Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy

Sontag, Stephen J.; O’Çonnell, Susan; Khandelwal, Sharad; Miller, Todd Q.; Nemchausky, Bernard A.; Schnell, Thomas; Serlovsky, Rose

doi:10.1016/0016-5085(90)90945-w

Cited by 365 publications

(178 citation statements)

References 33 publications

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“…77,78 Reports of GERD-related symptoms in adults with asthma range from 65% to 77%. 61,[79][80][81] In a large case-controlled study, El-Serag et al 61 reported that EE and esophageal stricture were associated with chronic bronchitis, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchiectasis, and pneumonia, with odds ratios ranging from 1.15 to 1.50. In a recent 5-year follow-up of the original ProGERD study, the prevalence of asthma in GERD patients had increased from 4.5% at entry to 7.8% at the end of follow-up.…”

Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

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Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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“…The prevalence of abnormal esophageal pH is, however, highly variable, ranging from 12-85% of asthmatic patients, while GERD symptoms are reported in 50-80% of asthmatics [80,81]. Furthermore, a significant percentage of these last have silent GERD and do not experience classic symptoms such as heartburn [82,83].…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Asthma-related comorbidities

Boulet¹,

Boulay²

2011

Expert Review of Respiratory Medicine

226

147

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“…Additionally, a high prevalence of GER in patients with asthma has been widely reported (3)(4)(5). Ruling in or out a diagnosis of GER is important in the clinical management of oral and respiratory symptoms.…”

Section: Introductionmentioning

confidence: 99%

A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma

et al. 2010

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: Salivary pH is associated with esophageal acid reflux and neutralization of esophageal acid. In this study, we assessed the association between nocturnal decline of salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients with mild asthma (7 men and 2 women ; mean age 33.3 years ; mean % %predicted FEV1.0 89.4% %) and 10 healthy volunteers (6 men and 4 women ; mean age 31.2 years) using a pH indicator tape. The buffering capacity of saliva was defined as the median effective dose (ED50) for acidification of saliva with 0.01 N HCl, and airway responsiveness was defined as the dose of methacholine producing a 35% % fall in Grs (PD35-Grs). There was a significant correlation between the values obtained from the pH indicator tape and those obtained from the electrometric pH meter. Using the indicator tape for sequential monitoring, we observed a nocturnal fall (!pH) in salivary pH in all subjects. A significant correlation was found between airway hyperresponsiveness (PD35-Grs) and either !pH or ED50 in mildly asthmatic patients. Vagal reflux dysfunction might contribute to nocturnal salivary pH as well as to airway hyperresponsiveness in mild asthmatics. J. Med. Invest.

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Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy

Cited by 365 publications

References 33 publications

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Asthma-related comorbidities

A nocturnal decline of salivary pH associated with airway hyperresponsiveness in asthma

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