential for diagnostic use.…”

Section: Pathological Implicationsmentioning

confidence: 99%

Stereological analysis of histological parameters in experimental premalignant hamster cheek pouch epithelium

Franklin

Smith

1980

The Journal of Pathology

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Hamster cheek pouch mucosa was treated with the carcinogen DMBA in order to provide samples of epithelium in the various pathological stages of carcinogenesis. Stereological techniques were applied to histological sections of normal and carcinogen-treated epithelium in order to quantify cytological and tissue parameters that may be related to the features of epithelial atypia. The results were compared with values previously obtained for benign epithelial hyperplasia induced by a solution of oil of turpentine. Of the parameters investigated, the nuclear-cytoplasmic ratio, nuclear numerical density and volume-to-interface area ratios were best able to distinguish between benign and premalignant epithelium. The ability to ascribe actual numerical values to histological features which are usually only subjectively evaluated may be a useful diagnostic aid.

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Morphometric Evaluation of Skin Structures by Stereologic Methods

Cited by 14 publications

References 10 publications

Follicule to Follicule Heterogeneity of Sebum Excretion

Follicule to Follicule Heterogeneity of Sebum Excretion

Male androgenetic alopecia

Stereological analysis of histological parameters in experimental premalignant hamster cheek pouch epithelium

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