Mortality prediction using CHADS2/CHA2DS2-VASc/R2CHADS2 scores in systolic heart failure patients with or without atrial fibrillation

Chen, Yung Lung; Cheng, Ching Lan; Huang, Jin Long; Yang, Ning; Chang, Heng Chia; Chang, Kuan Cheng; Sung, Shih Hsien; Shyu, Kou Gi; Wang, Chun Chieh; Yin, Wei Hsian; Lin, Jiunn Lee; Chen, Shyh Ming

doi:10.1097/md.0000000000008338

Cited by 34 publications

(34 citation statements)

References 29 publications

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“…In the present study, mortality was high in both Indeed, multiple risk factors were associated with the risks of stroke and mortality in patients with AF 26 . Also, we confirm the good performance of the CHA 2 DS 2 -VASc score in predicting stroke and mortality as was demonstrated previously [27][28][29][30][31] . Stroke only accounts for 10% of the mortality seen in AF; whilst other cardiovascular diseases account for nearly 70% 32,33 .…”

Section: Safe Cohorts Separatelysupporting

confidence: 91%

One-year risks of stroke and mortality in patients with atrial fibrillation from different clinical settings: The Gulf SAFE registry and Darlington AF registry

Miyazawa

Wolff

et al. 2019

International Journal of Cardiology

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Background: AF patients from different clinical settings may have varying outcomes. We aimed to provide patient-level comparisons using two cohorts of patients with AF from different settings. Methods: The clinical characteristics, prescription of OAC, one-year risks of stroke and mortality were compared between patients with AF included into the Darlington AF registry (general practice-based cohort from the United Kingdom, n=2258) and the Gulf SAFE (Survey of atrial fibrillation events) registry (emergency room-based cohort from the Gulf countries, n=1740). Results: Patients from the Gulf SAFE registry were younger, had high prevalence of diabetes, vascular disease, heart failure. Patients from the Darlington registry had higher prevalence of hypertension, previous thromboembolism event, and higher mean stroke risk. OAC use was <60% in high stroke risk patients in both registries. On multivariate analyses, patients from Gulf SAFE were independently associated with higher risks of stroke (odds ratio, 2.18 [1.47-3.23]) and mortality (odds ratio, 1.67 [1.31-2.14]), especially in those with high CHA 2 DS 2-VASc score (≥2 in males, ≥3 in females) (Darlington vs. Gulf SAFE: 3.51% vs. 5.63 for stroke; 11.4% vs. 16.8% for mortality) Conclusions: Differences regarding AF patients profile, OAC use and outcomes exist in varying clinical settings as reflected by registries from different origins. Tailored AF management strategy are needed to fit in different clinical settings.

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Section: Safe Cohorts Separatelysupporting

confidence: 91%

One-year risks of stroke and mortality in patients with atrial fibrillation from different clinical settings: The Gulf SAFE registry and Darlington AF registry

Miyazawa

Wolff

et al. 2019

International Journal of Cardiology

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“…However, CHA 2 DS 2 -VASc score had recently become a more useful score and outperformed CHADS 2 score for prediction of stroke and systemic embolization 12 , 14 . In addition, both of CHADS 2 and CHA 2 DS 2 -VASc scores were also used to predict CV outcomes in non-AF patients 9 – 11 , 15 – 17 . Chen et al reported that CHADS 2 and CHA 2 DS 2 -VASc scores could be used to predict 1-year all-cause mortality in patients with systolic heart failure 15 .…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, in recent years, CHA 2 DS 2 -VASc score has become a more useful score than CHADS 2 score for prediction of stroke and systemic embolization in AF patients 12 – 14 . This new scoring system was also used to predict future CV outcome including mortality in non-AF patients 15 – 17 . However, there was no literature discussing about the usefulness of CHADS 2 and CHA2DS2-VASc scores for CV and all-cause mortality prediction in the patients with CKD.…”

Section: Introductionmentioning

confidence: 99%

Using CHADS2 and CHA2DS2-VASc scores for mortality prediction in patients with chronic kidney disease

Hsu

Lee

Chen

et al. 2020

Sci Rep

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Chronic kidney disease (CKD) is a public health issue and is associated with high morbidity and mortality. How to identify the high-risk CKD patients is very important to improve the long-term outcome. CHADS2 and CHA2DS2-VASc scores are clinically useful scores to evaluate the risk of stroke in patients with atrial fibrillation. However, there was no literature discussing about the usefulness of CHADS2 and CHA2DS2-VASc scores for cardiovascular (CV) and all-cause mortality prediction in CKD patients. This longitudinal study enrolled 437 patients with CKD. CHADS2 and CHA2DS2-VASc scores were calculated for each patient. CV and all-cause mortality data were collected for long-term outcome prediction. The median follow-up to mortality was 91 (25th–75th percentile: 59–101) months. There were 66 CV mortality and 165 all-cause mortality. In addition to age and heart rate, CHADS2 and CHA2DS2-VASc scores (both P value < 0.001) were significant predictors of CV and all-cause mortality in the multivariate analysis. Besides, in direct comparison of multivariate model, basic model + CHA2DS2-VASc score had a better additive predictive value for all-cause mortality than basic model + CHADS2 score (P = 0.031). In conclusion, our study showed both of CHADS2 and CHA2DS2-VASc scores were significant predictors for long-term CV and all-cause mortality in CKD patients and CHA2DS2-VASc score had a better predictive value than CHADS2 score for all-cause mortality in direct comparison of multivariate model. Therefore, using CHADS2 and CHA2DS2-VASc scores to screen CKD patients may be helpful in identifying the high-risk group with increased mortality.

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“…Кроме того, этот инструмент оказался приемлемым предиктором годичной смертности у больных с ХСН со сниженной фракцией изгнания ЛЖ и ФП. Интересно, что наибольшая предсказательная точность шкалы оказалась у пациентов с ХСН и синусовым ритмом [26].…”

Section: обзоры §unclassified

Impaired kidney function in patients with atrial fibrillation: practical aspects

Мелехов

Дадашова

Никитин

2018

CARDIO

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Резюме В статье рассматриваются практические аспекты ведения пациентов с часто встречаемой комбинацией фибрилляции предсердий (ФП) и хронической болезни почек (ХБП). На примере собственных данных частота встречаемости ХБП различных стадий у больных с ФП сопоставлена с зарубежными наблюдениями; демонстрируется взаимосвязь выраженности ЭхоКГ изменений и ХБП; приводится сопоставление антитромботической профилактики у этих пациентов в условиях реальной практики с существующими рекомендациями.

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Mortality prediction using CHADS2/CHA2DS2-VASc/R2CHADS2 scores in systolic heart failure patients with or without atrial fibrillation

Abstract: Supplemental Digital Content is available in the text

Cited by 34 publications

References 29 publications

One-year risks of stroke and mortality in patients with atrial fibrillation from different clinical settings: The Gulf SAFE registry and Darlington AF registry

One-year risks of stroke and mortality in patients with atrial fibrillation from different clinical settings: The Gulf SAFE registry and Darlington AF registry

Using CHADS2 and CHA2DS2-VASc scores for mortality prediction in patients with chronic kidney disease

Impaired kidney function in patients with atrial fibrillation: practical aspects

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